Liu He, PH.D

E-mail Address:

anne19831026@hotmail.com

Office Address:

185# DongHu Road, Wuhan, Hubei, 430071

Position(s):

Postdoctor

Affiliation(s):

Department of Anatomy and Embryology

Research interests / Specialties:

The spontaneous transformation of mesenchymal stem cell

Education and Training

2002．9——2007．7Central south university xiangya school of medicine Bachelor

2009．9——2011．7Department of Anatomy and Embryology, Wuhan University School of Medicine Master

2011．9——2014．7Department of Anatomy and Embryology, Wuhan University School of Medicine Docter

2014．9——2016．7Department of Anatomy and Embryology, Wuhan University School of Medicine Postdocter

Research Description

My research investigate the molecular mechanisms by which mesenchymal stem cell (MSC) spontaneously transformed.

The original focus of the lab was to investigate the changes in survivin expression and biological characteristics of MSC after spontaneous transformation in vitro.

MSC from various animals undergo spontaneous transformation in vitro, establishing some malignant characteristics. However, this phenomenon seems seldom appearing in human (h) MSC. To address the question whether the hMSC really do not undergo the spontaneous transformation and why, we have compared the MSCs from two species under the same conditions. In conclusion, the hMSCs do not spontaneously initiate transformation because they can not escape senescence. This is particularly due to their much shorter telomere.

Publication list

1. He L, Zheng Y, Wan Y, Song J. A Shorter Telomere is the Key Factor Preventing Cultured Human Mesenchymal Stem Cells from Senescence-escaping. Histochem Cell Biol. 2014, 142:257-267.

2. Zheng Y, He L, Wan Y, Song J. H3K9me-Enhanced DNA Hypermethylation of the p16(INK4a) Gene: An Epigenetic Signature for Spontaneous Transformation of Rat Mesenchymal Stem Cells. Stem Cells Dev. 2013;15;22(2):256-67.