ENGLISH|院长信箱|书记信箱
师资队伍
郭德银

1、职称职务:教授、博导11

2、学科专业:微生物学/病毒学、病原生物学、分子生物学

3、研究方向:冠状病毒感染致病机制与免疫调控机理,病毒基因治疗与抗病毒药物筛选

4、联系方式: E-mail: dguo@whu.edu.cn

5、教育与工作经历

2011-2016 武汉大学基础医学院教授、院长

2002-迄今 武汉大学生命科学学院教授、副院长(2004-2011),现代病毒学研究中心主任

1996-2002 芬兰赫尔辛基大学生物技术研究所 博士后,生物科学系docent(2001)

1991-1995 德国布伦瑞克理工大学生物系博士生,联邦生物化学与植物病毒研究生研究助理

1990-1991 同济大学留德预备部 德语学习

1985-1988 中国科学院微生物研究所与中国农业科学院研究生院硕士研究生

6、学术兼职

中国微生物学会病毒专业委员会委员(2004-)

国家高等级病原微生物生物安全审查委员会委员 (2009-)

国家认可委实验室生物安全专业委员会委员(2012-)

病毒学国家重点实验室副主任(2005-)

中国细胞生物学会免疫细胞分会理事

湖北省微生物学会医学微生物专业委员会主任

蛋白质科学国家重大科学研究计划项目首席科学家(2010-)

Virologica Sinica等学术期刊编委,Nature Immunology、Nature Microbiology等学术期刊审稿人

7、奖励与荣誉

国家杰出青年基金获得者(2009)

国家“973”计划首席科学家(2009)

国家创新人才推进计划重点领域创新团队负责人(2016)

湖北省首批医学领军人才(第一层次)(2013)

中国微生物学会病毒专业委员会梅里埃奖(2010)

武汉大学十大杰出青年(教师)(2004)

武汉大学十大师德标兵(2010)

武汉大学朱裕壁医学奖(2011)

湖北省劳动模范(2004)

享受国务院政府特殊津贴专家

8、研究资助

获得国家科技部973项目、国家杰青项目、国家自然科学基金重点项目、国家自然科学基金委创新研究群体项目、国家重大传染病专项课题等资助

9、近期代表性论文:(总共发表SCI论文81篇)

1.Dan Liu, Lei Cui, Yuan Wang, Guifang Yang, Ruidong Hao, Jing He, Chengpeng Fan, Mengmeng Qu, Zhepeng Liu, Min Wang, Lang Chen and Deyin Guo (2016) HBV e antigen and its precursors promote the progress of hepatocellular carcinoma by interacting with NUMB and decreasing p53 stability and activity. Hepatology (Accepted)

2.Shun Li, Mingzhu Zhu, Ruangang Pan, Ting Fang, Yuan-Yuan Cao, Shuliang Chen, Xiaolu Zhao, Cao-Qi Lei, Lin Guo, Yu Chen, Chunmei Li, Eija Jokitalo, Yuxin Yin, Hong-Bing Shu, Deyin Guo (2016) The tumor suppressor PTEN plays a critical role in antiviral innate immunity. Nature Immunology 17, 241-249. (Advance Online Publication on Dec. 21, 2015; With expert comment in the News & Views section of the same issue).

3.Yu Chen, Hui Cai, Ji’an Pan, Nian Xiang, Po Tien, Tero Ahola, Deyin Guo (2009) Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America 106, 3484-9.

4.Yu Chen, Ceyang Su, Min Ke, Xu Jin, Lirong Xu, Zhou Zhang, Andong Wu, Ying Sun, Zhouning Yang, Po Tien, Tero Ahola, Yi Liang, Xinqi Liu, Deyin Guo (2011) Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex. PLoS Pathogens 7(10): e1002294. doi:10.1371/journal.ppat.1002294.

5.Yi Wang, Ying Sun, Andong Wu, Shan Xu, Ruangang Pan, Cong Zeng, Xu Jin, Xingyi Ge, Zhengli Shi, Tero Ahola, Yu Chen, Deyin Guo (2015) Coronavirus nsp10/nsp16 methyltransferase can be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis. Journal of Virology 89, 8416-27.

6.Lei Cui, Haiying Wang, Yanxi Ji, Jie Yang, Shan Xu, Xingyu Huang, Zidao Wang, Lei Qin, Po Tien, Xi Zhou, Deyin Guo*, Yu Chen* (2015) The Nucleocapsid protein of coronaviruses acts as a viral suppressor of RNA silencing in mammalian cells. Journal of Virology 89, 9029-43.

7.Yu Chen, Jiali Tao, Ying Sun, Andong Wu, Ceyang Su, Guozhen Gao, Hui Cai, Su Qiu, Yingliang Wu, Tero Ahola, Deyin Guo (2013) Structure-function analysis of SARS coronavirus RNA cap guanine-N7 methyltransferase. Journal of Virology 87, 6296-305.

8.Panpan Hou, Shuliang Chen, Shilei Wang, Xiao Yu, Yu Chen, Meng Jiang, Ke Zhuang, Wenzhe Ho, Wei Hou, Jian Huang and Deyin Guo (2015). Genome editing of CXCR4 by CRISPR/cas9 confers cells resistance to HIV-1 infection. Scientific Reports 2015 Oct 20;5:15577. doi: 10.1038/srep15577.

9.Ying Sun, Zidao Wang, Jiali Tao, Yi Wang, Andong Wu, Ziwen Yang, Kaimei Wang, Liqiao Shi, Yu Chen, Deyin Guo (2014) Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase. Antiviral Research 104, 156-64.

10.Mingzhu Zhu, Ting Fang, Shun Li, Kun Meng, Deyin Guo (2015) Bipartite nuclear localization signal controls nuclear import and DNA binding activity of interferon regulatory factor 3. Journal of Immunology 195, 289-97.

11.Ruidong Hao, Jing He, Xing Liu, Guozhen Gao, Dan Liu, Lei Cui, Guojun Yu, Wenhui Yu, Yu Chen, Deyin Guo (2015)  Inhibition of hepatitis B virus gene expression and replication by hepatocyte nuclear factor 6. Journal of Virology 89, 4345-55.

12.Guozhen Gao, Xiaoyun Wu, Jieqiong Zhou, Mingfeng He, Johnny J. He and Deyin Guo (2013) Inhibition of HIV-1 transcription and replication by a newly identified cyclin T1 splice variant. Journal of Biological Chemistry 288, 14297-14309.

13.Miao Jiang, Pamela Österlund, Peter Sarin, Minna Poranen, Dennis Bamford, Deyin Guo* and Ilkka Julkunen* (2011) Innate immune responses in human monocyte-derived dendritic cells are highly dependent on the size and the 5'-phosphorylation of RNA molecules. Journal of Immunology 187, 1713-21.