Dongcheng Wu, M.D., Ph.D.
E-mail Address: bcdcwu@hotmail.com
Office Address: Building No.2, DongHu Road 185#, Wuhan, Hubei, 430071
Position: Professor
Affiliation:Department of Biochemistry and Molecular Biology
Research interests / Specialties: The molecular mechanisms of glomerulosclerosis in diabetic ephropathy, the role of autologous bone marrow–derived mesenchymal stem cell transplantation for the treatment of acute kidney injury and its molecular mechanism.
Education and Training
Medical Degree, 1982-1987 Hubei Medical College, Wuhan, China
M.Sc ., 1990-1993 Hubei Medical University, Wuhan, China
1998-2000 Hong Kong University of Science and Technology, Hong Kong, China
Ph. D.,2002-2005 Wuhan University, Wuhan, China
Post-doctoral training, McMaster University, Canada
Research Description
1. Study the molecular mechanisms of glomerulosclerosis in diabetic nephropathy.
2. Study the role of autologous bone marrow–derived mesenchymal stem cell transplantation for the treatment of acute kidney injury and its molecular mechanism.
Publication list
1. Qi S, Wu D. Bone marrow-derived mesenchymal stem cells protect against cisplatin-induced acute kidney injury in rats by inhibiting cell apoptosis. Int J Mol Med 2013, 32(6):1262-1272.
2. Jiang PC, Xiong WP, Wang G, Ma C, Yao WQ, Kendell SF, Mehling BM, Yuan XH, Wu DC. A clinical trial report of autologous bone marrow-derived mesenchymal stem cell transplantation in patients with spinal cord injury. Exp Ther Med 2013, 6(1):140-146.
3. Du H, Yao W, Fang M, Wu D. ARF triggers cell G1 arrest by a P53 independent ERK pathway. Mol Cell Biochem 2011, 357(1-2):415-422.
4. Wu D, Peng F, Zhang B, Ingram AJ, Gao B and Krepinsky JC. PKCβ1 mediates high glucose-induced Akt activation and TGFβ1 upregulation in kidney mesangial cells. J Am Soc Nephrol 2009, 20(3):554-566.
5. Peng F, Wu D, Gao B, Ingram AJ, Zhang B, Chorneyko K, McKenzie R, Krepinsky JC. RhoA/Rho-kinase Contribute to the Pathogenesis of Diabetic Renal Disease. Diabetes 2008, 57(6):1683-1692.
6. Peng F, Zhang B, Wu D, Ingram AJ, Gao B, Krepinsky JC. TGFbeta-induced RhoA activation and fibronectin production in mesangial cells require caveolae. Am J Physiol RenalPhysiol 2008, 295(1):F153-164.
7. Zhang B, Peng F, Wu D, Ingram AJ, Gao B, Krepinsky JC. Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells. Cellular Signaling 2007, 19(8):1690-1700.
8. Wu D, Peng F, Zhang B, Ingram AL, Gao B, Krepinsky JC. Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells. Diabetologia 2007, 50(9):2008-2018.
9. F Peng，Wu D, Ingram AJ， Krepinsky JC,. Stretch-Induced RhoA Activation is Dependent on Caveolae in Mesangial Cells. J Am Soc Nephrol 2007, 18(1):189-198.
10. Wu D, Chen B, Parihar K, He L, Fan C, Zhang J, Liu L, Gillis A, Bruce A, Kapoor A, Tang D. ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function. Oncogene 2006, 25(8):1153-1164.
11. Li Y*, Wu D*, Chen B, Ingram AJ, He L, Liu L, Zhu D, Kapoor A, Tang D. ATM activity contributes to the tumor suppressing functions of p14ARF. Oncogene 2004, 23(44):7355-7365.
12. Wu D, Ingram A, Lahti JH, Mazza B, Grenet J, Kapoor A, Liu L, Kidd VJ, Tang D. Apoptotic release of histones from nucleosomes. J Biol Chem 2002, 277(14): 12001-12008.
13. Tang D, Wu D, Hirao A, Lahti JM, Liu L, Mazza B, Kidd VJ, Mak TW, Ingram AJ. ERKactivation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem 2002, 277(15):12710-12717.
14. Wu DC, Xiao XQ, Ng AKY, Chen PMY, Chung W, Lee NTK, Carlier PR, Pang YP, Yu ACH, Han YF. Protection against ischemic injury in primary cultured mouse astrocytes bybis (7)-tacrine, a novel anti-Alzheimer agent. Neurosci Lett 2000, 288(2): 95-98.
15. Wu DC, Yu YP, Lee NTK, Yu ACH, Wang JHC, Han YF. The Expression of Cdk5, p35,p39 and Cdk5 kinase activity in developing, adult and aged rat brains. Neurochem Res 2000,25(7):923-929.
