课题组以染色体易位所导致的白血病为疾病模型，主要利用蛋白质组学和功能基因组学方法研究遗传变异所导致的造血干细胞恶性转化为白血病的发病机制，探索发病过程中的转录成瘾机制以及鉴定全新的分子治疗靶标和靶向治疗策略。
1. 遗传变异和表观遗传变异所导致的血液肿瘤的发病机制和靶向治疗;
2. 转录成瘾机制和新靶标鉴定;
3. 基于转录成瘾机制的小分子靶向药物开发。
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