ENGLISH|院长信箱|书记信箱
师资队伍
何小华

1、职称职务: 教授、博导、基础医学院副院长何小华登记照

2、学科专业:病理生理学 

3、研究方向: 神经病理生理 

4、联系电话:027-68759991

5、Email: hexiaohua@whu.edu.cn

6、学习经历 

      1997.09-2000.07  华中科技大学同济医学院,获神经病学博士学位

      1994.09-1997.07  湖北医科大学,获神经病学硕士学位

      1985.09-1990.07  湖北医科大学,获临床医学学士学位

7、主要工作经历与任职

       2007.11-至今    武汉大学基础医学院病理学与病理生理学系教授、博导

       2006.11-2007.11  武汉大学基础医学院病理学与病理生理学系副教授、硕导

       2005.09-2006.11  澳大利亚悉尼大学医学院病理系,访问学者

       2002.09-2005.09  广州军区武汉总医院神经内科,副主任医师,副教授,硕导

       2000.07-2002.09  武汉大学生命科学院,博士后

8、目前主要科学研究领域和兴趣 

       主要探讨癫痫、多发性硬化症等神经系统离子通道病的发病机制,并针对新发现的离子通道药物靶标开展多肽药物研发,揭示多肽毒素与神经系统离子通道病相关的膜通道及受体相互作用机制。同时,在国内外率先开展了将人泡沫病毒作为载体进行神经退行性疾病的基因治疗研究。研究工作获得国家基金委、科技部、教育部等部委的持续资助,先后主持国家自然科学基金5项、省部级课题6项,同时参与国家科技部973计划项目及重大新药创制专项课题的研究。共发表SCI论文四十余篇,并参与多部专著(含英文专著一部)的编写。研究成果获国家专利2项,军队科技进步三等奖、湖北省自然科学三等奖、武汉市科技进步二等奖、湖北省自然科学优秀学术论文一等奖各1项。2004年荣获湖北省青年杰出人才基金资助,2007年入选教育部新世纪优秀人才计划,并担任中国病理生理生理学会理事、湖北省暨武汉市病理生理学会副理事长等学术职务。

9、教学情况

       系统承担不同专业医学本科生、研究生的病理生理学理论和实验教学,主编教材1部,参编教材3部,发表教学论文5篇,主持省级教学研究项目1项,并作为骨干教师参与医学机能实验学国家级教学团队,已培养博士、硕士研究生各10余名

10、近5年代表性论文

        1.Zhongcheng Wang, Yuanteng Fan, Jian Xu, Liang Li, Duanhe Heng, Song Han, Jun Yin, Biwen Peng, Wanhong Liu, Xiaohua He*. Transcriptome Analysis of the Hippocampus in Novel Rat Model of Febrile Seizures PLoS One. 2014, 9(4):e95237. doi: 10.1371

        2.Yongjuan Liu, Chong Fu, Suying Wu, Xiong Chen, Yingying Shi, Bingfei Zhou, Lianglu Zhang, Fengfeng Zhang, Zhihao Wang, Yingying Zhang, Chengpeng Fan, Song Han, Jun Yin, Biwen Peng, Wanhong Liu, Xiaohua He*. A Novel Finding for Enterovirus Virulence from the Capsid Protein VP1 of EV71 Circulating in Mainland China. Virus Genes. 2014, 48(2):260-72

        3.Yingying Zhang, Xiong Chen, Haiwei Lian, Jianmiao Liu, Beiyan Zhou, Song Han, Biwen Peng, Jun Yin, Wanhong Liu, Xiaohua He*. MicroRNA-503 acts as a tumor suppressor in glioblastoma for multiple antitumor effects by targeting IGF-1R. Oncology Reports. 2014, 31(3):1445-52.

