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师资队伍
汪长华

1、职称职务教授、博导、教研室主任68B92、学科专业:病理生理学

3、研究方向:代谢性疾病的分子机制

4、实验室位置:基础医学院1号楼3楼

5、Email:chwang0525@whu.edu.cn

6、学习经历:

1998.09 – 2001.06 武汉大学医学院,内科学,博士

1988.09-1991.06 湖北医科大学,病理生理学,硕士

1983.09-1988.06 湖北医科大学,临床医学,学士

7、主要工作经历与任职:

2001.06~至今 武汉大学基础医学院,副教授、教授,教研室副主任、主任

2014.01 – 2015.08 The University of South Dakota Sanford Medical College,Assistant Professor Research

2010.10 – 2011.09 The University of South Dakota Sanford Medical College,Visiting Research Scientist

2004.07 – 2008.09 University of Texas Health Science Center at San Antonio,Research Scientist

2003.04 – 2003.08 Henri Poincare Université, Nancy 1, Visiting Associate Professor

1993.01 – 1998.08 长江大学医学院,副教授

1991.07 – 1992.12 荆州市第一人民医院,主治医师

8、目前主要科学研究领域和兴趣:

研究重点集中在阐明代谢性疾病发生、发展的分子机制。率先揭示了脂联素 (adiponectin) 信号转导、及其胰岛素增敏效应的分子机制,其关键论文均发表在著名的J Biol. Chem.杂志上,单篇第一作者SCI论文它引次数已达177次(Goggle citation; 2017-01-30)。由于代谢异常是心血管疾病、肿瘤等疾病发生的独立危险因素,本课题组也展开了对代谢异常与心肌病、乳腺癌、肝癌间相关性的研究。研究领域包括: (1)糖尿病发生发展的分子机制,(2)糖尿病心肌病的分子机制,(3)代谢异常与乳腺癌、肝癌相关性研究。先后主持国家自然科学基金项目3项,公开发表SCI收录学术论文40余篇。

9、主要学术兼职:

Frontiers in Pharmacology - Section “Cardiovascular and Smooth Muscle Pharmacology”,Associate Editor

10、教学情况:

承担医学相关专业本科生(含五年制、七年制、八年制各专业)、硕士生、博士生等不同层次学生的病理生理学理论和实验教学工作。培养病理生理学硕士、博士研究生。

11、获奖及荣誉:

12、近五年主要代表性论文:

1.  Li M, Zhang Y, Cao Y, Zhang D, Liu L, Guo Y, Wang C*. Icariin ameliorates palmitate-induced insulin resistance through reducing thioredoxin-interacting protein (TXNIP) and suppressing ER stress in C2C12 myotubes. Front. Pharmacol. 2018; 9:1180.

2. Ye M, Qiu H, Cao Y, Zhang M, Mi Y, Yu J, Wang C*. Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum. Front Pharmacol. 2017;8:148.

3. Jiang P, Zhang D, Qiu H, Yi X, Zhang Y, Cao Y, Zhao B, Xia Z, Wang C*. Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCδ-dependent inhibition of osteopontin. Clin Exp Pharmacol Physiol. 2017;44(7):760-770.

4. Ding Y, Zhang D, Wang B, Zhang Y, Wang L, Chen X, Li M, Tang Z, Wang C*. APPL1-mediated activation of STAT3 contributes to inhibitory effect of adiponectin on hepatic gluconeogenesis. Mol Cell Endocrinol. 2016;433:12-19.

5. Zhang D, Zhang Y, Ye M, Ding Y, Tang Z, Li M, Zhou Y, Wang C*. Interference with Akt signaling pathway contributes curcumin-induced adipocyte insulin resistance. Mol Cell Endocrinol. 2016;429:1-9.

6. Khan S, Zhang D, Zhang Y, Li M, Wang C*. Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties. Mol Cell Endocrinol. 2016;428:101-108.

7. Guan F, Ding Y, Zhang Y, Zhou Y, Li M, Wang C*. Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt Degradation. PLoS One. 2016;11(1):e0146553.

8. Wang C, Wang X. The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity. Biochim Biophys Acta. 2015;1852(2):188-194.

9. Zhang Y, Ye M, Chen LJ, Li M, Tang Z, Wang C*. Role of the ubiquitin-proteasome system and autophagy in regulation of insulin sensitivity in serum-starved 3T3-L1 adipocytes. Endocr J. 2015;62(8):673-686.

10. Zhang YM, Li MX, Tang Z, Wang CH*. Wogonin suppresses osteopontin expression in adipocytes by activating PPARα. Acta Pharmacol Sin. 2015;36(8):987-997.