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师资队伍
何春江

1、职称职务:副教授,博导

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2、学科专业:遗传与生物信息学

3、实验室位置:基础医学院1号2楼东侧医学遗传学系

4、联系电话:027 68759702 (O)

5、Email:che@whu.edu.cn

6、学习经历:

2003.9 – 2008.6:武汉大学生命科学学院,细胞生物学,博士

1999.9 – 2003.6:武汉大学生命科学学院,生物技术,学士

7、主要工作经历与任职

2009.2-2012.4 芝加哥大学医学院血液与肿瘤部 博士后 导师:Jianjun Chen & Janet D. Rowley

2012.5-2013.12 斯坦福大学医学院心血管与干细胞研究所 博士后 导师:Joseph Wu

2014.3至今 武汉大学基础医学院 副教授,博士生导师

8、研究方向:

开发生物信息学工具和数据库,结合实验方法,研究白血病和癌症转录组及免疫组的调控与功能,筛选新的药物靶点和免疫治疗靶标。

9、学术兼职:

Nucleic Acids Research, Briefings in Bioinformatics, Genomics, Plos One, Inflammatory Bowel Diseases, Biomed Research International, Current Bioinformatics等SCI期刊审稿人。

10、获奖、荣誉:

2016年获武汉大学医学部朱裕璧医学奖

2014年入选武汉大学珞珈青年学者

11、研究资助:

国家自然科学基金面上项目 circ-AFF2调控PRC2复合物介导的AML发生发展机制研究2019.1- 2022. 12 主持

国家自然科学基金青年项目LncRNA-LINC01268通过激活HDAC2促进急性髓性白血病增殖的分子机制研究 2016.1-2018.12 主持

国家科技重大专项 艾滋病和病毒性肝炎等重大传染病防治(子课题) 基于大数据分析的风险评估和预警预测2018.1-2020.12  骨干

湖北省自然科学青年基金 基于生物信息学的急性髓性白血病lncRNA与mRNA作用网络的建立与验证 2015.1-2016.12 主持

中央高校自主科研青年项目 基于生物信息学的急性髓性白血病lncRNA与mRNA作用网络的建立与验证 2015.1-2016.12 主持

中央高校自主科研交叉项目 癌症特异环状RNA剪切数据库的构建 2018.1.-2019.12 主持

12、代表性论著 (*一作,#通讯):


1. Xiao S*, Cao S*, Huang Q*, Xia L*, Deng M, Yang M, Jia G, Liu X, Shi J, Wang W, Li Y, Liu S, Zhu H, Tan K, Luo Q, Zhong M#, He C#, Xia L#. The RNA N(6)-methyladenosine modification landscape of human fetal tissues. Nature Cell Biology. 2019 Apr 29. doi: 10.1038/s41556-019-0315-4.


2. Feng J*#, Chen K*, Dong X*, Xu X, Jin Y, Zhang X, Chen W, Han Y, Shao L, Gao Y, He C#. Genome-wide identification of cancer-specific alternative splicing in circRNA. Molecular Cancer. 2019 Mar 8; 18(1):35. doi: 10.1186/s12943-019-0996-0.


3. Han Y*, Feng J*, Xia L*, Dong X, Zhang X, Zhang S, Miao Y, Xu Q, Xiao S, Zuo Z, Xia L, He C#. CVm6A: A Visualization and Exploration Database for m6As in Cell Lines. Cells. 2019 Feb 17; 8(2). pii: E168. doi: 10.3390/cells8020168.


4. Feng J*, Xiang Y*, Xia S*, Liu H, Wang J, Ozguc F, Lei L, Kong R, Diao L, He C#, Han L#. CircView: a visualization and exploration tool for circular RNAs. Briefings in Bioinformatics. 2018 Nov 27. doi: 10.1093/bib/bbx070.


5. Lei L*, Xia S*, Liu D*, Li X*, Feng J, Zhu Y, Hu J, Xia L, Guo L, Chen F, Cheng H, Chen K, Hu H, Chen X, Li F, Zhong S, Mittal N, Yang G, Qian Z, Han L#, He C#. Genome-wide characterization of lncRNAs in acute myeloid leukemia. Briefings in Bioinformatics. 2018 Jun 20. doi: 10.1093/bib/bbx007.


6. Xia S*, Feng J*, Chen K*, Ma Y, Gong J, Cai F, Jin Y, Gao Y, Xia L, Chang H, Wei L, Han L#, He C#. CSCD: A database for cancer-specific circular RNAs. Nucleic Acids Research. 2018 Jan 4. doi: 10.1093/nar/gkx863. WOS高被引论文


7. Xia S*, Feng J*, Lei L, Hu J, Xia L, Wang J, Xiang Y, Liu L, Zhong S, Han L#, He C#. Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Briefings in Bioinformatics. 2017 Nov 1. doi: 10.1093/bib/bbw081. WOS高被引论文


8. He C*#, Hu H*, Wilson KD*, Wu H, Feng J, Xia S, Churko J, Qu K, Chang HY, Wu JC#. Systematic Characterization of Long Non-Coding RNAs Reveals the Contrasting Coordination of Cis- and Trans- Molecular Regulation in Human Fetal and Adult Heart. Circulation Cardiovascular Genetics. 2016 Apr. pii: CIRCGENETICS.115.001264.


9. Li Z*, Herold T*, He C*, Valk PJ, Chen P, Jurinovic V, Mansmann U, Radmacher MD, Maharry KS, Sun M, Yang X, Huang H, Jiang X, Sauerland MC, Büchner T, Hiddemann W, Elkahloun A, Neilly MB, Zhang Y, Larson RA, Le Beau MM, Caligiuri MA, Döhner K, Bullinger L, Liu PP, Delwel R, Marcucci G, Lowenberg B, Bloomfield CD, Rowley JD, Bohlander SK, Chen J. Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study. Journal of Clinical Oncology. 2013 Mar 20;31(9):1172-81. doi: 10.1200/JCO.2012.44.3184.


10. He C*, Li Z*, Chen P*, Huang H, Hurst LD, Chen J. Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution. Nucleic Acids Research. 2012 May;40(9):4002-12. doi: 10.1093/nar/gkr1312.


11. Mi S*, Li Z*, Chen P*, He C*, Cao D, Elkahloun A, Lu J, Pelloso LA, Wunderlich M, Huang H, Luo RT, Sun M, He M, Neilly MB, Zeleznik-Le NJ, Thirman MJ, Mulloy JC, Liu PP, Rowley JD, Chen J. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3710-5. doi: 10.1073/pnas.0914900107.


12. He C*, Zhou F, Zuo Z, Cheng H, Zhou R. A global view of cancer-specific transcript variants by subtractive transcriptome-wide analysis. PLoS One. 2009;4(3):e4732. doi: 10.1371/journal.pone.0004732.


13. He C*, Cheng H, Zhou R. GATA family of transcription factors of vertebrates: phylogenetics and chromosomal synteny. Journal of Biosciences. 2007 Dec;32(7):1273-80.


14. He C*, Zuo Z, Chen H, Zhang L, Zhou F, Cheng H, Zhou R. Genome-wide detection of testis- and testicular cancer-specific alternative splicing. Carcinogenesis. 2007 Dec;28(12):2484-90.