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Guohua Yang, PH.D


E-mail Address:

Office Address: 185# DongHu Road, Wuhan, Hubei, 430071


Associate Professor


Department of Medical Genetics

Research interests / Specialties:

Identification and functional characterization of human disease genes

Education and Training

B.S., 1992—1995 Department of Biology, Xiaogan Normal college

Ph.D., 2001—2006 College of Life Sciences, Wuhan University

Visiting research, 2014 — 2015 Cleveland Clinic Foundation, Ohio, US

Research Description

My research focuses on the molecular diagnosis of human genetic disease. Our interest is in translating knowledge obtained from basic research studies to the diagnostic arena, and in developing tools and implementing new technology to improve the diagnosis of human genetic disease. Another area of interest is gene methylation analysis and its implication in diagnostics.

1. Haplotype analysis on Chromosome X for a DMD family


2. GJB2 DNA sequence alignment of a non-syndromic deafness family


Publication list

1. Li C, Wang L, Zhang J, Huang M, Wong F, Liu X, Liu F, Cui X, Yang G, Chen J, Liu Y, Wang J, Liao S, Gao M, Hu X, Shu X, Wang Q, Yin Z, Tang Z, Liu M. CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochim Biophys Acta. 2014; 1842(7): 1121-9.

2. Xiaohua Chen, Xiaoyan Yu, Jie Zhou, Wei Jiang, Jun Hu, Shan Zhong, Guohua Yang. Mutation analysis of GJB2 gene and prenatal diagnosis in a non-syndromic deafness family. 2014, Med J Chin PLA, 39(7): 557-561.

3. Changyong Li, Guohua Yang, Jie Ruan, Sphingosine kinase 1/sphingosine-1- phosphate receptor type 1signalling axis is induced by transforming growth factor-β1 and stimulates cell migration in RAW264.7 macrophages, Biochemical and Biophysical Research Communications. 2012; 426(3): 415-420.

4. Risheng Liang, Xiaolei Zhuo, Guohua Yang, Daji Luo, Shan Zhong, Jixing Zou. Molecular phylogenetic relationships of family Haemulidae and the related species based on mitochondrial and nuclear genes. Mitochondrial DNA. 2012, 23(4):264-77.

5. Juan Tian, Guohua Yang, Songshan Wang, Yuanzhen Zhang, Guibo Song, Fang Zheng. Molecular diagnosis of two families with classic congenital adrenal hyperplasia. Gene. 2011, 482(1-2): 8-14.

6. Guohua Yang, Shan Zhong, Xianrong Zhang, Biwen Peng, Jun Li, Tie Ke, Hua Xu. Molecular Genetic Analysis of Autosomal Dominant Late-Onset Cataract in a Chinese Family. J Huazhong Univ Sci Technol. 2010, 30(6):792-6.

7. Yukan Huang, Jing Zhang, Chang Li, GuohuaYang, Mugen Liu, Qing Wang, Zhaohui Tang. Identification of a novel homozygous nonsense mutation in EYS in a Chinese family with autosomal recessive retinitis pigmentosa. BMC Med Genet. 2010, 11: 121-6.

8. Guohua Yang, Lei Wang, Yuyan Gong, Zhihou Liang, Xiang Ren. Prenatal gene diagnosis for the Duchenne muscular dystrophy risk fetus by molecule markers. Medical Journal of Wuhan University. 2009, 30 (6):443-6.

9. Kun Wang, Ya Gao, Xiaojue Peng, Guohua Yang, Feng Gao, Shaoqing Li, Yingguo Zhu. Using FAM labeled DNA oligos to do RNA electrophoretic mobility shift assay. Mol Biol Rep. 2010, 37(6):2871-5.