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Xiaohong Yan, PH.D


Xiaohong Yan, PH.D.

E-mail Address:

Office Address: Building No.1, DongHu Road 185#, Wuhan, Hubei, 430071

Position(s): Professor

Affiliation(s): Department of Physiology

Research interests / Specialties: Bioactive substances on cardiovascular physiology and pathophysiology

Education and Training

B.S., 1982-1987, Wuhan University, School of Medicine, China

M.Sc., 1996-1999, Wuhan University, School of Medicine, China

Ph.D., 2003-2006, Second Military Medical University, Shanghai, China

Visiting Scholar, 2013,10-2013,12. Fukushima Medical University, Japan

Research Description

Study the effects of bioactive substances on cardiovascular physiology and pathophysiology. Mainly study the protective effects of hydrogen sulfide on myocardial ischemia, atherosclerosis and vascular calcification, regulative role of hydrogen sulfide on endoplasmic reticulum stress in cardiovascular diseases and that electrophysiological mechanism of ion channels.

Publication list

1. Yan XH,Sakamoto K, Kimura J. Effects of NaHS on E-4031 sensitive K+ current and apamin-sensitive K+ current in L6 myotubes. Nitric Oxide: Biology and Chemistry Journal 2014, 39:s20 (Third International Conference on H2S Biology and Medicine, Kyoto, Japan. 4-6 June,2014)

2. Wang Y, Ding YL, Deng J, Li CY, Wang ZF,Yan XH *. H2S post-conditioning protect rat myocardium from ischemia reperfusion injury involved in endoplasmic reticulum stress. Nitric Oxide: Biology and Chemistry Journal 2012,27:s26-27(Second International Conference on H2S Biology and Medicine,Atlanta, Georgia, USA. 20-22 September,2012)

3. Ren A, Yan X(co-first author), Lu H, Shi J, Yin Y, Bai J, Yuan W, Lin L. Antagonism of endothelin-1 inhibits hypoxia-induced apoptosis in cardiomyocytes. Can J Physiol Pharmacol 2008;86(8):536-40.

4. Xiao-Hong Y, Li L, Yan-Xia P, Hong L, Wei-Fang R, Yan L, An-Jing R, Chao-Shu T, Wen-Jun Y. Salusins protect neonatal rat cardiomyocytes from serum deprivation-induced celldeath through upregulation of GRP78. J Cardiovasc Pharmacol 2006; 48(2):41-6.

5. Xiaohong Y, Jing-Ping OY, Shuzheng T. Angelica protects human vascular endothelial cells from the oxidization of low-density lipoprotein in vitro. Clin Hemorheol Microcirc 2000; 22(4):317-23.

6. Pan YX, Ren AJ, Zheng J, Rong WF, Chen H, Yan XH, Wu C, Yuan WJ, Lin L. Delayed cytoprotection induced by hypoxic preconditioning in cultured neonatal rat cardiomyocytes: Role of GRP78. Life Sciences 2007, 81:1042-1049.

7. Ren AJ, Yuan X, Lin L, Xu J, Chen T, Wang WZ, Yan XH, Qing YW, Tang CS, Yuan WJ. Arrhythmogenic action of endothelin-1(1-31) through conversion toendothelin-1(1-21). Exp Biol Med (Maywood) 2006; 231(6):937-41.

8. Zhu XY, Yan XH*(corresponding author), Chen SJ. H2S protects myocardium against ischemia/reperfusion injury and its effect on c-Fos protein expression in rats. Acta Physiologica Sinica 2008; 60(2):221-7.

9. Zhui Y, Jing-Ping OY, Yongming L, Lei W, Shuzheng T, Hailu Y, Hanqiao Z, Xiaohong Y. Experimental study of the anti-atherogenesis effects and mechanisms of Chinese medicine Angelica. Clin Hemorheol Microcirc 2000; 22(4):305-10.

10. Lu Y, Wang WZ, Liao Z, Yan XH, Tang CS, Yuan WJ. Blood pressure responses of endothelin-1 1-31 within the rostral ventrolateralmedulla through conversion to endothelin-1 1-21. J Cardiovasc Pharmacol 2005,46(6):823-9.