Honglei Chen, M.D., PH.D,
E-mail Address: hl-chen@whu.edu.cn
Office Address: 185# DongHu Road, Wuhan, Hubei, 430071
Position(s):
Associate Professor
Affiliation(s):
Department of Pathology
Research interests / Specialties:
Tumor energy metabolism and\or autophagy and the invasion and metastasis of cancer
Education and Training
Medical Degree., 1994-1999 Xianning Medical College, China
Ph.D., 2005-2010 Renmin Hospital of Wuhan University, China
Post-doctoral training, 2012-2013 Medical Center of Rush University, U.S.A
Research Description
My research interest focus on the following three areas: 1) the role of caveolin-1 in the development, progress and metastasis of cancer; 2) autophagy, energy metabolism and carcinogenesis; and 3) quantum dots application in cancer imaging. The major goal of these studies is to clarify some novel mechanism on the invasion and metastasis of cancer.
We have also begun to explore the new method to detect circulating tumor cells of malignant tumors.
Publication list
1. Qu Y, Zhang Q, Pan Q, Zhao X, Huang Y, Chen F, Chen H. (2014) Quantum dots immunofluorescence histochemical detection of EGFR gene mutations in the non-small cell lung cancers using mutation-specific antibodies. Int J Nanomed, 9(1):5771-8.
2. Zhao H, Zhang X, Chen X, Li Y, Ke Z, Tang T, Chai H, Guo AM, Chen H*, Yang J*.(2014) Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. Toxicol Appl Pharmacol. 2014, 279(3):311-21.
3. Chen H, Wu S, Lu R, Zhang Y, Zheng Y, Sun J. (2014) Pulmonary permeability assessed by fluoresce-labeled dextran instilled intranasally into mice with LPS-induced acute lung injury. PLoS One, 9(7): e101925.
4. He Y, Zhao X, Subahan NR, Fan L, Gao J, Chen H. (2014) The Prognostic Value of Autophagic Related Markers Beclin-1 and Light Chain 3 in Cancers: A Systematic Review and Meta-analysis. Tumor Biology, 35(8):7317-26.
5. Zhao X, He Y, Gao J, Fan L, Li Z, Yang G, Chen H.(2013) Caveolin-1 expression level in cancer associated fibroblasts predicts outcome in gastric cancer. PLoS One, 8(2):e59102
6. Zhao X, He Y, Chen H. (2013) Autophagic tumor stroma: Mechanisms and roles in tumor growth and progression. Int J Cancer. 132(1):1-8.
7. He Y, Zhao X, Gao J, Fan L, Yang G, Cho WC, Chen H. (2012) Quantum dots-based immunofluorescent imaging of stromal fibroblasts caveolin-1 and light chain 3B expression and identification of their clinical significance in human gastric cancer. Int J Mol Sci, 13(11):13764-80.
8. Sun J, Gao J, Hu JB, Fan LF, Zhu XB, Subahan Roz, Chen HL.(2012) Expression of Cav-1 in tumour cells, rather than in stromal tissue, may promote cervical squamous cell carcinomaproliferation, and correlates with high-risk HPV infection. Oncol Rep, 27(6):1733-40.
9. Peng J*, Chen HL*, Zhu XB, Yang GF, Zhang ZL, Tian ZQ, Pang DW. (2011) Detection of Epstein-Barr virus infection in gastric carcinomas using quantum dot-based fluorescence in-situ hybridization. J Nanosci Nanotechno, 11(11):9725-30.
10. Li ZH, Peng J, Chen HL.(2011) Bioconjugated quantum dots as fluorescent probes for biomedical imaging. J Nanosci Nanotechno, 11(9): 7521-36.
11. Chen HL, Fan LF, Gao J, Ouyang JP, Zhang YX. (2011) Differential expression and function of caveolin-1 gene in non-small cell lung carcinoma. Oncol Rep, 25(2):359-66.
12. Chen HL, Peng J, Zhu XB, Gao J, Xue JL, Wang MW, Xia HS. (2010) Detection of EBV in nasopharyngeal carcinoma by quantum dot fluorescent in situ hybridization. Exp Mol Pathol. 89(3):367-71.
13. Chen H, Xue J, Zhang Y, Zhu X, Gao J, Yu B. (2009) Comparison of quantum dots immunofluorescence histochemistry and conventional immunohistochemistry for the detection of caveolin-1 and PCNA in the lung cancer tissue microarray. J Mol Histol. 40(4):261-8.
Ye B, Zhang YX, Yang F, Chen HL, Xia D, Liu MQ, Lai BT. (2007) Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl) -1-butanone and its inhibition by aspirin and phenethyl isothiocyanate. BMC Cancer, 7:90.
