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师资队伍
鄢友娥

1、职称职务:教授、博士生导师

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2、学科专业:药理学

3、研究方向:肥胖及其并发症的发生机制及药物防治;内分泌毒理与药物靶标;

4、联系电话:027-68758665

5、Email: yanyoue@whu.edu.cn

6、学习经历

2002.09 ~ 2006.12 武汉大学医学院药理学系硕博连读研究生,获医学博士学位

1994.09 ~ 1999.07 原湖北医科大学本科生,获医学学士学位

7、主要工作经历与任职

2016.12 ~ 至今 武汉大学基础医学院药理系教授

2010.12 ~ 2016.11 武汉大学基础医学院药理系副教授

2012.09 ~ 2013.09 美国贝勒医学院(Baylor College of Medicine, BCM)儿童营养研究中心(Children's Nutrition Research Center, CNRC)访问学者

2007.12 ~ 2009.11 武汉大学基础医学院药理系讲师

2004. 03 ~ 2006.09 军事医学科学院基础医学研究所访问学者

1999.07 ~ 2002.08 武汉大学中南医院工作

8、目前主要科学研究领域和兴趣

1)肥胖及其并发症的发生机制及药物防治;

2)内分泌毒理与药物靶标;

从脂肪发育、分化及血管生成调控角度研究发育早期(孕期或哺乳期)不良环境对子代肥胖发生的影响及机制,进而寻找肥胖的早期预警标志物及药物干预靶标。

9、教学情况

承担学院各专业药理学中英文(理论、实验)、临床药理学(理论、实验)、机能实验学教学工作,教学效果良好。积极参与本科生教学改革与实践工作,指导本科生申报并获批武汉大学大学生创新计划项目11项,获湖北省大学生优秀科研成果二等奖1项,参编教材4部。.

10、近5年代表性论文

1)Zhang WX, Li YP, Fan J, Chen HJ, Li GL, Ouyang YQ,Yan YE*.Perinatal Nicotine Exposure Increases Obesity Susceptibility by Peripheral Leptin Resistance in Adult Female Rat Offspring. Toxicology Letters. 2018;283:91-99.

2)Li GL, Chen HJ, Zhang WX, Tong Q,Yan YE*. Effects of maternal omega-3 fatty acids supplementation during pregnancy/lactation on body composition of the offspring: A systematic review and meta-analysis. Clin Nutr. 2017 Aug 10. pii: S0261-5614(17)30269-8. doi: 10.1016/j.clnu.2017.08.002.

3)Fan J, Zhang WX, Rao YS, Xue JL, Wang FF, Zhang L,Yan YE*. Perinatal Nicotine Exposure Increases Obesity Susceptibility in Adult Male Rat Offspring by Altering Early Adipogenesis. Endocrinology, 2016,157(11):4276-86.

4)Fan J, Ping J, Xiang J, Rao YS, Zhang WX, Chen T, Zhang L,Yan YE*. Effects of prenatal and lactation nicotine exposure on glucose homeostasis, lipogenesis and lipid metabolic profiles in mothers and offspring. Toxicology Research, 2016, 5, 1318-28.

5)Zhang WX, Fan J, Ma J, Rao YS, Zhang L,Yan YE*. Selection of Suitable Reference Genes for Quantitative Real-Time PCR Normalization in Three Types of Rat Adipose Tissue. International Journal Of Molecular Sciences, 2016 22;17(6). pii: E968.

6)Liu L, Wang JF, Fan J, Rao YS, Liu F,Yan YE*, Wang H. Nicotine Suppressed Fetal Adrenal StAR Expression via YY1 Mediated-Histone Deacetylation Modification Mechanism. International Journal Of Molecular Sciences, 2016 3;17(9). pii: E1477.

7)Fan J, Ping J, Zhang WX, Rao YS, Liu HX, Zhang J,Yan YE*.Prenatal and lactation nicotine exposure affects morphology and function of brown adipose tissue in male rat offspring. Ultrastructural Pathology, 2016, 40(5):288-95.

8)Yan YE, Liu L, Wang JF, Liu F, Li XH, Qin HQ, Wang H.Prenatal nicotinic exposure suppresses fetal adrenal steroidogenesis via steroidogenic factor 1 (SF-1) deacetylation. Toxicol Appl Pharmacol. 2014;277(3):231-41.

9)Feng JH,Yan YE(Co-first author), Liang G, Liu YS, Li XJ, Zhang BJ, Chen LB, Yu H, He XH, Wang H. Maternal and fetal metabonomic alterations in prenatal nicotine exposure-induced rat intrauterine growth retardation. Mol Cell Endocrinol. 2014;394(1-2):59-69.