Jing Yang, M.D., PH.D,
E-mail Address: yangjingliu2013@163.com
Office Address: 185# DongHu Road, Wuhan, Hubei, 430071
Position(s): Professor
Affiliation(s):Department of Pharmacology
Research interests / Specialties:
Research and development of new drug, Pharmacology and toxicology of antitumor drugs
Education and Training
Medical Degree., 1982-1987 Hubei Medical University, China
M.S., 1987-1990 Hubei Medical University, China
Ph.D.,1998-2001 Wuhan University, China
Exchange and Training, 2006 Fukushima Medical University, Japan
Research Description
The focus of the lab was the key lipid metabolites of cell membrane which mediate tumor growth, angiogenesis and metastasis. Arachidonic acid (AA) is liberated from the cellular membranes by cytoplasmic phospholipase A2 (PLA2), and furthermetabolized through cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP) pathways to eicosanoids. These lipids which are abundantly produced by various tumors, regulate cell growth, survival and invasion. The dual inhibitors targeting COX-2, LOX and CYP4A/F have the potential to increase efficacy, selectively and potentially overcome some side effects due to single inhibition. Our findings could lead to a novel multi-target therapeutic approach in human tumors.
Flavonoids exert extensive in vitro and in vivo anti-tumor activities. We have also investigated the molecular mechanisms by which active ingredients of traditional Chinese herbs, including flavonoids, inhibits tumor growth, angiogenesis and metastasis. We have demonstrated that isoliquiritigenin, a flavonoid from licorice, inhibits human breast cancer metastasis by preventing anoikis-resistance, migration and invasion through downregulating COX-2 and cytochrome CYP 4A signaling. It suggests that isoliquiritigenin could be a promising multi-target agent for preventing breast cancer metastasis, and anoikis could represent a novel mechanism through which flavonoids may exert the anti-metastatic activities.
Publication list
1. Chen L, Ackerman R, Saleh M, Gotlinger KH, Kessler M, Mendelowitz LG, Falck JR, Arbab AS, Scicli AG, Schwartzman ML, Yang J*, Guo AM*. 20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo. J Pharmacol Exp Ther. 348 (3): 442-51, 2014.
2. Zhao H, Zhang X, Chen X, Li Y, Ke Z, Tang T, Chai H, Guo AM, Chen H, Yang J*. Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. Toxicol Appl Pharmacol. 12; 279(3):311-321, 2014.
3. Zheng H, Li Y, Wang Y, Zhao H, Zhang J, Chai H, Tang T, Yue J, Guo AM, Yang J*. Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. Toxicol Appl Pharmacol. 2; 280(1):10-20, 2014.
4. Bing Y, Zhu S, Jiang K, Dong G, Li J, Yang Z, Yang J, Yue J*. Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke. Biochem Pharmacol. 87 (4):636-49, 2014.
5. Li Y, Zhao H, Wang Y, Zheng H, Yu W, Chai H, Zhang J, Falck JR, Guo AM, Yue J, Peng R, Yang J*. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicol Appl Pharmacol. 272 (1), 37-48, 2013.
6. Yu W, Chai H, Li Y, Zhao H, Xie X, Zheng H, Wang C, Wang X, Yang G, Cai X, Falck JR, Yang J*. Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer. Toxicol Appl Pharmacol. 264 (1), 73-83, 2012.
7. Zhao H, Li Y, Wang Y, Zhang J, Ouyang X, Peng R, Yang J*. Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice. Food Chem Toxicol. 50 (8), 2648-55, 2012.
8. Shi Y, Wu D, Sun Z, Yang J, Chai H*, Tang L, Guo Y. Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. Phytother Res. 26 (9):1410-7, 2012.
9. Xiao-Yan Zhang, Wei Zhou, Yong Xu, Yu-Xi Zhang, Jing Yang*, Geng-Li Duan*. LC–ESI/MS analysis of levodopa and methyldopa (IS) in beagle dog pharmacokinetic study after oral administration and domperidone given in advance. J. Chin. Chem. Soc. 59, 710-717, 2012.
10. Li H*, Yan Z, Zhu J, Yang J, He J. Neuroprotective effects of resveratrol on ischemic injury mediated by improving brain energy metabolism and alleviating oxidative stress in rats. Neuropharmacology. 60 (2-3):252-8, 2011.
11. Yu W, Chen L, Yang YQ, Falck JR, Guo AM, Li Y, Yang J*. Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer. Cancer Chemother Pharmacol. 68 (3), 619-629, 2011.
12. Xiong Y, Yang Y, Yang J, Chai H*, Li Y, Yang J, Jia Z, Wang Z. Tectoridin, an isoflavone glycoside from the flower of Pueraria lobata, prevents acute ethanol-induced liver steatosis in mice. Toxicology. 2010; 276(1): 64-72.
