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2002.9 -2007.6 武汉大学生命科学学院微生物学专业 硕博连读

1995.9 -1999.6 武汉大学生命科学学院生物化学专业 本科


2012.11 – 武汉大学基础医学院病原生物学系 副教授

2010.02 – 2012.01 Dep. of Pharmacology, University of Minnesota, U.S.A. Postdoctoral Academic Staff

2009.11 – 2012.11 武汉大学基础医学院病原生物学系 讲师

2007.08 – 2009.11 武汉大学基础医学院病原生物学系 助教


① HIV感染及其致病机理:主要关注HIV-1潜伏感染状态下的基因表达,特别是miRNA表达谱与基因表达谱的交互作用。细胞miRNA调控大量基因,参与病毒感染及宿主抗病毒过程,潜伏感染或持续性感染状态下,细胞miRNA与细胞的基因、病毒自身基因存在大量互作,并保持一定的平衡。目前“HIV-1自身编码的miRNA参与HIV-1感染及致病机制研究”获得国家自然科学基金等资助。

② 利用小分子调控病毒复制:主要目标是尝试利用多肽、小分子RNA等干扰病毒感染和复制。病毒吸附、基因组复制转录、包括转录本切割等多个步骤均涉及小分子参与,可利用关键分子进行病毒复制抑制干预和复制增强干预。

Research Interests

Dr. Yong Feng and colleagues are engaged in research into the mechanism of viral infection and gene regulation. Many of the miRNAs together with plenty of genes are involved in viral infection and its pathogenesis. We focus on these miRNA profiles, gene regulation profiles, and the complexity between these two systems. Projects are supported by NSFC, Ministry of Education (P.R.C.) and Health Department of Hubei. Ongoing efforts are seeking to: 1) probe the influence of the HIV-1 encoded miRNAs during viral infection, particularly in latent infection; 2) apply small molecules such as small RNAs and peptides to regulate viral replication.




1.Feng Y, Zhang X, Graves P, Zeng Y. A comprehensive analysis of precursor microRNA cleavage by human Dicer. RNA. 2012 Nov;18(11):2083-92. (IF: 5.095)

2.Feng Y, Zhang XX, Song QF, Li TB, Zeng Y. Drosha processing controls the specificity and efficiency of global microRNA expression. 2011. Biochim Biophys Acta 1809, 700-707. (IF: 4.405)

3.Li W, Yang F, Liu Y, Gong R, Feng Y, Liu L, Hu P, Sun W, Kang L, Hao Q, Wu JG, Zhu Y. Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection. Eur J Immunol. 2009, 39(4): 1019-24. (IF:5.103)

4.Feng Y, Wang SQ, Luo FL, Ruan Y, Kang L, Xiang XH, Chao T, Peng GQ, Zhu CL, Mu YX, Zhang XL, and Wu JG. A novel recombinant bacterial vaccine strain expressing dual viral antigens induces multiple immune responses to the Gag and gp120 proteins of HIV-1 in immunized mice. Antiviral Res,2008, 80: 272-279. (IF: 4.301)

5.Peng GQ, Yan Y, Zhu CL, Wang SQ, Yan XH, Lu LL, Li W, Hu J, Wei W, Mu YX, Chen YN, Feng Y, Gong R, Wu KL, Zhang FM, Zhang XL, Zhu Y, and Wu JG. Borna disease virus P protein affects neural transmission through interacting with gamma-aminobutyric acid receptor-associated protein. J. Virol., 2008, 82 (24): 12487-12497. (IF: 5.402)

6.Luo FL#, Feng Y#, Liu M, Li PF, Pan Q, Jeza VT, Xia B, Wu JG, and Zhang XL. Type IVB pilus operon promoter controlling expression of the severe acute respiratory syndrome-associated coronavirus nucleocapsid gene in salmonella enterica serovar typhi elicits full immune response by intranasal vaccination. Clin. Vaccine Immunol, 2007, 14(8): 990-997. (IF: 2.546) (# co-first author)

7.Li PF, Wan Q, Feng Y, Liu M, Wu JG, Chen XW, Zhang XL. Engineering of N-glycosylation of hepatitis C virus envelope protein E2 enhances T cell responses for DNA immunization. Vaccine. 2007, 25: 1544-1551. (IF: 3.766).