Jiang YUE, M.D., PH.D
E-mail Address: yuejiang@whu.edu.cn
Office Address: 185# DongHu Road, Wuhan, Hubei, 430071
Position(s): Professor
Affiliation(s):Department of Pharmacology
Research interests / Specialties:
Drug-metabolizing enzymes and nuclear receptor
Education and Training
Medical Degree in Psychiatry, 1993-1998, Wuhan University, Wuhan, P.R.China
Ph.D. in Medicine, 1999-2004, Wuhan University, Wuhan, P.R.China
Post-doctoral training, 2005-2008, University of Toronto, Canada
Visiting scholar, 2015-2016, National Institutes of Health, U.S.A.
Research Description
The cytochromes P450 (CYP) enzymes are present in the central nervous system with unique regional and cell-type expression. Our recent studies have shown that brain CYPs be organ-selectively regulated by endogenous substances via brain-enriched microRNAs. Brain CYPs are in situ involved in the metabolism of exogenous and endogenous centrally active substances (e.g. drugs, neurotoxins, neurotransmitters). We are interested in the roles of brain CYPs in neuropharmacology and neurotoxicity. The elucidation of the pharmacological roles of brain CYPs will be useful to understand the pathology of the damage to neuronal cells by exogenous substance, and provide the clue for the development of the potential diagnostic biomarkers and therapeutic drugs. We investigate the function and regulation of brain CYPs, integrating the fields of pharmacokinetics in biophase and signal pathways, using in vitro and animal studies. Our experimental approach principally involves biochemical, protein and molecular biological techniques as well as analytical chemistry techniques.
Publication list
1. Jie Li, Mengmeng Xie, Xiaoshuang Wang, Xiufang Ouyang, Yu Wan, Guicheng Dong, Zheqiong Yang, Jing Yang, Jiang Yue*. Sex hormones regulate cerebral drug metabolism via brain miRNAs: down-regulation of brain CYP2D by androgens reduces the analgesic effects of tramadol. British Journal of Pharmacology 2015; DOI: 10.1111/bph.13206
2. Jie Li; Yu Wan; Shufang Na; Xiaochan Liu ; Guicheng Dong; Zheqiong Yang; Jing Yang; Jiang Yue*. Sex-dependent regulation of hepatic CYP3A by growth hormone: Roles of HNF6, C/EBPα, and RXRα. Biochemical Pharmacology 2015; 93: 92-103.
3. Qiaoli Wang, Xiaotong Han, Jian Li, Xinghui Gao, Yan Wang, Mingzhou Liu, Guicheng Dong, Jiang Yue*. Regulation of cerebral CYP2D alters tramadol metabolism in the brain: interactions of tramadol with propranolol and nicotine. Xenobiotica 2014; DOI: 10.3109/00498254.2014.981609.
4. Yuntao Bing, Siying Zhu, Kun Jiang, Guicheng Dong, Jie Li, Zheqiong Yang, Jing Yang, Jiang Yue*. Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke. Biochemical Pharmacology 2014; 87: 636-649.
5. Xiaoshuang Wang, Jie Li, Guicheng Dong, Jiang Yue*. The endogenous substrates of brain CYP2D. European Journal of Pharmacology 2014; 724: 211-218.
6. Yanjun Zhong, Guicheng Dong, Haiguang Luo, Jie Cao, Chang Wang, Jianyuan Wu, Yu-Qi Feng, Jiang Yue*. Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem. Toxicology 2012(302): 275-284. http://dx.doi.org/10.1016/j.tox.2012.08.009
7. Jiang Yue, Guicheng Dong, Chunyan He, Jie Chen, Yinghui Liu, Renxiu Peng. Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats. Toxicology 2009; 264: 185-91.
8. Jiang Yue*, Renxiu Peng. Does CYP2E1 play a major role in the aggravation of isoniazid toxicity by rifampicin in human hepatocytes? British Journal of Pharmacology 2009; 157: 331-333. Epub 2009Apr 9
9. Jiang Yue#, Jibran Khokhar#, Sharon Miksys, Rachel F. Tyndale. Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. European Journal of Pharmacology 2009; 609(1-3): 88-95. Epub 2009 Mar 13.
10. Jiang Yue, Renxiu Peng, Jie Chen, Yinghui Liu, Guicheng Dong. Effects of rifampin on CYP2E1-dependent hepatotoxicity of isoniazid in rats. Pharmacological Research 2009; 59(2): 112-9. Epub 2008 Nov 1
11. Jiang Yue, Sharon Miksys, Ewa Hoffmann, Rachel F. Tyndale. Chronic nicotine treatment induces rat CYP2D in brain but not in liver: an investigation of induction and time course. Journal of Psychiatry & Neuroscience 2008; 33(1): 54-63.
12. Yue Jiang, Wang Peng, Liu Yinghui, Wu Junyu, Chen Jie, Peng Renxiu. Fast evaluation of oxidative DNA damage by liquid chromatography-electrospray tandem mass spectrometry coupled with precision-cut rat liver slices. Biomedical and Environmental Sciences 2007; 20: 387-91.
13. YUE Jiang, PENG Ren-Xiu, YANG Jing, et al. CYP2E1 mediated isoniazid-induced hepatotoxicity in rats. Acta Pharmacol Sin 2004; 25(5): 699-704.
14. Siying Li, Baoping Yu, Jiang Yue*. The Application of Case-oriented Self-learning and Review in Pharmacology Teaching. The American Journal of the Medical Sciences 2014; 348(1): 52-6.
