Yulin Yuan, MD

E-mail Address: 673568512@qq.com

Office Address: 185# DongHu Road, Wuhan, Hubei, 430071

Position(s):

Assistant professor

Affiliation(s):

Department of Anatomy

Research interests / Specialties:

Dual silencing of the EGF and IGF-1 receptors significantly limits the growth of nasopharyngeal carcinoma in nude mice and nasopharyngeal cancer cells.

Clinical significance of proliferation, apoptosis and senescence of nasopharyngeal cells by the simultaneously blocking EGF, IGF-1 receptors and Bcl-xl genes

Mechanism of escape from accelerated cellular senescence and radioresistance in human nasopharyngeal carcinoma cell with mutant p53 and p16 deficient

Education and Training

B.S., 1996-1999 Wuhan University, China

M.D., 2003-2008 Wuhan University, China

Research Description

My research investigate the molecular mechanisms by which the siRNA cukaryotic expression vectors targeting to EGF receptor and IGF-1 receptor.

The original focus of the lab was the regulation of explored a method of neonatal rat myocardial cells in culture and for therapeutics of cardiac failure, upon completion of master in Department of Anatomy Wuhan University School of Medicine in 1999. We have also begun to take part in research in basic cancer.This led to the development of powerful the design,construction and identification of siRNA cukaryotic expression vectors targeting to EGF receptor and IGF-1 receptor,the effects of dual silencing of EGF receptor and IGF-1 receptor on cell cycle and apoptosis of CNE2 cells, effects of dual silencing of EGF and IGF-1receptor on growth of human nasopharyngeal carcinoma xenograft in nude mice.

Publication list

1. Dai G, Peng T, Zhou X, Zhu J, Kong Z, Ma L, Xiong Z, Yuan Y*. Clinical significance of proliferation, apoptosis and senescence ofnasopharyngeal cells by the simultaneously blocking EGF, IGF-1receptors and Bcl-xl genes. Biochemistry Biophysics Research Communication 440, 479-484, 2013.

2. Xuhong Zhou, Yulin Yuan*, Jian Song, Jun Li, Linfeng Ye, Xiaoping Meng, Dong Xia. Dual silencing of the EGF and IGF-1 receptors significantly limits the growth of nasopharyngeal carcinoma in nude mice. J Laryngol Otol 123(2), 208-222, 2009.

3. Yulin Yuan*, Xuhong Zhou, Jian Song, Xiaoping Qiu, Jun Li, Linfeng Ye, Xiaoping Meng, Dong Xia. Expressions and clinical significances of EGF and IGF-1 receptors in nasopharyngeal carcinoma. ANN OTO RHINOL LARYN 117(3), 192-200, 2008.

4. Yuan YL*, Zhou XH, Song J, Qiu XP, Li Jun, Ye LF. Dual silencing of type 1 insulin-like growth factor and epidermal growth factor receptors to induce apoptosis of nasopharyngeal cancer cells. J Laryngol Otol 122(9), 952-960, 2008.