李枫 教授

职称职务：教授，博导，系主任

学科专业：医学遗传学

研究方向：肿瘤靶向治疗

实验室位置：基础医学院11号楼

Email： fli222@whu.edu.cn

学习经历

1998.09~2002.07 华中农业大学，攻读学士学位

2002.09~2008.01 华中农业大学&中国科学院生物物理研究所联合培养，硕博连读

主要工作经历与任职

2008.04~2013.04 University of Kentucky College of Medicine, 博士后

2013.06~至今 武汉大学医学遗传学系，教授、博导

目前主要科学研究领域和兴趣

目前研究方向为蛋白凝聚物调控肿瘤细胞稳态的机制研究，包括

1. 低流动性蛋白凝聚物的成分和功能解析

2. 基于肿瘤表观遗传的靶向治疗研究；

教学情况

先后主讲过《医学遗传学》（中文/英文）、细胞生物学、博士英语等。参编国家卫计委“十三五”规划教材《医学遗传学(英文)》(人民卫生出版社)。

代表性论文

1. Qian Zheng # , Pengfei Li # , Yulong Qiang # , Jiachen Fan , Yuzhu Xing , Ying Zhang, Fan Yang*, Feng Li*, Jie Xiong*,Targeting the transcription factor YY1 is synthetic lethal with loss of the histone demethylase KDM5C. EMBO Reports, (2024), Dec;25(12):5408-5428

2. Yurou Chen # ;Yulong Qaing # ;Jiachen Fan # ; Qian Zheng; Leilei Yan; Guanlan Fan; Xiaofei Song; Nan Zhang; Qiongying Lv; Jiaqiang Xiong; Jingtao Wang; Jing Cao; Yanyan Liu; Jie Xiong*; Wei,Zhang*; Feng Li*; Aggresome formation promotes ASK1/JNK signaling activation and stemness maintenance in ovarian cancer. Nature Communications, (2024), 15(1): 1321.

3. Yulong Qiang # ; Jiachen Fan # ; Chuanshuai Xie; Leilei Yan; Xiaofei Song; Nan Zhang; Yan Lin; Jie Xiong; Wei Zhang; Yu Liu; Lei Wei; Yu Li; Shizhen Chen; Kaiwei Liang; Feng Li*; KDM5C mediated recruitment of BRD4 to chromatin regulates enhancer activation and BET inhibitor sensitivity, Cancer Research, (2024). Apr 15;84 (8) :1252-1269.

4．Yan Lin, Mingkun Yang, Li Huang, Fan Yang, Jiachen Fan, Yulong Qiang, Yuting Chang, Wenjie Zhou, Leilei Yan, Jie Xiong, Jie Ping, Shizhen Chen, Dong Men* and Feng Li*. A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis (NASH) in mice via binding and relocating acetyl-coA carboxylase. Cell Reports, (2023), Nov 16; 42(11):113453.

5. Wenting Pan, Yihao Tian , Qian Zheng , Zelin Yang , Yulong Qiang , Zun Zhang , Nan Zhang , Jie Xiong* , Xin Zhu* , Lei Wei * and Feng Li *. Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation. Oncogene, (2023), Oct; 42(43):3194-3205.

6. Guanlan Fan^#, Fan Wang^#, Yurou Chen , Qian Zheng , Jie Xiong , Qiongying Lv , Kejia Wu , Jiaqiang Xiong , Lei Wei , Dongqing Li , Jiachen Zhang , Wei Zhang* and Feng Li* .The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region. Cell Reports, (2023), Jan 31; 42(1):111916.

7. Qian Zheng^#, Pengfei Li^#, Xin Zhou, Yulong Qiang, Jiachen Fan, Yan Lin, Yurou Chen, Jing Guo, Fan Wang, Haihua Xue, Jie Xiong* and Feng Li*. Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis. Theranostics , (2021) 11(18): 8674-8691.

8．Chen X^#, Zhao B^#, Qu Y, Chen Y, Xiong J, Feng Y, Men D, Huang Q, Liu Y, Yang B, Ding J and Feng Li*. Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019；Clinical Infectious Disease. (2020) 71(8):1937–42. 注: 该研究为SCI高被引论文。

9. 向莹,熊洁,李枫* 肿瘤细胞中染色质修饰与代谢的相互调控, 肿瘤代谢与营养电子杂志 , 2019年12月9日第6卷第4期.

10. Ying Xiang, Kai Yan, Qian Zheng, Haiqiang Ke, Jie Cheng, Wenjun Xiong, Xin Shi, Lei Wei, Min Zhao, Fei Yang, Ping Wang, Xing Lu, Li Fu, Xuemei Lu*, and Feng Li*.Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1. Cancer Research, (2019),79(1),86-98.

11. Xiaohua Chen, Loo JX, Shi X, Xiong W, Guo Y, Ke H, Yang M, Jiang Y, Xia S, Zhao M, Zhong S, He C, Fu L, and Feng Li*. E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the EGFR and c-MET Oncogenes by Destabilizing the Histone Demethylase KDM5C, Cancer Research, (2018),78(6),1418-1430.

12. Feng Li, J.Ortega, B.Peng, Gu, L., and Li,G.M*. Regulation of Mismatch Repair by Histone Code and Posttranslational Modifications in Eukaryotic Cells (Review). DNA Repair, (2016), 68–74.

13. Feng Li, Mao, G.G., Tong, D., Huang,J., Gu, L. *, and Li,G.M*, The histone mark H3K36me3 regulate human mismatch repair through its interaction with MutSalpha, Cell, 2013, 153, 590–600. 注: 该研究为SCI高被引论文。