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师资队伍
熊海蓉

1、职称职务副教授,硕士生导师5449

2、学科专业:病原生物学

3、研究方向:病毒感染的致病机制与防治技术研究

4、实验室位置:基础医学院医学病毒学研究所1楼

5、Email:hrxiong@whu.edu.cn

6、学习经历:

1997.9-2002.6 武汉大学医学院, 医学学士

2002.9-2009.6 武汉大学基础医学院, 病原生物学系,博士

2005.6-2009.3 Medical College of Georgia,联合培养博士

7、主要工作经历与任职:

2009.7-2012.11 武汉大学基础医学院 讲师

2012.12-至今 武汉大学基础医学院 副教授

8、目前主要科学研究领域和兴趣:

从事病毒感染的致病机制与防治技术研究,主要包括人类免疫缺陷病毒(HIV)和汉坦病毒(HV)等多种病毒的感染与免疫机制研究、人类重要病毒性传染病(HFRS、AIDS等)的分子流行病学研究、抗病毒药物研究(流感病毒、疱疹病毒、柯萨奇病毒、呼吸道合胞病毒、轮状病毒、EV71、汉坦病毒等常见病毒)。

9、主要学术兼职:

10、教学情况:

一直从事本科生和研究生的教学工作,现承担的教学任务有全校通识课 (艾滋病防治、性传播疾病与青春期健康)、本科生必修课(组织与功能、实验室安全)以及研究生通开课(实验室生物安全、高级分子与细胞生物学、生物医学技术、临床微生物学等)。

11、获奖及荣誉:

12、近五年主要代表性论文:

1. Li MK, Liu YY, Wei F, Shen MX, Zhong Y, Li S, Chen LJ, Ma N, Liu BY, Mao YD, Li N, Hou W, Xiong HR*, Yang ZQ*. Antiviral activity of arbidol hydrochloride against herpes simplex virus type in vitro and in vivo. International Journal of Antimicrobial Agents. 2018 Jan;51(1):98-106 (co-corresponding author)

2. Chen QZ, Luo F, Lu MX, Li N, Teng Y, Huang QL, Zhu N, Wang GY, Yue M, Zhang Y, Feng Y, Xiong HR*, Hou W*. HTNV-induced upregulation of miR-146a in HUVECs promotes viral infection by modulating pro-inflammatory cytokine release. Biochemical and Biophysical Research Communications. 2017 Nov 4;493(1):807-813. ( co-corresponding author)

3. Chen XP§, Xiong HR§, Zhu N, Chen QZ, Wang H, Zhong CJ, Wang MR, Lu S, Luo F, Hou W*. Lack of association between integrin αvβ3 gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. Virologica Sinica. 2017 Feb;32(1):73-79.(co-first author)

4. Liu YY, Chen LJ, Zhong Y, Shen MX, Ma N, Liu BY, Luo F, Hou W, Yang ZQ, Xiong HR*. Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo. Acta Pharmacologica Sinica. 2016 Apr;37(4):497-504

5. Xiong HR, Zhang YH, Deng Kan, Liu Q, Liu YY, Luo F, Hou W, Yang ZQ*. Antiviral activity and mechanism of action of arbidol against Hantaan virus infection. Tropical Journal of Pharmaceutical Research. 2016; 15 (7): 1439-1445

6. Liu Q§, Xiong HR§, Lu L, Liu YY, Luo F, Hou W, Zhan-Qiu Yang. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta Pharmacologica Sinica. 2013 Aug 5;34(8):1075-83 (co-first author)

7. Xiong HR, Shen YY, Lu L, Hou W, Luo F, Xiao H, Yang ZQ. The Inhibitory Effect of Rheum palmatum Against Coxsackievirus B(3)in Vitro and in Vivo. The American Journal of Chinese Medicine. 2012;40(4):801-12.

8. Xiong HR, Lee RJ, Haura EB, Edward JG, Dynan WS, Li S. Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunit. International Journal of Radiation Oncology Biology Physics. 2012;Jul 1;83(3):1023-30.

9. Xiong HR, Li Q, Chen W, Liu DY, Ling JX, Liu J, Liu YJ, Zhang Y, Yang ZQ. Specific Humoral Reaction of Hemorrhagic Fever with Renal Syndrome (HFRS) Patients in China to Recombinant Nucleocapsid Proteins from European Hantaviruses. European journal of clinical microbiology & infectious diseases.  2011 May;30(5):645-51.

10. Xiong HR, Luo J, Hou W, Xiao H, Yang ZQ. The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo. Journal of ethnopharmacology, 2011 Jan 27;133(2):718-23.