Lin Wang, MD,PH.D

E-mail Address: lin.wang@whu.edu.cn

Office Address: 185# DongHu Road, Wuhan, Hubei, 430071

Position(s): Chair and Professor, MD, PhD

Affiliation(s):Department of Histology and Embryology

Research interests / Specialties:

Reproductive Biology and \or Neonatal infectious diseases

Education and Training

B.D., 1983-1988 Wuhan University School of Medicine, China

M.D..1996-1998 Wuhan University School of Medicine, China

Ph.D., 2002-2006 Wuhan University, China

Post-doctoral training, 2008-2010 University of Southern California, U.S.A

Research Description

1. Reproductive Biology: We focus our research on the molecular mechanism of implantation of embryo and the influence of adverse intrauterine environment on the development of fetus.

2. Neonatal infectious diseases: Our research interests focus on the molecular mechanism how neonatal meningitic Escherichia coli penetrate across blood brain barrier using cell and animal model.

Publication list

1.XIAOLI ZHANG, LIN WANG, FENGHUA HUANG, JIAFU LI, LI XIONG, HAN XUE and YUANZHEN ZHANG. Evaluation of the promoter region polymorphism (5 HTTLPR) in the serotonin transporter gene in females with postpartum depression. EXPERIMENTAL AND THERAPEUTIC MEDICINE 9: 245-249, 2015

2. Zhang X, Wang L, Huang F, Li J, Xiong L, Xue H, Zhang Y. Gene-environment interaction in postpartum depression: a Chinese clinical study. J Affect Disord. 2014 Aug;165:208-12. doi: 10.1016/j.jad.2014.04.049. Epub 2014 Apr 30.

3. Sheng-He HuangΔ*, Lin Wang Δ, Feng ChiΔ（ΔThese authors contributed equally to this work),Chun-Hua Wu1, Hong Cao2, Aimin Zhang1,4, Ambrose Jong1. Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood–brain barrier disorders caused by microbial and non-microbial factors. PLoS One. 2013 Apr 26;8(4):e62164. doi: 10.1371/journal.pone.0062164.

4. Lina He, Feng Chi, Tao Bo1, Lin Wang, Chun-Hua Wu, Ambrose Jong, Sheng-He huang* p54nrb, a PSF protein partner, contributes to meningitic Escherichia coli K1-mediated pathogenicities. Open Journal of Applied Sciences 2012, Paper ID:2310016/ojapps.2012.Published Online. 2012

5. Feng ChiΔ, Lin WangΔ(ΔThese authors contributed equally to this work), Xueye Zheng, Chun-Hu Wu, Ambrose Jong,Michael A. Sheard, Wei Chi, Sheng-He Huang*. Meningitic Escherichia coli K1 Penetration and Neutrophil Transmigration Across the Blood–Brain Barrier are Modulated by Alpha7 Nicotinic Receptor. PLOS ONE, 6(9):e25016. Epub 2011 Sep 22，2011

6. Feng ChiΔ, Lin WangΔ（ΔThese authors contributed equally to this work), Xueye Zheng, Ambrose Jong, Sheng-He Huang*. Recruitment of α7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells. Future Microbiology, 6:953-66，2011;Aug

7. Xiaojuan CheΔ, Feng ChiΔ, Lin WangΔ(ΔThese authors contributed equally to this work), Timothy D. Jong, Chun-Hu Wu, Xiaoning Wang, Sheng-He Huang*. Involvement of IbeA in meningitic Escherichia coli K1-induced Polymorphonuclear leukocyte transmigration across brain endothelial cells. Brain Pathology 21(4):389-404，2011 Jul;

8. Chi F, Jong T, Wang L, Ouyang Y, Wu CH, Li W, Huang SH*. Vimentin-mediated signaling is required.for IbeA+ E. coli K1 invasion of human brain microvascular endothelial cells. Biochem J. 427:79-90，2010

9. Lin Wang, Li Zhou.Role of caveolin - 1 in the entry of HCMV into human extravillous trophoblast cells，FASEB J. 2010，24:822.4.

10. XIONG Guoping，LIU Xiaohua，WANG Lin*, Dynamic Changes of Survivin in Mouse Endometria During Implantation. Medical Journal of Wuhan University, 2013, 34(3): 348-351

11. Cheng xiujuan, Xiong guoping, Wang Lin*, Expression of β-Tublin in the implantation or Non implantation site of oviduct pregnancy. Chinese journal of histochemistry and cytochemistry 2013,22(2):132-134

12. Weng Ruiguang, Zhang Jianjian, Wang Lin*.Effects of cerebral ischemia reperfusion on apoptosis and neurogenesis in the hippocampus of aged mice. Chinese journal of histochemistry and cytochemistry, 2014,23(5):501-505

13. Liu Jun, Wang Qianhua, Zhou Li, Wang Lin* .Dynamic changes of caveolin-1 in mouse endometrial during implantation. Chinese journal of histochemistry and cytochemistry,2012,21(5):486-490