ENGLISH|院长信箱|书记信箱
师资队伍
汪晖

1、职称职务:二级教授,博士生导师个人照 (2)!!

2、基本情况:药理学系主任,兼国家中医药管理局武汉大学中药药理三级实验室主任、武汉大学食品与药品评价研锚点究中心主任

3、研究方向:药物靶标与新药研发、外源物发育毒理

4、获奖情况

    1.教学成果“基础医学本科探索性实验教学模式的构建与实践”,2009年获湖北省教学成果二等奖,为第一完成人。

    2.科研成果“新型肝脏损伤早期标志物α-GST的确证及应用”,2011年通过湖北省科技厅主持的成果鉴定, 达国际先进水平;2012年获湖北省科技进步三等奖,为第一完成人。

5、社会兼职情况

    1.国家自然科学基金第十二、十三届药物药理学学科评审组成员;

    2.国家食品药品监督管理局化妆品审评专家;

    3.国家食品药品监督管理局药品审评专家;

    4.武汉药理学会理事长。

6、主持科研项目

    1.国家自然科学基金项目重大国际合作“外源物孕期暴露所致子代骨关节炎易感及宫内内分泌代谢编程机制(批准号:81220108026)”,2013-2017

    2.国家自然科学基金重点项目“胎海马GR介导外源物所致HPA轴发育异常的表观遗传机制(批准号:30830112)”, 2009-2012

    3.教育部科学研究重大项目“代谢综合征的宫内起源机制及早期诊治技术研究(批准号:V200801)”,2012-2014

    4.国家自然科学基金“高GC活化代谢介导外源物所致胎肝代谢编程改变的信号转导机制”,2011-2013

    5.国家自然科学基金“胎肾上腺StAR/CYP11A1介导外源物所致宫内发育迟缓的分子机制(批准号:30672566)”,2007-2009

    6.国家自然科学基金“肝星状细胞异物代谢特征及其在星状细胞激活中的作用(批准号:0371666)”, 2004-2006

    7.湖北省自然科学基金创新群体“代谢组学技术确证宫内发育迟缓早期筛查诊断的生物标志物(批准号:2009CDA079)”,2009-2010

7、主持教学项目

    教育部国家级教学团队“医学机能实验学”,2010-2012

8、主要论文论著

    1.Xu D, Wu Y, Liu F, Liu YS, Shen L, Lei YY, Liu J, Ping J, Qin J, Zhang C, Chen LB, Magdalou J, Wang H*. A hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion. Toxicol Appl Pharmacol, 2012;264(3):395-403.

    2.Liu YS, Xu D, Feng JH, Kou H, Liang G, Yu H, He XH, Zhang BF, Chen LB, Magdaloue J, Wang H*. Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways. Toxicol Appl Pharmacol. 2012;262:205-16.

    3.Xiong J, Guo Y, Li LY, Hu H, Qu XL, Sun XZ, Liu SH, Wang H*. A herbal composition of Semen Hoveniae, Radix Puerariae and Fructus Schisandrae shows potent protective effects on acute alcoholic intoxication in rodent models. Evidence-Based Complementary and Alternative Medicine. 2012;2012:638197.

    4.Qin J, Shang L, Ping AS, Li J, Li XJ, Yu H, Magdalou J, Chen LB, Wang H*. TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1beta-induced rat osteoarthritis chondrocytes in vitro. Arthritis Res Ther, 2012;14(6): R242.

    5.Xu D, Zhang BJ, Liang G, Ping J, Kou H, Li XJ, Xiong J, Chen LB, Magdalou J, Wang H*. Caffeine-induced activated glucocorticoid metabolism in hippocampus causes hypothalamic-pituitary-adrenal axis inhibition in fetal rats. PloS ONE. 2012;7(9):e44497.

    6.Tan Y, Liu J, Deng Y, Cao H, Xu D, Cu FL, Lei YY, Magdalou J, Wu M, Chen L, Wang H*. Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation. Toxicol lett. 2012;214(3):279-87.

    7.Liu L, Liu F, Kou H, Zhang BJ, Xu D, Chen B, Chen LB, Magdalou J, Wang H*. Prenatal nicotine exposure induced a hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in IUGR offspring rats. Toxicol Lett. 2012;209:307-13.

    8.Xu D, Liang G, Yan YE, He WW, Liu YS, Chen LB, Magdalou J, Wang H*. Nicotine-induced over-exposure to maternal glucocorticoid and activated glucocorticoid metabolism causes hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic alterations in fetal rats. Toxicol lett. 2012;209:282-90.

    9.Ping J*, Lei Y, Liu L, Wang TT, Feng YH, Wang H*. Inheritable stimulatory effects of caffeine on steroidogenic acute regulatory protein expression and cortisol production in human adrenocortical cells. Chemico-Biological Interactions. 2012;195:68-75.

