XIAOPING SUN, PH.D
E-mail Address: xsun6@whu.edu.cn
Office Address: 185# DongHu Road, Wuhan, Hubei, 430071
Position(s): Professor
Affiliation(s):Department of Pathogen Biology
Research interests / Specialties:
Epstein-Barr virus, Kaposi’s sarcoma-associated herpes virus, small molecular inhibitor
Education and Training
B.S, 1989-1993 Shandong Agricultural University, China
M.S, 1993-1996 Chinese Academy of Agricultural Sciences, China
Research Assistant, 1996-2001 Chinese Academy of Agricultural Sciences,China
Ph.D, 2001-2006 University of Maryland, USA
Post-doctoral training, 2006-2011 University of Wisconsin, USA
Associate Researcher, 2011-2012 University of Wisconsin, USA
Research Description
We are mainly engaged in researches into how small molecular compounds affect Epstein-Barr virus and Kaposi’s sarcoma-associated herpes virus, to explore its mechanisms of viral infection and gene regulation. We also studied the molecular mechanisms of interaction between herpes viral proteins and hot shock protein family members. Projects are supported by NSFC, Ministry of Education (P.R.C.). Ongoing efforts are seeking to: 1) probe the mechanisms of how small molecular inhibitor or hot shock protein inhibitor (Triptolide, PES, etc.) affect EBV or KSHV; 2) probe the interaction between Hsp90 and viral protein.
Publication list
1． Zhou H, Guo W, Long C, Wang H, Wang J, Sun X. Triptolide inhibits proliferation of Epstein-Barr virus-positive B lymphocytes by down-regulating expression of a viral protein LMP1. Biochem Biophys Res Commun. Jan 16 2015;456(3):815-820.
2． Sun X P, Bristol JA, Iwahori S, Hagemeier SR, Meng Q, Barlow EA, Fingeroth JD, Tarakanova VL, Kalejta RF, Kenney SC. （2013）Hsp90 Inhibitor 17-DMAG Decreases Expression of Conserved Herpesvirus Protein Kinases and Reduces Virus Production in Epstein-Barr Virus-Infected Cells. J Virol. 87(18):10126-38.
3． Sun X P, Elizabeth A. Barlow, Shidong Ma, Stacy R. Hagemeier, Sarah J. Duellman, Richard R. Burgess, Judy Tellam, Rajiv Khanna, and Shannon C. Kenney. （2010）. Hsp90 inhibitors block outgrowth of EBV-infected malignant cells in vitro and in vivo through an EBNA1-dependent mechanism. Proceedings of the National Academy of Sciences (PNAS), 107(7):3146-51.
4． Sun X P and Shannon C. Kenney, （2010）. Hsp90 inhibitors: a potential treatment for latent EBV infection? Cell Cycle, 9(9):1665-66.
5． Sun X P and Anne E. Simon, （2006）. A cis-replication element functions in both orientations to enhance replication of Turnip crinkle virus. Virology, 352, 39-51.
6． Sun X P, Zhang G H, and Anne E. Simon, （2005）. Short internal sequences involved in replication and virion accumulation in a subviral RNA of Turnip crinkle virus. J. Virol. 79, 512-524.
7． Sun X P and Anne E. Simon,（2003）. Fitness of a Turnip crinkle virus satellite RNA correlates with a sequence-nonspecific hairpin and flanking sequences that enhance replication and repress the accumulation of virions. J. Virol. 77, 7880-7889.
