牛万宝  教授

职称职务：教授，博士生导师，国家级人才计划入选者

学科专业：人体解剖学与组织胚胎学

研究方向：哺乳动物原始卵泡的形成及发育调控

实验室位置：武汉大学医学部基础医学院3号楼

Email：niuwanbao@whu.edu.cn

学习经历：

2005/09-2009/06 中国农业大学，生物学院，生物科学类专业，学士；

2009/09-2016/06 中国农业大学，生物学院，动物生理系，博士

主要工作经历与任职：

2016/10-2023/12 Carnegie Institute for Science, Department of Embryology (HHMI)，博士后;

2024/01至今，武汉大学，泰康医学院（基础医学院），教授；

2024/01至今，武汉大学，泰康生命医学中心PI

目前主要科学研究领域和兴趣：

作为不可再生的生殖资源，原始卵泡库在形成之初即决定了雌性哺乳动物一生的生育力。原始卵泡形成过少或过度耗竭会引起卵巢早衰等严重的卵巢疾病。在进化上高度保守的合胞体（Germline Cyst）结构对原始卵泡的形成是必需的，合胞体内滋养细胞将细胞器传递至卵母细胞，形成巴尔比亚尼小体（Balbiani body），促进卵母细胞的分化及原始卵泡形成。本课题组将聚焦以下研究方向和科学问题，力图阐明原始卵泡形成及发育的具体分子机制：

1）探索合胞体内细胞器定向传递以及卵母细胞命运决定的分子机制；

2）研究原始卵泡内Balbiani body的高分辨率全景图像，揭示其分子构成和生物学功能；

3）研究卵母细胞内RNA分子在各区域的精细分布、构象及组织规律；

4）研究长期进化过程中两波原始卵泡的发育规律及其生物学意义。

荣誉及获奖：

国家级人才计划入选者

代表性论文

1. Niu, W., & Spradling, A. C. (2022). Mouse oocytes develop in cysts with the help of nurse cells. Cell. https://doi.org/10.1016/j.cell.2022.05.001

2. Niu, W., & Spradling, A. C. (2020). Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary. Proceedings of the National Academy of Sciences, 117(33), 20015–20026. https://doi.org/10.1073/pnas.2005570117

3. Niu, W., Wang, Y., Wang, Z., Xin, Q., Wang, Y., Feng, L., Zhao, L., Wen, J., Zhang, H., Wang, C., & Xia, G. (2016). JNK signaling regulates E-cadherin junctions in germline cysts and determines primordial follicle formation in mice. Development. https://doi.org/10.1242/dev.132175

4. Niu, W., & Spradling, A. C. (2023). Gene X, a key gene for communication between supporting cells and germ cells. (In preparation)

5. Yan, H., Zhang, J., Wen, J., Wang, Y., Niu, W., Teng, Z., Zhao, T., Dai, Y., Zhang, Y., Wang, C., Qin, Y., Xia, G., & Zhang, H. (2018). Cdc42 controls the activation of primordial follicles by regulating PI3K signaling in mouse oocytes. BMC Biology, 16(1). https://doi.org/10.1186/s12915-018-0541-4

6. Feng, L., Wang, Y., Cai, H., Sun, G., Niu, W., Xin, Q., Tang, X., Zhang, J., Wang, C., Zhang, H., & Xia, G. (2016). ADAM10-notch signaling governs the recruitment of ovarian pregranulosa cells and controls folliculogenesis in mice. Journal of Cell Science. https://doi.org/10.1242/jcs.184267

7. Zhao, L., Du, X., Huang, K., Zhang, T., Teng, Z., Niu, W., Wang, C., & Xia, G. (2016). Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Scientific Reports, 6(1). https://doi.org/10.1038/srep23972

8. Teng, Z., Wang, C., Wang, Y., Huang, K., Xiang, X., Niu, W., Feng, L., Zhao, L., Yan, H., & Zhang, H. (2016). Gap junctions are essential for murine primordial follicle assembly immediately before birth. REPRODUCTION, 151(2), 105–115. https://doi.org/10.1530/rep-15-0282

9. Wang, Z., Niu, W., Wang, Y., Teng, Z., Wen, J., Xia, G., & Wang, C. (2015). Follistatin288 regulates germ cell cyst breakdown and primordial follicle assembly in the mouse ovary. PLOS ONE, 10(6). https://doi.org/10.1371/journal.pone.0129643

10. Wang, Y., Teng, Z., Li, G., Mu, X., Wang, Z., Feng, L., Niu, W., Huang, K., Xiang, X., Wang, C., Zhang, H., & Xia, G. (2015). Cyclic AMP in oocytes controls meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary. Development. https://doi.org/10.1242/dev.112755

11. Teng, Z., Wang, C., Wang, Y., Huang, K., Xiang, X., Niu, W., Feng, L., Zhao, L., Yan, H., Zhang, H., & Xia, G. (2015). S100A8, an oocyte-specific chemokine, directs the migration of ovarian somatic cells during mouse primordial follicle assembly. Journal of Cellular Physiology, 230(12), 2998–3008. https://doi.org/10.1002/jcp.25032

12. Wang, Z.-P., Mu, X.-Y., Guo, M., Wang, Y.-J., Teng, Z., Mao, G.-P., Niu, W.-B., Feng, L.-Z., Zhao, L.-H., & Xia, G.-L. (2014). Transforming growth factor-β signaling participates in the maintenance of the primordial follicle pool in the mouse ovary. Journal of Biological Chemistry, 289(12), 8299–8311. https://doi.org/10.1074/jbc.m113.532952

13. Zhang, C., Wang, X., Wang, Z., Niu, W., Zhu, B., & Xia, G. (2013). Effect of different culture systems and 3, 5, 3'-triiodothyronine/follicle-stimulating hormone on preantral follicle development in mice. PLoS ONE, 8(4). https://doi.org/10.1371/journal.pone.0061947

14. Zhang, C., Niu, W., Wang, Z., Wang, X., & Xia, G. (2012). The effect of gonadotropin on glucose transport and apoptosis in rat ovary. PLoS ONE, 7(8). https://doi.org/10.1371/journal.pone.0042406