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Introduction of the department of pathology

Introduction of the department of pathology Hubei Medical College was founded in May 1943,and the department of pathological anatomy in Hubei Medical College was founded by professor Wang Dianxi and professor Wu Anshun in the same year. Professsor Wang Dianxi was the Director of Academic Affairs in Hubei Medical College at the beginning of the new department. In the early 1950s in addition to taking on teaching task, the department of pathology also undertook clinical pathological examination in The First Affiliated Hospital and The Second Affiliated Hospital of Hubei Medical College, Wuhan Third Hospital and Wuhan seventh Hospital in the long term. The department undertook autopsy in Wuchang district, and regularly held clinical pathological conferences. Four universities merged into a new Wuhan university in August 2000, and so the department of pathology, the department of pathophysiology and the department of forensic medicine in former Basic Medical College merged into the department of pathology and pathophysiology. Our department was renamed the teaching and research section of pathology in the department of pathology and pathophysiology of Wuhan University School of Basic Medical sciences. The number of staff in our teaching and research section is 11 at present.
The number of teachers is 8, and the number of technicians is 3. The number of associate professors is 4, and the number of lecturer is 4. The number of senior technicians is 2, and The number of intermediate technician is 1. All teachers have master degree or above, and six of them have doctor degree. The number of teachers over age 45 is 2, and the number between 35 and 45 is 6. Since the establishment of teaching and research section, after several generations of efforts, teaching and research made considerable progress.
Teaching achievements:
1. Since pathology became the first batch of master enrollment major in 1978, our department trained more than 100 master degree candidates.
2. In 2010, Professor Xue Jingling participated in young teacher competition in School of Basic medical sciences and won the second prize.
3. In 2012, Direcor Diao Luming won the gardener award in School of Basic medical sciences. Research achievements: 1.Wang Y, Jiang CQ, Fan LF*. Correlation of Musashi-1, Lgr5 and pEGFR expressions in human small intestinal adenocarcinomas. Tumor Biol. 2015, Mar 14. [Epub ahead of print] 2. Yan Wan, Cong-Qing Jiang , Jing Guan ,Gui-Fang Yang, Jun-Qiu Yue,Hong-Lei Chen, Jing-Ling Xue, Zhi-Gao Xu, Qun Qian, Li-Fang Fan*.Molecular alterations of EGFR in small intestinal adenocarcinoma. Int J Colorectal Dis. 2013; 28(10):1329-1335.
4. Yi Zhang, Xue Yao, Congqing Jiang, Junqiu Yue, Jing Guan, Honglei Cheng, Mohammed Hajirashid, Yan Wang, Li-Fang Fan*. Expression of PI3K, PTEN and Akt in small intestinal quantum dots-based immunofluorescence technology. Cancer Biomark. 2013; 13(4)299-305.
5. Fan L, Levy M, Aguilar CE, Mertens RB, Dhall D, Frishberg DP, Wang HL. Lymph node retrieval from colorectal resection specimens for adenocarcinoma: is it worth the extra effort to find at least 12 nodes? Colorectal Dis. 2011; 13(12):1377-1383.
6. Fan LF, Datta V, Riley-Portuges, Lopategui J, Lin F, Xu HD, Wang HL. EGFR Expression and KRAS Mutation in Cholangiocarcinoma: Implication in EGFR-Targeted Therapie. Mod Pathol. 2010; 23 Supplement, 354A.
7. Fan LF, Mylinh TM, Frishberg DP, Fan X, Dhall D, Bonnie LB, Geller SA, Wang HL. Interobserver and Intraobserver Variability in Evaluating Vascular Invasion in Hepatocellular Carcinoma. J Gastroenterol Hepatol. 2010; 25(9):1556-15561.
8. Fan LF, Dong WG, Jiang CQ, Xia D, Liao F, Yu QF. Expression of putative stem cell genes musashi-1, and β1-integrin in human colorectal adenomas and adenocarcinoma. Int J Colorectal Dis. 2010; 25(1): 17-23.
9.Zhao H, Zhang X, Chen X, Li Y, Ke Z, Tang T, Chai H, Guo AM, Chen H*, Yang J*. Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. Toxicol Appl Pharmacol. 2014, 279(3):311-21.
10.Chen H, Wu S, Lu R, Zhang Y, Zheng Y, Sun J. Pulmonary permeability assessed by fluoresce-labeled dextran instilled intranasally into mice with LPS-induced acute lung injury. PLoS One, 2014,9(7): e101925.
