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李长勇

1、职称职务:博士、副教授、硕导、系副主任

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2、学科专业:生理学

3、研究方向:肝病免疫学机制;干细胞免疫调控与治疗

4、实验室位置:基础医学院11号楼102

5Emaillichangyong@whu.edu.cn

6、学习经历:

2009年在首都医科大学细胞生物学专业获得博士学位。2015.4-2016.4,2018.5-2019.5 在美国加州大学洛杉矶分校(UCLA)从事博士后研究。

7、主要工作经历与任职

2011.10-今 武汉大学基础医学院生理学系 讲师、副教授

2009.8-2011.9 首都医科大学基础医学院细胞生物学系 讲师

8、目前主要科学研究领域和兴趣

主要从事肝脏炎症、非酒精性脂肪肝及肝纤维化/肝硬化的发病机制研究,利用现代细胞与分子生物学技术和模式动物,从分子、细胞、组织、器官及整体水平,深入系统地探讨肝病免疫学发病机制及信号调控网络,为临床上治疗这类肝病提供新的潜在靶标。另外,探讨间充质干细胞在上述肝病中的治疗作用及其免疫调控机制,为干细胞的临床应用奠定理论基础。

9、主要学术兼职:

  湖北省生理学会常务理事;教育部学位中心学位论文通讯评审专家

10、教学情况:

承担临床医学5年制、5+3、8年制和口腔、护理、基础医学等专业《生理学》、《组织与功能》、《机能实验学》、《基础医学综合实验》和留学生《Physiology》等课程。

11、获奖及荣誉

2012年入选武汉大学珞珈青年学者

2010年入选北京市50篇优博论文

2009年获首都医科大学最佳SCI论文奖

12、代表性论文

(1) Li C, Jin Y, Wei S, Sun Y, Jiang L, Zhu Q, Farmer DG, Busuttil RW, Kupiec-Weglinski JW, Ke B*. Hippo signaling controls NLR family pyrin domain containing 3 activation and governs immunoregulation of mesenchymal stem cells in mouse liver injury. Hepatology 2019;70(5):1714-1731. (一区)

(2) Li C, Mingwei Sheng, Yuanbang Lin, Dongwei Xu, Yizhu Tian, Yongqiang Zhan, Longfeng Jiang, Ana J. Coito, Ronald W. Busuttil, Douglas G. Farmer, Jerzy W. Kupiec-Weglinski, and Bibo Ke*. Functional crosstalk between myeloid Foxo1–β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response. Cell Death Differ 2020; doi: 10.1038/s41418-020-00695-7 (一区)

(3) Jin Y#, Li C# (并列第一), Xu D, Zhu J, Wei S, Zhong A, Sheng M, Duarte S, Coito AJ, Busuttil RW, Xia Q, Kupiec-Weglinski JW, Ke B*. Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury. Cell Mol Immunol 2020; 17(12):1245-1256. (一区)

(4) Li C, Zheng S, You H, Liu X, Lin M, Yang L, Li L*. Sphingosine 1-phosphate (S1P)/S1P receptors is involved in human liver fibrosis by action on hepatic myofibroblasts motility. J Hepatol 2011; 54(6):1205-1213. (一区)

(5) Li C, Kong Y, Wang H, Wang S, Yu H, Liu X, Yang L, Jiang X, Li L, Li L*. Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis. J Hepatol 2009; 50(6):1174-1183. (一区)

(6) Li C, Jiang X, Yang L, Liu X, Yue S, Li L*. Involvement of sphingosine 1-phosphate (S1P)/S1P(3) signaling in cholestasis-induced liver fibrosis. Am J Pathol 2009; 175(4):1464-1472.

(7) Zhu Q#, Li C# (并列第一), Wang K, Yue S, Jiang L, Ke M, Busuttil RW, Kupiec-Weglinski JW, Zhang F, Lu L, Ke B*. PTEN-β-catenin signaling modulates regulatory T cells and inflammatory responses in mouse liver ischemia and reperfusion injury. Liver Transpl 2017; 23:813-825.

