武栋成

8姓名:武栋成                                                             

1.任职与兼职:

    教授、博士生导师,湖北省楚天学者特聘教授。

2.联系方式:

    联系电话:18627713366

    Email:bcdcwu@hotmail.com

3.研究方向:

    ①   糖尿病肾病肾小球硬化分子机制的研究。

    ②   自体骨髓间充质干细胞移植对急性肾损伤的治疗作用及其分子机制的研究。

4.主要学习工作经历

    1982.9-1987.7:  湖北医学院医学系本科毕业获医学学士

    1990.9-1993.7:  湖北医科大学研究生毕业获医学硕士学位

    1998.9-2000.10:香港科技大学研究生毕业获硕士学位

    2002.9-2005.7:  武汉大学研究生毕业获博士学位

    1993.7-2001.3:湖北医科大学助教、讲师、副教授。

    2001.4-2009.5:加拿大McMaster大学医学院博士后,研究科学家(Research Scientist),

    2009.6-今:武汉大学医学院教授、博士生导师,湖北省楚天学者特聘教授。

5.教学工作:

    目前负责五年制、八年制医学生生物化学的教学。

6.科研工作:

    已招收培养硕士生   名,博士生   名。主持国家自然科学基金   等多项课题,于国内外重要学术期刊上发表论文   余篇

7代表性论著

    1)     Qi S, Wu D. Bone marrow-derived mesenchymal stem cells protect against cisplatin-induced acute kidney injury in rats by inhibiting cell apoptosis. Int J Mol Med 2013, 32(6):1262-1272.

    2)     Jiang PC, Xiong WP, Wang G, Ma C, Yao WQ, Kendell SF, Mehling BM, Yuan XH, Wu DC. A clinical trial report of autologous bone marrow-derived mesenchymal stem cell transplantation in patients with spinal cord injury. Exp Ther Med 2013, 6(1):140-146.

    3)     Du H, Yao W, Fang M, Wu D. ARF triggers cell G1 arrest by a P53 independent ERK pathway. Mol Cell Biochem 2011, 357(1-2):415-422.

    4)     Uttarwar L, Peng F, Wu D, Kumar S, Gao B, Ingram AJ, Krepinsky JC. HB-EGF release mediates glucose-induced activation of the epidermal growth factor receptor in mesangial cells. Am J Physiol Renal Physiol 2011, 300(4):F921-931.

    5)     Wu D, Peng F, Zhang B, Ingram AJ, Gao B and Krepinsky JC. PKCβ1 mediates high glucose-induced Akt activation and TGFβ1 upregulation in kidney mesangial cells. J Am Soc Nephrol 2009, 20(3):554-566.

    6)     Peng F, Wu D, Gao B, Ingram AJ, Zhang B, Chorneyko K, McKenzie R, Krepinsky JC. RhoA/Rho-kinase Contribute to the Pathogenesis of Diabetic Renal Disease. Diabetes 2008, 57(6):1683-1692.

    7)     Peng F, Zhang B, Wu D, Ingram AJ, Gao B, Krepinsky JC. TGFbeta-induced RhoA activation and fibronectin production in mesangial cells require caveolae. Am J Physiol RenalPhysiol 2008, 295(1):F153-164.

    8)     Zhang B, Peng F, Wu D, Ingram AJ, Gao B, Krepinsky JC. Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells. Cellular Signaling 2007, 19(8):1690-1700.

    9)     Wu D, Peng F, Zhang B, Ingram AL, Gao B, Krepinsky JC. Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells. Diabetologia 2007, 50(9):2008-2018.

    10)  F Peng,Wu D, Ingram AJ, Krepinsky JC,.  Stretch-Induced RhoA Activation is Dependent on Caveolae in Mesangial Cells. J Am Soc Nephrol 2007, 18(1):189-198.

    11)  Wu D, Chen B, Parihar K, He L, Fan C, Zhang J, Liu L, Gillis A, Bruce A, Kapoor A, Tang D. ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function. Oncogene 2006, 25(8):1153-1164.

    12)  Li Y*, Wu D*, Chen B, Ingram AJ, He L, Liu L, Zhu D, Kapoor A,  Tang D . ATM activity contributes to the tumor suppressing functions of p14ARF. Oncogene 2004, 23(44):7355-7365.

    13)  Krepinsky JC, Li Y, Peng F, Tang D, Wu D, Chang Y, Liu L, Scholey J, Ingram AJ.  Aktmediates mechanical strain-induced collagen production by mesangial cells.  J Am Soc Nephrol 2005, 16(6):1661-1672.

    14)  Trentin GA, He Y, Wu D, Tang D, Rozakis-Adcock M. Identification of a hTid-1 mutation which sensitizes gliomas to apoptosis. FEBS Lett 2004, 578(3):323-330.

    15)  Krepinsky JC, Ingram AJ, Tang D, Wu D, Liu L, Scholey JW.  Nitric oxide inhibits stretch-induced MAPK activation in mesangial cells through RhoA inactivation. J Am Soc Nephrol 2003, 14(11):2790-2800.

    16)  Hossain GS, van Thienen JV, Werstuck GH, Zhou J, Sood SK, Dickhout JG, de Koning AB, Tang D, Wu D, Falk E, Poddar R, Jacobsen DW, Zhang K, Kaufman RJ, Austin RC.TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the development of atherosclerosis in hyperhomocysteinemia.  J Biol Chem 2003, 278(32):30317-30327.

    17)  Wu D, Ingram A, Lahti JH, Mazza B, Grenet J, Kapoor A, Liu L, Kidd VJ, Tang D.  Apoptotic release of histones from nucleosomes. J Biol Chem 2002, 277(14): 12001-12008.

    18)  Tang D, Wu D, Hirao A, Lahti JM, Liu L, Mazza B, Kidd VJ, Mak TW, Ingram AJ.  ERKactivation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem 2002, 277(15):12710-12717.

    19)  Wu DC, Xiao XQ, Ng AKY, Chen PMY, Chung W, Lee NTK, Carlier PR, Pang YP, Yu ACH, Han YF.  Protection against ischemic injury in primary cultured mouse astrocytes bybis (7)-tacrine, a novel anti-Alzheimer agent. Neurosci Lett 2000, 288(2): 95-98.

    20)  Wu DC, Yu YP, Lee NTK, Yu ACH, Wang JHC, Han YF.  The Expression of Cdk5, p35,p39 and Cdk5 kinase activity in developing, adult and aged rat brains. Neurochem Res 2000, 25(7):923-929.