        4.Wenxian Huang, Jiawei Min, Yuqiang Liu, Xiaohua He*, Biwen Peng. Expression of TRPV1 in the C57BL/6 mice brain hippocampus and cortex during development. Neuroreport. <http://www.ncbi.nlm.nih.gov/pubmed/24488030> 2014, 16;25(6):379-85

        5.Jian Xu, Yuanteng Fan, Liang Li, Yanyan Qiu, Zhongcheng Wang, Song Han, Jun Yin, Wanhong Liu, Biwen Peng, Xiaohua He*. Hyperthermia-induced seizures: Development of hyperthermia-prone and hyperthermia-resistant rats. Epilepsy Research. 2013,106(3):311-317

        6.Jiawei Min, Wanhong Liu, Xiaohua He*, Biwen Peng. Different types of toxins targeting TRPV1 in pain. Toxicon. 2013, 71: 66–75

        7.Jinzhi Lu, Xiong Chen, Yingying Zhang, Jian Xu, Lianglu Zhang, Zhi Li, Wanhong Liu, Jingping Ouyang, Song Han, Xiaohua He*. Astragalus polysaccharide induces anti-inflammatory effects dependent on AMPK activity in palmitate-treated RAW264.7 cells. International Journal of Molecular Medicine. 2013, 31(6):1463-1470

        8.Zhi Li, Wanhong Liu, Song Han, Biwen Peng, Jun Yin, Yingliang Wu, Xiaohua He*, Wenxin Li. Selective Inhibition of CCR7_ Effector Memory T Cell Activation by a Novel Peptide Targeting Kv1.3 Channel in a Rat Experimental Autoimmune Encephalomyelitis Model. Journal of Biological Chemistry. 2012, 287(35):29479-29494

        9.Yuan He, Qiang Wu, Zhipeng Xu, Qianqian Wang, Weili Wang, Dezhong Li, Wanhong Liu, Xiaohua He*. Hereditary Neuropathy with Liability to Pressure Palsy: An Investigation in a Rare and Large Chinese Family. European Neurology. 2012, 68:322-328

        10.Zhihao Wang, Bo Yang, Lanlan Dong, Biwen Peng, Xiaohua He*, Wanhong Liu. A novel oncoprotein Pirh2: rising from the shadow of MDM2. Cancer Science. 2011,102:909-917

        11.Fang Yu, Yanlan Liu, Yuncui Wang, Jun Yin, Hui Wang, Wanhong Liu, Biwen Peng, Xiaohua He*. Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures. Epilepsy Research. 2011,97:64-72

        12.Song Han, Youtian Hu, Ruhong Zhang, Hong Yi, Jingjing Wei, Yingliang Wu, Zhijian Cao, Wenxin Li, Xiaohua He*. ImKTx88, a novel selective Kv1.3 channel blocker derived from the scorpion Isometrus maculates. Toxicon. 2011, 57:348-355

        13.Yingying Zhang, Yongjuan Liu, Guoguo Zhu, Yanyan Qiu, Biwen Peng, Jun Yin, Wanhong Liu, Xiaohua He*. Foamy virus: an available vector for gene transfer in neural cells and other non-dividing cells. Journal of NeuroVirology. 2010, 16:419-426

        14.Wanhong Liu, Zhongchun Liu, Li Liu, Zheman Xiao, Xiongbin Cao, Zhijian Cao, Lu Xue, Xiaohua He*, Wenxin Li. A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury. Neuroscience Letters. 2008, 432: 13-18.

        15.Xiaohua He, Edith V. Sullivan, Roger K. Stankovic, Clive G.Harper, Adolf Pfefferbaum. Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus callosum ultra structure. Neuropsychopharmacology. 2007, 32: 2207-2216

        16.Wanhong Liu, Zhongchun Liu, Xiongbin Cao, Zhijian Cao, Lu Xue, Fan Zhu, Xiaohua He*, Wenxin Li. Recombinant human foamy virus, a novel vector for neurological disorder gene therapy, drive production of GAD in cultured astrocytes. Molecular Therapy. 2007, 15: 1834-1841