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Wei Hou, PH.D

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Office Address: 185# Dong Hu Road, Wuhan University School of Basic Medical Sciences

Position(s): Professor

Affiliation(s): Institute of Medical Virology/State Key Laboratory of Virology

Research interests / Specialties: Viral infection immunity/antiviral research

Education and Training

Senior College Degree, 1988-1991 Hubei Medical University, China

M.D., 1997-2000 Hubei Medical University, China

Visiting Scholar, 2000-2001 Chung Shan Medical University(Taiwan), China

Ph.D., 2003-2006 Wuhan University, China

Visiting Scholar, 2004.9-2004.12 Fukushima Medical University, Japan

Fellow, 2007-2008 University of Pennsylvania School of Medicine, U.S.A

Research Description

My research interests are innate immunity and viral infections, with an emphasis on studying the interactions between host cell innate immunity and HIV/Hantavirus infections. My current research focuses on understanding the role of antiviral factors and mechanisms involved in HIV or Hantavirus infection/replication. I am also interested in drugs of abuse and HIV infection. My team use in vitro, ex vivo and in vivo models to directly address the question of whether drugs of abuse (Opioids and methamphetamine) have the ability to suppress host immune responses and promote HIV diseases. In addition, in collaboration with the investigators at Center for Animal Experiment of Wuhan University where there is an animal biosafety laboratory, my team has established animal models such as non-human primate model for HIV and mouse model for Hantavirus infection. Using these models, they are now exploring the potential of innate immunity activation-based therapy for the treatment of HIV or Hantavirus diseases.

Publication list

1. Zhu, N., Luo, F., Chen, Q.Z., Li, N., Xiong, H.R., Feng, Y., Yang, Z.Q.,Hou, W. (2015) Influence of HLA-DRB alleles on haemorrhagic fever with renal syndrome in a Chinese Han population in Hubei province, China.Euro. J. Clin. Microbiol & Infect. Dis34(1), 187-95.

2. Diao, B., Du, J., Liu, Y., Luo, F.,Hou, W. (2014) The association of HLA-DRB1 alleles and drug use with HIV infection in a Chinese Han cohort.Brazi. J. Infect. Dis.18, 82-87.

3. Liu, Z., Wei, F., Chen, L.J., Xiong, H.R., Liu, Y.Y., Luo, F.,Hou, W., Xiao, H., Yang, Z.Q. (2013) In vitro and in vivo studies of the inhibitory effects of emodin isolated from polygonum cuspidatum on coxsakievirus B4.Molecules18, 11842-11858.

4. Liu, Q., Lu, L., Hua, M.L., Xu, Y., Xiong, H.R.,Hou, W., Yang, Z.Q. (2013) Jiawei-Yupingfeng-Tang, a Chinese herbal formula, inhibits respiratory viral infections in vitro and in vivo.J. Ethnopharmacol150, 521-528.

5. Wei, F., Li, J.L., Ling, J.X., Chen, L.J., Li, N., Liu, Y.Y., Luo, F., Xiong, H.R.,Hou, W., Yang, Z.Q. (2013) Establishment of SYBR green-based qPCR assay for rapid evaluation and quantification for anti-Hantaan virus compounds in vitro and in suckling mice.Virus Genes46, 54-62.

6. Liu, Q., Xiong, H.R., Lu, L., Liu, Y.Y., Luo, F.,Hou, W., Yang, Z.Q. (2013) Antiviral and anti-flammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection.Acta. Pharmacol. Sin. 34, 1075-1083.

7. Ling, J.X., Wei, F., Li, N., Li, J.L., Chen, L.J., Liu, Y.Y., Luo, F., Xiong, H.R.,Hou, W., Yang, Z.Q. (2012) Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea.Acta. Pharmacol. Sin. 33, 1533-1541.

8. Xiong, H.R., Shen, Y.Y., Lu, L.,Hou, W., Luo, F., Xiao, H., Yang, Z.Q. (2012) The inhibitory effect of Rheum palmatum against coxsackievirus B3 in vitro and in vivo.Am. J. Chin. Med. 40, 801-812.

9. Hou, W., Ye, L., Ho, W.Z. (2012) CD56+ T cells inhibit HIV-1 infection of macrophages.J. Leukoy. Biol.92, 343-351.

10. Xiong, H.R., Chen, W., Feng, Y., Luo, F.,Hou, W. (2012) Dynamic expression of TRAIL receptor in Hantavirus-infected HEPF cells.J. Wuhan Univ. (Nat Sci Ed), 58, 337-340.

11. Zhou, L., Li, J.L., Wang, X., Ye, L.,Hou, W., Ho, J., Li, H., Ho, W.Z. (2011) IL-29/IL-28A supress HSV-1 infection of human NT2-N neurons.J. Neurovirol.17, 212-219.

12. Hou, W., Wang, X., Ye, L., Zhou, L., Yang, Z.Q., Riedel, E., Ho, W.Z. (2009) Interferon lambda inhibits HIV-1 infection of macrophages.J. Virol.83, 3834-3842.

13. Wang, X., Ye, L.,Hou, W., Zhou, L., Wang, Y.J., Metzger, D.S., Ho, W.Z. (2009) Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection.Blood113, 671-674.

14. Ye, L., Wang, X., Wang, S.H., Wang, Y.J., Song, L.,Hou, W., Zhou, L., Li, H., Ho, W.Z. (2009) CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes.Hepatology49, 753-762.

15. Luo, F.,Hou, W.,Yang, Z.Q., Tang, Z.J., Wang, Y., Xian, Q.Y., Sun, L.H. (2007) Intratracheal inoculation of severe acute respiratory syndrome coronavirus in monkeys macaca rhesus.Acta Virol.51,171-177.(﹡corresponding author)