Yihao Tian, PH.D
E-mail Address: yihaotian@whu.edu.cn
Office Address: 185# DongHu Road, Wuhan, Hubei, 430071
Position(s): Lecturer
Affiliation(s):Department of Anatomy
Research interests / Specialties:
Transcriptional regulation and Protein
Quality Control and Degradation
Education and Training
B.S., 1993-1998 Wuhan University School of Medicine, China
Ph.D., 2003-2009 Wuhan University College of Life Sciences, China
Post-doctoral training, 2012-2014 University of South Dakota, U.S.A
Research Description
I major in the molecular mechanisms of transcriptional regulation and protein quality control and degradation. Oncogenes and tumor suppressors work in concert to regulate cell growth or death, which is a pair of antagonist factors for regulation of tumorigenesis. We showed promoter characteristic of tumor suppressor RASSF1A, which revealed a p53 binding site in the distal and a GC-rich region in the proximal promoter region of RASSF1A. We demonstrated that p53 protein specifically binds to the RASSF1A promoter and inhibits its expression.
I also begin to explore the mechanism of protein quality control and degradation in heart diseases. We found that ubiquitin receptor Ubiquilin1 (Ubqln1) play an important role in the occurrence and development of heart failure.
Publication list
1. Lei Y, Hu C, Xu H, Tian Y*. HPV16 infection regulates RASSF1A transcription mediated by p53. Mol Med Rep. 2013, 8(2):413-8.
2. Tian Y, Hou Y, Zhou X, Cheng H, Zhou R. Tumor suppressor RASSF1A promoter: p53 binding and methylation. PLoS One. 2011, 6(2):e17017.
3. Su K, Tian Y（Co-first）, Wang J, Shi W, Luo D, Liu J, Tong Z, Wu J, Zhang J, Wei L. HIF-1α acts downstream of TNF-α to inhibit vasodilator-stimulated phosphoprotein expression and modulates the adhesion and proliferation of breast cancer cells. DNA Cell Biol. 2012, 31(6):1078-87.
4. Tang M, Tian Y（Co-first）, Li D, Lv J, Li Q, Kuang C, Hu P, Wang Y, Wang J, Su K, Wei L. TNF-α mediated increase of HIF-1α inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI). PLoS One. 2014, 9(7):e102967.
5. An P, Tian Y（Co-first）, Chen M, Luo H. Ca (2+) /calmodulin- dependent protein kinase II mediates transforming growth factor-β-induced hepatic stellate cells proliferation but not in collagen α1 (I) production. Hepatol Res. 2012, 42(8):806-18.
