ENGLISH|院长信箱|书记信箱
师资队伍
徐丹

1、职称职务: 副教授徐丹NH1A2459_副本

2、学科专业: 药理学

3、研究方向: 药物发育毒理

4、实验室位置: 2号楼4楼

5、联系电话: 027-68758959

6、Email: xuyidan70188@163.com

7、学习经历:

      2007/09 -2010/06,武汉大学,基础医学院药理学系,博士
      2005/09-2007/06,武汉大学,基础医学院药理学系,硕士
      2000/09-2005/06,武汉大学,医学院临床医学专业,学士

8、主要工作经历与任职

      2013/01-至今,武汉大学,基础医学院药理学系,副教授
      2011/01 -2012/12,武汉大学,基础医学院药理学系,讲师
      2010/07 -2012/06,武汉大学,生命科学学院发育生物学,博士后
      2010/07-2010/12,武汉大学,基础医学院药理学系,助教

9、目前主要科学研究领域和兴趣

      主要从事外源物发育毒理和胎源性疾病发病机制研究。在前期研究中,系统证实了孕期外源物(咖啡因、尼古丁)暴露所致宫内发育迟缓(IUGR)子代成年下丘脑-垂体-肾上腺(HPA)轴相关疾病(如脂肪肝、抑郁症)易感的胎儿起源现象,创新性提出咖啡因、尼古丁所致胎HPA轴轴神经内分泌代谢编程改变是引起IUGR仔鼠成年HPA轴相关疾病易感的胎儿起源机制。

10、教学情况:

      承担研究生、本科生、留学生(全英)的教学; 积极开展教学研究;发表教学论文1篇;参编教材1部。

11、近5年代表性论文

      (1)Xu D, Wu Y, Liu F, Liu YS, Shen L, Lei YY, Liu J, Ping J, Qin J, Zhang C, Chen LB, Magdalou J, Wang H. A hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion. Toxicol Appl Pharmacol.2012; 64(3): 395-403

      (2)Xu D, Zhang BJ, Liang G, Ping J, Kou H, Li XJ, Xiong J, Chen LB, Magdalou J, Wang H*. Caffeine-induced activated glucocorticoid metabolism in hippocampus causes hypothalamic-pituitary-adrenal axis inhibition in fetal rats. PLoS ONE. 2012; 7(9): e44497.

      (3)Liu YS, Xu D (co-first author), Feng JH, Kou H, Liang G, Yu H, He XH, Zhang BF, Chen LB, Magdalou J, Wang H*. Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways. Toxicol Appl Pharmacol. 2012; 15; 262(2): 205-16.

      (4)Xu D, Liang G, Yan YE, He WW, Liu YS, Chen LB, Magdalou J, Wang H*. Nicotine-induced over-exposure to maternal glucocorticoid and activated glucocorticoid metabolism causes hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic alterations in fetal rats. Toxicol Lett. 2012; 209(3): 282-90.

      (5)Xu D, Chen M, Pan XL, Xia LP, Wang H*. Dexamethasone induces fetal developmental toxicity through affecting the placental glucocorticoid barrier and depressing fetal adrenal function. Environ Toxicol Pharmacol. 2011; 32(3): 356-63. 被国际生物和医学论文评价系统“Faculty of 1000”选为“推荐”论文(http://f1000.com/14264021)

      (6)Xu D, Chen M, Guo Y, Liang G, Zhang B, Tan J, Magdalou J, Wang H. Synergistic antifibrotic effect of verapamil and interferon-gamma in rats: partially based on enhanced verapamil oral bioavailability. Eur J Gastroenterol Hepatol. 2010; 22(4): 466-73.

      (7)Xu D, Zhang BJ, Ping J, Liang G, Liu F, Kou H, Wang H*. Intrauterine Origin of Caffeine-Induced High Susceptibility to Adult Metabolic Syndrome: Alleviated Glucocorticoid Inactivation Alters the Neuroendocrine Metabolic Programming of Fetal Rats. 17th North American Regional ISSX Meeting. Drug Metabol Rev. 2011; 43: S2 146. Abstract.

      (8)Xu D, Zhang BJ, Ping J, Wang H*. Synergistic Antifibrotic Effect of Verapamil and Interferon-γ in Rats: A Mechanism Based Partially on Enhanced Verapamil Oral Bioavailability. 2th Asian Pacific Regional ISSX Meeting. Drug Metabol Rev. 2008; 40: 176-7. Abscract.