熊海蓉 副教授

职称职务：副教授，博士/硕士研究生导师

学科专业：病原生物学

研究方向：病毒感染免疫与防治

实验室位置：基础医学院医学病毒学研究所2楼

Email：hrxiong@whu.edu.cn

学习经历

1997.9-2002.6 武汉大学医学院, 医学学士

2002.9-2009.6 武汉大学基础医学院, 病原生物学系,博士

2005.6-2009.3 Medical College of Georgia,联合培养博士

主要工作经历与任职

2009.7-2012.11 武汉大学基础医学院 讲师

2012.12-至今 武汉大学基础医学院 副教授

目前主要科学研究领域和兴趣

研究方向为病毒感染的致病机制与防治技术研究，主要包括：（1）病毒与宿主的相互作用及感染、致病机理（汉坦病毒、人类免疫缺陷病毒等）；（2）新发/再发病毒的基因组学；（3）抗病毒药物筛选及机制研究等。先后主持国家自然科学基金项目4项，多项教育部及省级基金项目。

教学情况

本科生课程：性传播疾病与青春期健康、实验室安全、组织与功能、细胞、分子与基因

研究生课程：高级医学病毒学、病原与宿主互作研究前沿、病原生物学实验技术、实验室生物安全

近五年主要代表性论文

1.Liu YY, Xu YQ, Zhong Y, Wei F, Ling JX, Li JL, Yang L, Quan FY, Chen SL, Luo F, Hou W, Yang ZQ, Chen LJ*, Xiong HR*. Pathogenicity of novel hantavirus isolate and antigenicity and immunogenicity of novel strain-based inactivated vaccine. Vaccine. 2023 Nov 30;41(49):7482-7490.

2.Yan J, Nie DH, Bai CS, Rehman A, Yang A, Mou XL, Zhang YQ, Xu YQ, Xiang QQ, Ren YT, Xu JL, Wang MR, Feng Y, Chen XP, Xiong Y, Hu HT, Xiong HR*, Hou W*. Fentanyl enhances HIV infection in vitro. Virology. 2022 Oct 11;577:43-50.

3. Wang X, Chen QZ, Zan YX, Wang MR, Yan J, Guo WW, Li KJ, Liu YY, Luo F, Feng Y, Hou W*, Xiong HR*. Exosomal miR-145-5p derived from orthohantavirus-infected endothelial cells inhibits HTNV infection. FASEB Journal. 2020 Oct;34(10):13809-13825.

4. Wang MR, Wu DD, Luo F, Zhong CJ, Wang X, Zhu N, Wu YJ, Hu HT, Feng Y, Wang X, Xiong HR*, Hou W*. Methadone inhibits viral restriction factors and facilitates HIV infection in macrophages. Frontiers in Immunology. 2020 Jul 3;11:1253.

5. Chen QZ, Wang X, Luo F, Li N, Zhu N, Lu S, Zan YX, Zhong CJ, Wang MR, Hu HT, Zhang YZ, Xiong HR*,Hou W*. HTNV sensitizes host toward TRAIL-mediated apoptosis — a pivotal anti-hantaviral role of TRAIL. Frontiers in Immunology. 2020 Jun 19;11:1072.

6. Shen MX, Ma N, Li MK, Liu YY, Chen T, Wei F, Liu DY, Hou W, Xiong HR*, Yang ZQ*. Antiviral Properties of R. tanguticum Nanoparticles on Herpes Simplex Virus Type I In Vitro and In Vivo. Frontiers in Pharmacology. 2019 Sep 4;10:959.

7. Li MK, Liu YY, Wei F, Shen MX, Zhong Y, Li S, Chen LJ, Ma N, Liu BY, Mao YD, Li N, Hou W, Xiong HR*, Yang ZQ*. Antiviral activity of arbidol hydrochloride against herpes simplex virus type in vitro and in vivo. International Journal of Antimicrobial Agents. 2018 Jan;51(1):98-106

8. Chen QZ, Luo F, Lu MX, Li N, Teng Y, Huang QL, Zhu N, Wang GY, Yue M, Zhang Y, Feng Y, Xiong HR*, Hou W*. HTNV-induced upregulation of miR-146a in HUVECs promotes viral infection by modulating pro-inflammatory cytokine release. Biochemical and Biophysical Research Communications. 2017 Nov 4;493(1):807-813.

9. Chen XP^§, Xiong HR^§, Zhu N, Chen QZ, Wang H, Zhong CJ, Wang MR, Lu S, Luo F, Hou W*. Lack of association between integrin αvβ3 gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. Virologica Sinica. 2017 Feb;32(1):73-79.

10. Liu YY, Chen LJ, Zhong Y, Shen MX, Ma N, Liu BY, Luo F, Hou W, Yang ZQ, Xiong HR*. Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo. Acta Pharmacologica Sinica. 2016 Apr;37(4):497-504