(8) Xiang E, Han B, Zhang Q, Rao W, Wang Z, Chang C, Zhang Y, Tu C, Li C* (并列通讯), Wu D*. Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Res Ther 2020; 11(1):336.

(9) Sun Y, Yu M, Qu M, Ma Y, Zheng D, Yue Y, Guo S, Tang L, Li G, Zheng W, Wang M, Guo D, Li C*(通讯作者). Hepatitis B virus-triggered PTEN/β-catenin/c-Myc signaling enhances PD-L1 expression to promote immune evasion. Am J Physiol Gastrointest Liver Physiol 2020;318(1):G162-G173.

(10) Chen L, Xiang E, Li C* (并列通讯), Han B, Zhang Q, Rao W, Xiao C, Wu D*. Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Nephrocyte Injury and Proteinuria in a Diabetic Nephropathy Rat Model. J Diabetes Res 2020; 29;2020:8035853.

(11) Qu M, Cui J, Zhu J, Ma Y, Yuan X, Shi J, Guo D, Li C*(通讯作者). Bone marrow-derived mesenchymal stem cells suppress NK cell recruitment and activation in PolyI:C-induced liver injury. Biochem Biophys Res Commun 2015; 466(2):173-9.

(12) Qu M, Yuan X, Liu D, Ma Y, Zhu J, Cui J, Yu M, Li C* (并列通讯), Guo D*. Bone Marrow-Derived Mesenchymal Stem Cells Attenuate Immune-Mediated Liver Injury and Compromise Virus Control During Acute Hepatitis B Virus Infection in Mice. Stem Cells Dev 2017; 26(11):818-827.

(13) Lu L, Yue S, Jiang L, Li C, Zhu Q, Ke M, Lu H, Wang X, Busuttil RW, Ying QL, Kupiec-Weglinski JW, Ke B*. Myeloid Notch1 Deficiency Activates RhoA/ROCK Pathway and Aggravates Hepatocellular Damage In Mouse Ischemic Livers. Hepatology 2018; 67(3):1041-1055.

(14) Yue S, Zhu J, Zhang M, Li C, Zhou X, Zhou M, Ke M, Busuttil RW, Ying QL, Kupiec-Weglinski JW, Xia Q, Ke B*. The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury. Hepatology 2016; 64:1683-1698.

(15) Han Z, Zhu T, Liu X, Li C, Yue S, Liu X, Yang L, Yang L, Li L*. 15-Deoxy-Δ(12,14) -prostaglandin J(2) reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury. Hepatology 2012; 56(1):350-360.

(16) Wang J, Chen J, Liu Y, Zeng X, Wei M, Wu S, Xiong Q, Song F, Yuan X, Xiao Y, Cao Y, Li C, Chen L, Guo M, Shi YB, Sun G*, Guo D*. Hepatitis B Virus Induces Autophagy to Promote its Replication by the Axis of miR-192-3p-XIAP Through NF kappa B Signaling. Hepatology 2019; 69(3):974-992.

(17) Wei S, Wang Q, Zhou H, Qiu J, Li C, Shi C, Zhou S, Liu R, Lu L*. miR-455-3p Alleviates Hepatic Stellate Cell Activation and Liver Fibrosis by Suppressing HSF1 Expression. Mol Ther Nucleic Acids 2019;16:758-769.

(18) Wei S, Zhou H, Wang Q, Zhou S, Li C, Liu R, Qiu J, Shi C, Lu L*. RIP3 deficiency alleviates liver fibrosis by inhibiting ROCK1-TLR4-NF-κB pathway in macrophages. FASEB J 2019;33(10):11180-11193.

(19) Zhou M, Fang H, Du M, Li C, Tang R, Liu H, Gao Z, Ji Z, Ke B, Chen XL*. The Modulation of Regulatory T Cells via HMGB1/PTEN/β-Catenin Axis in LPS Induced Acute Lung Injury. Front Immunol 2019;10:1612.