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师资队伍
李长勇

1、职称职务:博士、副教授、硕导、系副主任

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2、学科专业:生理学

3、研究方向:肝病的天然免疫学机制

4、联系电话:

5Emaillichangyong@whu.edu.cn

6、学习经历:

2009年在首都医科大学细胞生物学专业获得博士学位。2015.4-2016.4 在美国加州大学洛杉矶分校(UCLA)从事博士后研究。

7、主要工作经历与任职

2011.10-今 武汉大学基础医学院生理学系讲师、副教授

2009.8-2011.9 首都医科大学基础医学院细胞生物学系讲师

8、目前主要科学研究领域和兴趣

消化生理(肝病的天然免疫学机制)

9、教学情况:

承担临床医学五年制、5+3、八年制和口腔、护理、药学等专业《生理学》、《组织与功能》、《机能实验学一》和留学生《Physiology》等课程。

10、代表性论文

1) Li C, Zheng S, You H, Liu X, Lin M, Yang L, Li L. Sphingosine 1-phosphate (S1P)/S1P receptors is involved in human liver fibrosis by action on hepatic myofibroblasts motility.J Hepatol2011; 54(6):1205-1213.

2) Li C, Kong Y, Wang H, Wang S, Yu H, Liu X, Yang L, Jiang X, Li L, Li L. Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis.J Hepatol2009; 50(6):1174-1183.

3) Li C, Jiang X, Yang L, Liu X, Yue S, Li L. Involvement of sphingosine 1-phosphate (S1P)/S1P(3) signaling in cholestasis-induced liver fibrosis.Am J Pathol2009; 175(4):1464-1472.

4) Qu M, Cui J, Zhu J, Ma Y, Yuan X, Shi J, Guo D,Li C*(Corresponding author). Bone marrow-derived mesenchymal stem cells suppress NK cell recruitment and activation in PolyI:C-induced liver injury.Biochem Biophys Res Commun 2015; 466(2):173-9.

5) Li C, Hu M, Wang Y, Lu H, Deng J, Yan X. Hydrogen sulfide preconditioning protects against myocardial ischemia/reperfusion injury in rats through inhibition of endo/sarcoplasmic reticulum stress.Int J Clin Exp Pathol2015; 8(7):7740-51.

6) Yue S, Zhu J, Zhang M, Li C, Zhou X, Zhou M, Ke M, Busuttil RW, Ying QL, Kupiec-Weglinski JW, Xia Q, Ke B.The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury.Hepatology 2016 Jul 30. doi: 10.1002/hep.28739. [Epub ahead of print]

7) Han Z, Zhu T, Liu X,Li C, Yue S, Liu X, Yang L, Yang L, Li L. 15-Deoxy-Δ(12,14) -prostaglandin J(2) reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury.Hepatology2012; 56(1):350-360.

8) Liu X, Yue S,Li C, Yang L, You H, Li L. Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation.J Cell Physiol2011; 226(9):2370-2377.

9) Liu X, Yu H, Yang L,Li C, Li L. 15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines.Eur J Cell Biol2012; 91(8):654-661.

10) Jiang S, Shi Z,Li C, Ma C, Bai X, Wang C. Hydroxysafflor yellow A attenuates ischemia/reperfusion-induced liver injury by suppressing macrophage activation. Int J Clin Exp Pathol2014; 7(5):2595-2608.

11) Yang L, Chang N, Liu X, Han Z, Zhu T,Li C, Yang L, Li L. Bone Marrow-Derived Mesenchymal Stem Cells Differentiate to Hepatic Myofibroblasts by Transforming Growth Factor-β1 via Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis.Am J Pathol2012; 181(1):85-97.