ENGLISH|院长信箱|书记信箱
师资队伍
汪长华

1、职称职务:教授、博士生导师、病理生理学教研室主任汪长华登记照

2、学科专业:病理生理学

3、研究方向: 代谢综合征

4、联系电话: 027-68759846

5、Email: chwang0525@whu.edu.cn

6、学习经历

  武汉大学医学院内科学博士

7、主要工作经历与任职

  2008年10月-至今:病理生理学教研室副教授、教授、副主任、主任

  2014年1月-至今,美国University of South Dakota Sanford School of Medicine, Research Assistant Professor

  2010年10月-2011年9月,美国University of South Dakota Sanford School of Medicine,访问研究科学家(Visiting Research Scientist)

  2004年7月-2008年9月,美国University of Texas Health Science Center at San Antonio药理学系,研究科学家(Research Scientist)

  2003年3月-2003年8月,法国Henri Poincare Université, Nancy 1大学药学院,高级访问学者

2002年5月-2004年6月:基础医学院生理学教研室副教授、副主任(牵头)

8、目前主要科学研究领域和兴趣

  ①阐明糖尿病发生、发展的分子机制, 尤其是胰岛素信号转导、脂联素信号转导的分子机制;②探讨蛋白质质量控制在重大疾病,如糖尿病、心血管等疾病发生中的作用;③探讨糖尿病与肿瘤的相互关系,及其潜在的机制。拟通过细胞和动物复制疾病模型,采用转基因或基因敲除鼠、分子生物学、形态学等多种手段探讨糖尿病的发生机制,及其与心血管疾病和肿瘤等疾病的相互关系。

9、教学情况

  从事病理生理学理论和实验教学

10、近5年代表性论文

  1. Changhua Wang, Xuejun Wang. The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity. Biochim Biophys Acta. 2014 Aug 1. pii: S0925-4439(14)00249-X. doi: 10.1016/j.bbadis.2014.07.028. [Epub ahead of print].

  2. Zongwen Tian, Changhua Wang, Chengjun Hu, Yihao Tian, Jinbao Liu, Xuejun Wang. Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes. PLoS One. 2014 Jun 24;9(6):e100715.

  3. Shahzad Khan, Changhua Wang. ER stress in adipocytes and insulin resistance: Mechanisms and significance. Molecular Medicine Reports. In press.

  4. Jiyoon Ryu, Amanda K. Galan, Xiaoban Xin, Feng Dong, Muhammad A. Abdul-Ghani, Lijun Zhou, Changhua Wang, Cuiling Li, Bekke M. Holmes, Lauren B. Sloane, Steven N. Austad, Shaodong Guo, Nicolas Musi, Ralph A. DeFronzo, Chuxia Deng, Morris F. White, Feng Liu, Lily Q. Dong. APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor. Cell Rep. 2014 May 22;7(4):1227-38.

  5. Guannan Wang, Zhiliang Xu, Changhua Wang, Feng Yao, Juanjuan Li, Chuang Chen, and Shengrong Sun. Differential phosphofructokinase-1 isoenzyme patterns associated with glycolytic efficiency in human breast cancer and paracancer tissues. Oncol Lett. 2013 Dec;6(6):1701-1706.

  6. Shan Zhu, Feng Yao, Wenhuan Li, Jinnan Wan, Yimin Zhang, ZhaoTang, Shahzad Khan, Changhua Wang, Shengrong Sun. PKCtheta-dependent activation of the ubiquitin proteasome system is responsible for high glucose-induced human breast cancer MCF-7 cell proliferation, migration and invasion. Asian Pac J Cancer Prev. 2013;14(10):5687-92.

  7. Yumin Liu, Xiong Wang, Ahmed Nawaz, Zhaohong Kong, Yan Hong, Changhua Wang, Junjian Zhang. Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. Acta Pharmacol Sin. 2011;32(12):1475-82.

  8.?Sathyaseelan S. Deepa, Lijun Zhou, Jiyoon Ryu, Changhua Wang, Xuming Mao, Cai Li, Ning Zhang, Nicolas Musi, Ralph A. DeFronzo, Feng Liu and Lily Q. Dong. APPL1 Mediates Adiponectin-Induced LKB1 Cytosolic Localization Through the PP2A-PKC{zeta} Signaling Pathway. Mol Endocrinol. 2011;25(10):1773-85.

  9. Si Sun, Yumin Liu, Jinzhi Lu, Ahmed Omar, Shengrong Sun, Yongyi Bi, and Changhua Wang*. The inhibitory effect of PKCtheta on adiponectin expression is mediated by ERK in 3T3-L1 adipocytes. J Endocrinol Invest. 2011;34(1): 8-15.

  10. Shengrong Sun, Xiong Wang, Changhua Wang*, Ahmed Nawaz, Wen Wei, Juanjuan Li, Lijun Wang, and De-Hua Yu. Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells. Planta Medica. 2011;77(2):141-145.

  11.Shichong Liao, Jinxin Li, Lijun Wang, Yimin Zhang, Changhua Wang, Mingbo Hu, Biao Ma, Geng Wang, Shengrong Sun. Type 2 Diabetes Mellitus and Characteristics of Breast Cancer in China.? Asian Pac J Cancer Prev. 2010;11(4):933-937.

  12.Xiong Wang, Wanqui Yu, Ahmed Nawaz, Feng Guan, Shengrong Sun, and ChanghuaWang*. Palmitate induced insulin resistance by PKCtheta-dependent activation of mTOR/S6K pathway in C2C12 myotubes. Exp Clin Endocrinol Diabetes. 2010;118(9):657-661.

  13. Changhua Wang, Xiaoban Xin, Ruihua Xiang, Fresnida J. Ramos, Meilian Liu, Hak Joo Lee, Hongzhi Chen, Xuming Mao, Chintan K. Kikani, Feng Liu, and Lily Q. Dong. Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells. J Biol Chem. 2009;284 (46):31608-31615.