11.Peng J*, Chen HL*, Zhu XB, Yang GF, Zhang ZL, Tian ZQ, Pang DW. Detection of Epstein-Barr virus infection in gastric carcinomas using quantum dot-based fluorescence in-situ hybridization. J Nanosci Nanotechno, 2011,11(11):9725-30.
12.Chen HL, Fan LF, Gao J, Ouyang JP, Zhang YX. Differential expression and function of caveolin-1 gene in non-small cell lung carcinoma. Oncol Rep,2011, 25(2):359-66.
13. Chen HL, Peng J, Zhu XB, Gao J, Xue JL, Wang MW, Xia HS. Detection of EBV in nasopharyngeal carcinoma by quantum dot fluorescent in situ hybridization. Exp Mol Pathol. 2010,89(3):367-71.
14. Chen H, Xue J, Zhang Y, Zhu X, Gao J, Yu B. Comparison of quantum dots immunofluorescence histochemistry and conventional immunohistochemistry for the detection of caveolin-1 and PCNA in the lung cancer tissue microarray. J Mol Histol. 2009, 40(4):261-8.
15. Xue J, Chen H, Diao L, Chen X, Xia D. Expression of caveolin-1 in tongue squamous cell carcinoma by quantum dots. Eur J Histochem. 2010,14;54 (2):e20.
16. Xue J, Chen H, Fan M, Zhu F, Diao L, Chen X, Fan L, Li P, Xia D. Use of quantum dots to detect human papillomavirus in oral squamous cell carcinoma. J Oral Pathol Med. 2009,38 (8):668-71.
17.Chen H, Xue J(Co- first author), Zhang Y, Zhu X, Gao J, Yu B. Comparison of quantum dots immunofluorescence histochemistry and conventional immunohistochemistry for the detection of caveolin-1 and PCNA in the lung cancer tissue microarray. J Mol Histol.2009, 40 (4):261-8.
18. Xue J, Fan M, Wang S, Chen X , Li Y, Wang L. A clinical study of 674 patients with OLP in China. J Oral Pathology Medicine. 2005,34 (8):467-472
19. Wei Guo, Jinyi Liu, Jinlong Jian, Jingxia Li, Yu Wan and Chuanshu Huang*. IKK-b/NFkB p65 Mediates p27kip1 Protein Degradation in Arsenite Response. Biochem Biophys Res Commun. 2014;447(4):563-8
20. Guo W, Yang Z, Xia Q, Liu JY, Li JX, Zhang DY, Shi XL and Huang CS*. Arsenite Stabilizes HIF-1a Protein through p85a-Mediated Up-regulation of Inducible Hsp70 Protein Expression. Cell Mol Life Sci 2011 ;68(3):475-88
21.Li Zhang, Youyou Wang, Min Peng, Qian She, Qunying Xiang, Qing Chen, Zhong Liu,Wei Zhang, Ning Tao, Lixin Qiu, Xinxing Wu. Prevalence and Type Distribution of High-risk Human Papillomavirus Infections among Women in Wufeng County, China. Archives of Gynecology and Obstetrics, 2012; 286 (3):695-699 .
22.Li Zhang, Dangxiao Cheng, Ning Tao, Min Zhao, Fan Zhang, Yulin Yuan, Xiaoping Qiu. Distribution of HLA-A, -B and -DRB1 genes and haplotypes in the Tujia population living in the Wufeng region of Hubei province, China. PLoS One. 2012;7(6):e38774. 2012 Jun 14.
23.Li Zhang, Oh S.Y, Tao Zheng et al. SHP-1 Deficient Mast Cells are Hyperresponsive to Stimulation and Critical in Initiating Allergic Inflammation in the Lung. The Journal of Immunology, 2010 1;184(3):1180-90.
24.Li Zhang, Oh S.Y et al. Role of Protein Tyrosine Phosphatase SHP-1 on Mast Cell Differentiation, Proliferation and Cytokine Production. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009;123( 2) 198-S198
25.Zhu Liqin, Li Hui, Xiong Jinhu, Wang Tongxiang, Ou Xuan, Wei Yun, Wu Xinxing. HPV16E7-HSP70 hybrid DNA vaccine induces E7-specific cytotoxic T cells and antitumor immunity. Wuhan University Journal of Natural Sciences. 2006,11(3):749-755