ENGLISH|院长信箱|书记信箱
师资队伍
杨国华

1、职称职务:博士、副教授、硕士生导师,系副主任杨国华

2、学科专业:医学遗传学

3、研究方向:单基因病的基因诊断、克隆和功能研究                                

4、联系电话:68759702

5、Email:ghyang@whu.edu.cn    

6、学习经历:

    1992.9-1995.7  湖北工程学院生物系专科学习;

    2001.9-2006.12  武汉大学生命科学学院遗传学专业硕博连读。

7、主要工作经历与任职

    1995.9-1999.7   武钢九中生物教师;

    1999.10-2001.3  武汉科诺生物农药公司销售经理;

    2007.1-2010.8   武汉大学基础医学院讲师;

    2010.9-2011.10  湖北省随州市卫生局副局长;

    2011.10 –至今  武汉大学基础医学院副教授,硕士生导师。

8、目前主要科学研究领域和兴趣

    单基因病相关基因的克隆和功能研究,疾病基因诊断新方法的研究。

9、教学情况:

    1)《细胞生物学》(五、七、八年制);

    2)《医学遗传学》(五、七、八年制及外语教学班);

    3)《基因组学》(八年制);

    4)《细胞、分子与基因》(本科芝加哥实验班);

    5)《医学基因工程》 硕士研究生;

    6)《细胞遗传学实验技术》(硕士研究生);

    7)《Genetics》 留学生班。

10、近5年代表性论文

    1) Li C, Wang L, Zhang J, Huang M, Wong F, Liu X, Liu F, Cui X, Yang G, Chen J, Liu Y, Wang J, Liao S, Gao M, Hu X, Shu X, Wang Q, Yin Z, Tang Z, Liu M. CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochim Biophys Acta. 2014; 1842(7):1121-9.

    2) Changyong Li, Guohua Yang, Jie Ruan, Sphingosine kinase 1/sphingosine-1- phosphate receptor type 1signalling axis is induced by transforming growth factor-β1 and stimulates cell migration in RAW264.7 macrophages, Biochemical and Biophysical Research Communications. 2012; 426(3): 415-420.

    3) Risheng Liang, Xiaolei Zhuo,Guohua Yang, Daji Luo, Shan Zhong, Jixing Zou. Molecular phylogenetic relationships of family Haemulidae and the related species based on mitochondrial and nuclear genes. Mitochondrial DNA. 2012, 23(4):264-77.

    4) Juan Tian, Guohua Yang, Songshan Wang, Yuanzhen Zhang, Guibo Song, Fang Zheng. Molecular diagnosis of two families with classic congenital adrenal hyperplasia. Gene. 2011, 482(1-2): 8-14.

    5) Guohua Yang, Shan Zhong, Xianrong Zhang, Biwen Peng, Jun Li, Tie Ke, Hua Xu. Molecular Genetic Analysis of Autosomal Dominant Late-Onset Cataract in a Chinese Family. J Huazhong Univ Sci Technol. 2010, 30(6):792-6.

    6) Yukan Huang, Jing Zhang, Chang Li, GuohuaYang, Mugen Liu, Qing. Wang, Zhaohui Tang. Identification of a novel homozygous nonsense mutation in EYS in a Chinese family with autosomal recessive retinitis pigmentosa. BMC Med Genet. 2010, 11: 121-6.

    7) Kun Wang, Ya Gao, Xiaojue Peng, Guohua Yang, Feng Gao, Shaoqing Li, Yingguo Zhu. Using FAM labeled DNA oligos to do RNA electrophoretic mobility shift assay. Molecular Biology Reports. Mol Biol Rep. 2010, 37(6):2871-5.

    8) Jie Lin, Xu Lin, Guohua Yang, Yong Wang, Biwen Peng, Jianyin Lin. Toxoplasma gondii: Expression of GRA1 gene in endoplasmic reticulum promotes both growth and adherence and modulates intracellular calcium release in macrophages. Experimental Parasitology. Experimental Parasitology. 2010, 125: 165-8.

    9) Shan Zhong*, Guohua Yang*, Cong Xia, Duanlian Zhang, Shengguo Shan. Expression of matrix metalloproteinase and its tissue inhibitor in haemangioma. J Huazhong Univ Sci Technol. 2009, 29(5):614-6.

    10) Guo-Hua Yang, Yong-Zhong Xing, Shao-Qing Li, Jing-Zhen Ding, Bing Yue, Kai Deng, Yang-Sheng Li, Ying-Guo Zhu. Molecular dissection of developmental behavior of tiller number and plant height and their relationship in rice (Oryza sativa L.). Hereditas. 2006, 143: 236-10.

    11) Guohua Yang, Sansi Tu, Shaoqing Li, Lingling Feng, Jin Kong, Hui Li, Kai Deng, Yangsheng Li. Analysis of QTLs Underlying the Traits Relative to Chlorophyll Content of the Flag Leaf in Rice. Frontiers of biology. 2008, 3 (4):443-6.

    12) Shao-Qing Li, Guo-Hua Yang, shao-bo Li, Yang-Sheng Li, Zu-Yu Chen, Ying-Guo Zhu. Distribution of fertility-restorer genes for wild-abortive and Honglian CMS lines of rice in the AA genome species of genus Oryza. Annals of Botany. 2005, 96:461-6.