Deling Zhang, Ph.D
E-mail Address: zdlme@whu.edu.cn
Office Address: 185# DongHu Road, Wuhan, Hubei, China, 430071
Position(s): Lecturer
Affiliation(s):Department of Pathophysiology
Research interests / Specialties:
The molecular pathway mediating adiponectin signaling.
Education and Training
B.S.,1997.9-2002.6, Wuhan University School of Medicine, China
Ph.D., 2002.9-2010.6, Wuhan University School of Medicine, China
Visiting Scholar, 2013.10-2015.5, University of Texas Health Science Center in San Antonio, U.S.A
Research Description:
My research focus on exploring the molecular pathway mediating adiponectin signaling and function in diabetes. My research show HSP60 is a potential adiponectin signaling molecule in term of diabetic myocardial protection of adiponectin. Our lab also found TCTP is a binding partner of APPL2 negatively regulate adiponectin signaling in the liver. These findings will provide potential mechanisms behind insulin resistance, the development of type 2 diabetes, and diabetic related cardiovascular diseases, which helps to explore new methods for prevention and treatment of diabetes.
Publication list
1. Zhang D, Ouyang J, Wang N, Zhang Y, Bie J, Zhang Y. Promotion of PDGF-induced endothelial cell migration by phosphorylated VASP depends on PKA anchoring via AKAP. Molecular and cellular biochemistry. 2010;335(1-2):1-11.
2. Wang N1, Zhang D1, Mao X1, Zou F, Jin H, Ouyang J. Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes. Molecular and cellular endocrinology. 2009;307(1-2):89-98. (1: co- first auther )
3. Deling Zhang, Jingping Ouyang,Yongming Liu, Nian Wang. Inhibition of VASP gene expression on HUVEC by antisense oligonucleotides. Journal of Biomedical Engineering. 2005;22(3):149-150.
4. Zhang Deling, Dong Feng, Ouyang Jingping, Lu Yanzhen, Ma Chenyan, Zheng Hanqiao. Protective Effects of Non-wounded Preconditioning on Ischemia Heart in Rats. Chinese Joural of Microcirculation. 2003;13 (4) :16-17, 62. (Article in Chinese)
5. Liu J, Zhang JF, Lu JZ, Zhang DL, Li K, Su K, Wang J, Zhang YM, Wang N, Yang ST, Bu L, Ou-Yang JP. Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBC1D4 phosphorylation. Acta Pharmacologica Sinica. 2013;34 (1):137-145.
6. Zhang Yahui, Zhang Deling, Ouyang Jingping. Effect of VASP mutant phosphorylation on migration of endothelial cells induced by PDGF-BB. Chinese Journal of Pathophysiology, 2010;26(1):32-36. (Article in Chinese)
