4、联系电话: 027-68759735

5、Email: hl-chen@whu.edu.cn

6、学习经历 Education

1994年9月-1999年7月 原咸宁医学院 临床医学系 本科

1999年9月-2002年7月 武汉大学基础医学院 病理学与病理生理学 硕士

2005年9月-2010年7月  武汉大学人民医院  内科学 博士

7、主要工作经历与任职 Professional Background

2013,9-至今 武汉大学基础医学院病理学与病理生理学系 副教授

2012,5-2013,8 美国Rush University Medical Center生物化学系  博士后

2010-2012,4 武汉大学基础医学院病理学与病理生理学系 副教授

2005-2010 武汉大学基础医学院病理学与病理生理学系 讲师

2002-2005  武汉大学基础医学院病理学与病理生理学系 助教

8、目前主要科学研究领域和兴趣 Research Interest

      肿瘤微环境和肿瘤能量代谢机制与恶性肿瘤侵袭转移的关系。纳米材料在肿瘤生物医学成像中的应用。The relationship between tumor microenvironment, tumor energy metabolism mechanism and cancer invasion and metastasis. Nano materials application in the biomedical imaging of cancer.

9、教学情况 Teaching


10、近5年代表性论文 Publications ( The first and corresponding author)

1.  Zhao X, He Y, Gao J, Zhao C, Zhang L, Tian J, Chen H. High expression of Bcl-2 protein predicts favorable outcome in patients with non-small cell lung cancer: evidence from a Systematic Review and Meta-analysis. Asian Pac J Cancer Prev. 2014,15(20):8861-9.

2. Zhao C, Lu F, Chen H, Zhao X, Sun J, Chen H. Dysregulation of JAM-A plays an important role in human tumor progression. Int J Clin Exp Pathol, 2014, 7(10):7242-8.

3. Zhao H, Zhang X, Chen X, Li Y, Ke Z, Tang T, Chai H, Guo AM, Chen H*, Yang J*. Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. Toxicol Appl Pharmacol. 2014, 279(3):311-21.

4. Chen H, Wu S, Lu R, Zhang Y, Zheng Y, Sun J. Pulmonary permeability assessed by fluoresce-labeled dextran instilled intranasally into mice with LPS-induced acute lung injury. PLoS One, 2014, 9(7): e101925.

5. He Y, Zhao X, Subahan NR, Fan L, Gao J, Chen H. The Prognostic Value of Autophagic Related Markers Beclin-1 and Light Chain 3 in Cancers: A Systematic Review and Meta-analysis. Tumor Biology, 2014, 35(8):7317-26.

6. Hu YC, Zhang Q, Huang YH, Liu YF, Chen H. Comparison of Two Methods to Extract DNA from Formalin-Fixed, Paraffin -Embedded Tissues and Their Impact on EGFR Mutations Detection in Non-small Cell Lung Carcinoma. Asian Pac J Cancer Prev. 2014; 15 (6), 2733-2737.

7. Wang HY, Yang GF, Huang YH, Huang QW, Gao J, Zhao XD, Huang L, Chen H. Reduced expression of autophagy markers correlates with high-risk human papillomavirus infection in human cervical squamous cell carcinoma. Oncol Lett, 2014, 8(4): 1492-1498.

8. Zhao X, He Y, Gao J, Fan L, Li Z, Yang G, Chen H. Caveolin-1 expression level in cancer associated fibroblasts predicts outcome in gastric cancer. PLoS One, 2013, 8(2):e59102  

9. Zhao X, He Y, Chen H. Autophagic tumor stroma: Mechanisms and roles in tumor growth and progression. Int J Cancer. 2013, 132(1):1-8.

10. He Y, Zhao X, Gao J, Fan L, Yang G, Cho WC, Chen H. Quantum dots-based immunofluorescent imaging of stromal fibroblasts caveolin-1 and light chain 3B expression and identification of their clinical significance in human gastric cancer. Int J Mol Sci, 2012; 13(11):13764-80.

11.Sun J, Gao J, Hu JB, Fan LF, Zhu XB, Subahan Roz, Chen HL. Expression of Cav-1 in tumour cells, rather than in stromal tissue, may promote cervical squamous cell carcinomaproliferation, and correlates with high-risk HPV infection. Oncol Rep, 2012, 27(6):1733-40.

12.Peng J*, Chen HL*, Zhu XB, Yang GF, Zhang ZL, Tian ZQ, Pang DW. Detection of Epstein-Barr virus infection in gastric carcinomas using quantum dot-based fluorescence in-situ hybridization. J Nanosci Nanotechno, 2011, 11(11):9725-30.

13. Li ZH, Peng J, Chen HL. Bioconjugated quantum dots as fluorescent probes for biomedical imaging. J Nanosci Nanotechno, 2011, 11(9): 7521-36.

14. Chen HL, Fan LF, Gao J, Ouyang JP, Zhang YX. Differential expression and function of caveolin-1 gene in non-small cell lung carcinoma. Oncol Rep, 2011, 25(2):359-366

15.Chen HL, Peng J, Zhu XB, Gao J, Xue JL, Wang MW, Xia HS. Detection of EBV in nasopharyngeal carcinoma by quantum dot fluorescent in situ hybridization. Exp Mol Pathol. 2010, 89(3):367-71.

16. Xue J, Chen H, Diao L, Chen X, Xia D. Expression of caveolin-1 in tongue squamous cell carcinoma by quantum dots. Eur J Hist, 2010,54(2):99-103.