Yueshan Lei, MD, PhD

E-mail Address: lysh9638@whu.edu.cn

Office Address: 185# DongHu Road, Wuhan,

Hubei, 430071

Position(s):

Associate Professor

Affiliation(s):

Department of Anatomy

Research interests / Specialties:

Mechanism of estrogen on vascular smooth muscle

Education and Training:

B.S., 1987-1992 Hubei Medical University, China

M.S., 1998-2002 WuHan University School of Medicine, China

Ph.D., 2004-2013 WuHan University School of Medicine, China

Research Description

My research is about some roles of p53 in cell senescence, autophagy and cell apoptosis. Our research reveals: During senescence, p53 is not only involved in the regulation of cell senescence but its function are also associated with cell autophagy. P53 may combine with RASSF1A promoter specifically and reduced the expression level of RASSF1A. p53 had controlled the range of cell apoptosis probably by this action of RASSF1A, and prevented excessive apoptosis from increasing the damage to the organization. This make the body dealing with the bad environmental stimuli and make cell to establishing an appropriate balance between survival and death.

Publication list:

1. Yueshan Lei, Chengjun Hu, Hongxin Xu Yihao Tian.. HPV16 infection regulates RASSF1A transcription mediated by p53. MOLECULAR MEDICINE REPORTS. 2013; 8(2): 413-418

2. Zheng, Y: Hu CJ: Zhuo RH: Lei YS: Han NN: He L. Inhibition of autophagy alleviates the senescent state of rat mesenchymal stem cells during long-term culture. MOLECULAR MEDICINE REPORTS. 2014; 10(6): 3003-3008

3. Bei Cheng, Jian Song, Yun Zou, Qiao Wang, Yueshan Lei,Congli Zhu, Chengjun Hu. Responses of vascular smooth muscle cells to estrogen are dependent on balance between ERK and p38 MAPK pathway activities. International Journal of Cardiology . 2009 ;134: 356–365