Xiaolian Zhang, PH.D

E-mail Address: zhangxiaolian@whu.edu.cn

Office Address: 185# DongHu Road, Wuhan, Hubei, 430071

Position(s): professor

Affiliation(s): Department of Immunology

Research interests / Specialties: molecular Immunology and glycoimmunology

Education and Training

1982-1986 B.M. Wuhan University, Wuhan, China

People’s Republic of China.

1986-1989 M.S. Wuhan University, Wuhan, China

People’s Republic of China.

1993-1997 Ph.D. Hongkong University of Science and Technology, Hongkong

1997-2001 Postdoc. Univ. of Maryland, College Park, MD, USA

Research Description

She has long been focused on the molecular immunology and infection immunology of intracellular pathogens. She first discovered type IV cilia gene operon and site-specific recombination enzyme gene on Salmonella typhi pathogen virulence island, and elucidated the specific pathogenesis mechanism of the typhoid bacillus IV cilia on human cells, not to mention a series of other internationally advanced research achievements. For achievements in pathogenic microorganisms glycoimmunology and infection immunology, she was awarded the Hubei Province Natural Science Award the first prize and the second prize, Chinese Medical Science and Technology Award the second prize. She got 28 authorized invention patents, and published more than 110 papers, including more than 80 SCI papers, which were cited by Nature, Nature Reviews Microbiology, etc. for more than 1000 times, with one paper cited 88 times and recommended by the Faculty of 1000 as Top 2%. She served as the chief editor for 5 textbooks such as "Virus Immunology" (Science Press, China), "Infectious Immunology" and "Medical Immunology" (the People's Health Press, China), as well as deputy editor for 6 textbooks. She was invited make special lectures by 10 International conferences, and presided over/take part in nearly 20 national, provincial, or ministerial level science projects, including the National Major Infectious Disease Special Project, 973 Project (2), National Natural Science Foundation Outstanding Youth Fund, one major Project and six general projects.

Publication list

1. Zhao Y, Ren Y, Zhang X, Zhao P, Tao W, Zhong J, Li Q, Zhang XL*. Ficolin-2 inhibits Hepatitis C Virus infection, whereas apolipoprotein E3 mediates viral immune escape. J Immunol.2014, 193(2):783-96 , cited by F1000Prime

2. Pan Q, Wang Q, Sun X, Xia X, Wu S, Luo F, Zhang XL*. Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys. Mol Ther. 2014, 22(5):940-51.

3. Tang XL, Zhou YX, Wu SM, Pan Q, Xia B, Zhang XL*. CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents. J Infect. 2014, 69: 569-580.

4. Wu SM, Ai HW, Zhang DY, Han XQ, Pan Q, Luo FL, Zhang XL*. miR-141 targets ZEB2 to suppress HCC progression. Tumour Biol. 2014, 35(10):9993-7.

5. Luo F, Sun X, Wang Y, Wang Q, Wu Y, Pan Q, Fang C, Zhang XL*. Ficolin-2 defends against virulent Mycobacteria Tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PloS One, 2013, 8 (9): e73859.

6. Yilan Hu, Fengling Luo, Junliang Fu, Tielong Chen, Shimin Wu, Yi-Dan Zhou, Xiao-Lian Zhang*. Early increased ficolin-2 concentrations are associated with severity of liver inflammation and efficacy of anti-viral therapy in chronic hepatitis C patients. Scand J Immunol 2013,77:144-150.

7. Pan Q, Chen H, Wang F , Jeza VT , Hou W, Zhao Y, Xiang T, Zhu Y, Endo Y, Fujita T, Zhang XL*L-ficolin binds to glycoproteins HA and NA and inhibits influenza A virus infection both in vitro and in vivo. J Innate Immun 2012. 4:312-24.

8. Chen HD, Zhou X, Yu G, Zhao YL, Ren Y, Zhou YD, Li Q, Zhang XL*. Knockdown of core 1 beta 1, 3-galactosyltransferase prolongs skin allograft survival with induction of galectin-1 secretion and suppression of CD8+T cells. J Clin Immunol 2012, 32:820-836.

9. Deng M, Feng S, Luo F, Wang S, Sun X, Zhou X*, Zhang XL*. Visual detection of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis using an asymmetrically split peroxidase DNAzyme. J. Clin. Microbiol. 2012.50: 3443-3450

10. Ma Y, Chen Hai-Dan, Wang Yubin, Wang Qilong, Li Yingying, Zhao Yinglan, Zhang Xiao-lian*. Interleukin 24 as a novel potential cytokine immunotherapy for the treatment of Mycobacterium tuberculosis infection. Microbes Infect. 2011, 13: 1099-1110.

11. Chen F, Zhao Y, Liu M, Li D, Wu H, Chen H, Zhu Y, Zhong J, Zhou Y, Qi Z, Zhang XL*. Functional Selection of Hepatitis C Virus Envelope E2 Binding Peptide Ligand Using Ribosome Display. Antimicrob Agents Chemother. 2010, 54: 3355-3364. cited by FACULTYof1000

12. Zhong B, Zhang L, Lei C, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB*.The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity 2009, 30(3):397-407.

13. Ma Y, Chen H, Wang Q, Luo F, Yan J, Zhang XL* IL-24 protects against Salmonella typhimurium infection by stimulating early neutrophil Th1 cytokine production that in turn activate CD8+ T cells. Eur J Immunol 2009, 39:3357-68.

14. Chen F, Hu Y, Li D, Chen H, and Zhang XL*. CS-SELEX generates high-affinity ssDNA aptamers as molecular probes for Hepatitis C Virus envelope glycoprotein E2. PloS One, 2009, 4 (12):e8142:1-11.

15. Li DQ, Li Y, Wu X, Li Q, Yu J, Gen J, Zhang XL*. Knockdown of Mgat5 inhibits breast cancer cell growth with activation of CD4+T cells and macrophages. J Immunol 2008, 80: 3158-3165.