Zongwen Tian, PH.D
E-mail Address: tianzwen@hotmail.com
Office Address: 185# DongHu Road, Wuhan, Hubei, 430071
Position(s): Associate Professor
Affiliation(s):Department of Anatomy
Research interests / Specialties:
Protein quality control、degradation and its molecular mechanisms in various heart diseases.
Education and Training
B.S. 1979-1984 Hubei University of Science and Technology, China
M.S. 1988-1991 Wuhan University School of Medicine , China
Ph.D. 2001-2006 Wuhan University School of Medicine , China
Post-doctoral training, 2009-2012 University of South Dakota, U.S.A
Research Description
My research mainly investigates the protein quality control、degradation and its molecular mechanisms in various heart diseases. For example, genetically induced inhibition of the proteasome in cardiomyocytes exacerbates myocardial ischemia-reperfusion injurl.
I have also begun to determine the effects of PSM-β5 activity on cardiac stem cells (CSCs) migration, proliferation and differentiation in T60A-PSM-β5 transgenic mice after myocardial infarction, and explore the possible mechanisms.
Publication list
1. SUN Xiao-Dong，WANG Yan，WANG Han-Qin，SANG Ming，TIAN Zong-Wen ( Corresponding author). p38MAPK Mediates PDGF-BB-induced MMP-2 Expression in Rat Vascular Smooth Muscle Cells. Chin J Arterioscler. 2014, Vol 22, No 4: 340-344.
2. Tian,Z，Wang C，Hu C, Liu J，Wang X. Autophagic-Lysosomal Inhibition Impairs Cardiac Ubiquitin-Proteasome System Performance in a p62-Dependent Manner. PLOS ONE. 2014 Jun 24;9(6):e100715.
3. Tian Z, Zheng H, Li J, Li Y, Su H, Wang X. Genetically induced moderate inhibition of the proteasome in cardiomyocytes exacerbates myocardial ischemia-reperfusion injury in mice. Circ Res. 2012 Aug 17;111(5):532-42.
4. Zheng Q, Su H, Tian Z, Wang X..Proteasome malfunction activates macroautophagy in the heart.. Am J Cardiovasc Dis.2011;1(3):214-26. Epub 2011 Jul 28.
5. Lei D, Li F, Su H, Tian Z, Ye B, Wei N, Wang X..COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation Cell Death Differ. 2011 Feb;18(2):259-70. Epub 2010 Aug 6.
Zheng H, Tang M, Zheng Q, Kumarapeli AR, Horak KM, Tian Z, Wang X. Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy. J Am Coll Cardiol. 2010 Oct 19;56(17):1418-26.
