Yu Wan, Ph.D.

E-mail: wanyu@whu.edu.cn

Office Address: Building No.1, DongHu Road 185#, Wuhan, Hubei, 430071

Position: Professor, Director of Department of Physiology

Affiliation: Department of Physiology, Wuhan University

Research interests: The relationship of endocrine factors and diseases

Education and Training

Ph.D., 2000~2003, University of Queensland, Australia.

Ms.D, 1984~1987, Henan Medical University, China.

B.S., 1975~1978, Xiangya Medical College, China.

Research Description:

My laboratory focuses on studying the relationship between endocrine factors (such as GH/IGF-1, E2 and VEGF) and the development of central nerve system, Cardiovascular disease and cancers. Our research has been funded by multiple grants from National Natural Science Foundation of China, State Natural Science Foundation and State Health Department. I have been authored/coauthored more than 50 peer-reviewed papers in national and international journals including Journal of Neurochemistry, Journal of Biological Chemistry, Molecular Endocrinology and Nature: Struct Mol Biol. More than 20 master 's and doctoral students have studied in my laboratory during past decade.

Publication list (* Corresponding author)

1. Wu Y , Shen Y, Kang K , Zhang YH , Ao F , Wan Y *, Song J*, Effects of estrogen on growth and smooth muscle differentiation of vascular wall-resident CD34t stem/progenitor cells, Atherosclerosis, 240:453~ 461,2015

2. Tang JM*, Luo B, Xiao JH, Lv YX , Li XL, Zhao JH, Zheng F, Zhang L, Wan Y* , VEGF-A promotes cardiac stem cell engraftment and myocardial repair in the infarcted heart. International Journal of Cardiology,183: 221–231, 2015.

3. Liu Y, Zhao Z, Gao YM, Yang F and Wan Y*, MiRNA-181a is involved in IGF-1 mediated regulation of CREB1 expression in Hippocampus, Journal of Neurochemistry, 126(6): 771 - 80, 2013.

4. Liu Y, Wu T, Song J, Chen XL, Zhang Y, and Wan Y*, A mutant screening method by critical annealing temperature-PCR for site-directed mutagenesis, BMC Biotechnology, 13:21, 1-8, 2013

5. Tang HQ; Yu XM; Song J; Xu CS; Wan Y*. Changes in Growth Hormone (GH), GH Receptor and GH Signal Transduction in Hippocampus of Congenital Hypothyroid Rats. J Neurosci Res, 89:248–255，2011.

6. Jiang j#, Wan Y#, Wang XD#, Xu J, Harris JM, Lobie PE, Zhang Y, Zinn KR, DVM, Waters MJ, Frank SJ. Inhibitory GH Receptor Extracellular Domain Monoclonal Antibodies: Three-dimensional Epitope Mapping. Endocrinology, 152: 3777-3788, 2011.

7. Wu ZS, Yang K, Wan Y, Qian PX, Perry JK, Chiesa J, Mertani HC, Zhu T and Lobie PE Expression of Human GH and Human Prolactin Predict a Worse Survival Outcome in Patients with Mammary or Endometrial Carcinoma, J Clin Endocrin Metab，17,1235-1245, 2011.

8. Sherer R*, Wan Y, Dong HM, Cooper B, Morgan I, Peng BW, Liu J, Wang L, and Xu D, Positive impact of integrating histology and physiology teaching at a medical school in China, Adv Physiol Educ 38: 330–338, 2014;

9. He L, Zheng Y, Wan Y, Song J*, A shorter telomere is the key factor in preventing cultured human mesenchymal stem cells from senescence escape, Histochem Cell Biol, DOI 10.1007/s00418-014-1210-5, 2014

10. Yu Y, Li JX, Wan Y , Lu JY, Gao JM, Huang CS*, GADD45a Induction by Nickel Negatively Regulates JNKs/p38 Activation via Promoting PP2Ca Expression, PLOS ONE, 8:3( e57185) 1-9, 2013

11. Zheng Y, He L, Wan Y, Song J*. H3K9me-Enhanced DNA Hypermethylation of the p16(INK4a) Gene: An Epigenetic Signature for Spontaneous Transformation of Rat Mesenchymal, Stem Cells Dev. 15;22(2):256-67, 2013.

12. Tang J, Wang J, Kong X, Yang J, Guo L, Zheng F, Zhang L, Huang Y, Wan Y*. Vascular endothelial growth factor promotes cardiac stem cell migration via the PI3K/Akt pathway. Exp Cell Res. 315:3521–3531, 2009.

13. Yu YH, Wan Y*, and Huang CS*, The Biological Functions of NF-κB1 (p50) and its Potential as an Anti-Cancer Target，Current Cancer Drug Targets, Curr Cancer Drug Targets. 9(4):566-71, 2009.

14. Brown RJ#, Adams JJ#, Pelekanos RA#, Wan Y, McKinstry WJ, Palethorpe K, Seeber RM, Monks TA, Karin A. Eidne KA, Parker MW, Waters MJ. A Model for Growth Hormone receptor Activation Based on Subunit rotation within a Constitutive Dimer. Nature: Struct Mol Biol. 12 (9):814-21. 2005.

15. Wan Y, McDevitt A, Shen B, Smythe ML, Waters MJ. Increased Site 1 affinity improves biopotency of porcine growth hormone: Evidence against diffusion dependent receptor dimerization. J. Biol. Chem. 279 (43): 44775-44784. 2004.

16. Wan Y, Zheng YZ, Harris JM, Brown RJ, and Waters MJ. Epitope Map for A Growth Hormone Receptor Agonist Monoclonal Antibody, Mab 263. Molecular Endocrinology. 17 (11): 2240-2250，2003.