    10.Huang J, Zhou S, Ping J, Pan XL, Liang G, Xu D, Kou H, Bao C, Wang H*. Role of p53-dependent placental apoptosis in the reproductive and developmental toxicities of caffeine in rodents. Clin Exp Pharmacol Physiol 2012;39:357-63.

    11.Wang TT, Chen M, Liu L, Cheng HY, Yan YE, Feng YH, Wang H*. Nicotine induced CpG methylation of Pax6 binding motif in StAR promoter reduces the gene expression and cortisol production. Toxicol Appl Pharmacol. 2011;257:328-37.

    12.Li Y, Yan YY, Wang H*. Enhancement of placental antioxidative function and P-gp expression by sodium ferulate mediated its protective effect on rat IUGR induced by prenatal tobacco/alcohol exposure. Environ Toxicol Pharmacol. 2011;32:465-71.

    13.Xu D, Chen M, Pan XL, Xia LP, Wang H*. Dexamethasone induces fetal developmental toxicity through affecting the placental glucocorticoid barrier and depressing fetal adrenal function. Environ Toxicol Pharmacol. 2011;32:356-63.

    14.Liang G, Chen M, Pan XL, Zheng J, Wang H*. Ethanol-induced inhibition of fetal hypothalamic-pituitary-adrenal axis due to prenatal overexposure to maternal glucocorticoid in mice. Exp Toxic Pathol. 2011;63:607-11.

    15.Ping J, Li JT, Liao ZX, Shang L, Ao Y, Wang H*. Indole-3-carbinol inhibits hepatic stellate cells proliferation by blocking NADPH oxidase/reactive oxygen species/p38 MAPK pathway. Euro J Pharmacol 2011;650(2-3):656-62.

    16.Xu D, Chen M, Guo Y, Liang G, Zhang BJ, Tan JQ, Magdalou J, Wang H*. Synergistic anti-fibrotic effect of verapamil and interferon in rats: partially based on enhanced verapamil oral bioavailability. Eur J Gastroenterol Hepatol. 2010; 22(4): 466-73.

    17.Wang H*, Xu D, Chen M, Peng RX, Yue J. Testosterone-metabolizing capacity and characteristics of adrenal microsomes in human fetus in vitro. J Pediatr Endocrinol Metab. 2010; 23:143-51.

9、发明专利

    1.授权国家发明专利“一种检测HMG-CoA还原酶活性的改良分光光度法及应用”,专利号:ZL201110073398.8. 发明人:汪晖,郭喻,平洁,梁赅,王婷婷

    2.授权国家发明专利“一种预防和治疗骨髓炎的药物缓释制剂”,专利号:ZL201110048409.7. 发明人:汪晖,陈廖斌,曹洪,修涵,刘岩松

    3.授权国家发明专利“一种从当归中提取多糖的方法及应用”,专利号:ZL200810046965.9. 发明人:汪晖,陈廖斌,商亮,谭扬,李小军

    4.授权国家发明专利“一种从甘草中提取多糖的方法及应用”,申请号:ZL 200910061357.X. 发明人:汪晖,陈廖斌,李小军,汪巍,何文博,张逸杰,范雯

    5.授权国家发明专利“一种治疗骨髓炎的药物及制备方法”,专利号:ZL200510018246.2. 发明人:陈廖斌,汪晖,王钧,傅杰

10、招生情况

    博士生:2002年开始招收博士生,包括:廖长秀、黄敏、翁深宏、王芳、鄢友娥、陈曼、吴勇、夏利平、郭喻、平洁、商亮、张转、梁赅、王婷婷、徐丹、李小军,张郦、熊婕、刘岩松、刘莲、寇皓、沈朗、白兢、李景、卢娟、黄鹤归、何正、吕丰、裴林国、祝春燕

    硕士生:1996年开始招收硕士生,主要有:廖长秀、张春、李琰、胡 晓玲、鄢友娥、陈曼、郭喻、余薇、平洁、武晓茜、王婷、梁赅、张丹、肖凤琴、卢娟、潘晓靓、徐丹、鲁小杰、李婧婷、孟巍、高爱梅、王智、刘岩松、何雯雯、 李璐奕、张本坚、李瑞雯、刘芳、刘莲、雷有颖、刘瑾、寇浩、沈朗、李景、张崇、丛萌、王健飞、修涵、施偲、邓梓辛、何正、钟卫华、何靓、胡霜霜、程思源、 祝春燕、武依梦、郭自景、胡淑伟、肖笛、周瑾

    本科生:2000年开始招收本科生科研团队,至今已招收50余名。

11、联系方式

    地址:武汉大学基础医学院药理学系(430071)

    邮箱:wanghui19@whu.edu.cn