Wanhong Liu, Ph.D

E-mail Address: liuwanhong@whu.edu.cn

Office Address: 185# DongHu Road, Wuhan, Hubei, 430071

Position(s): Professor and Assistant School Dean

Affiliation(s):Department of Immunology

Research interests / Specialties:

Viral Immunology and Molecular Virology, Neural Immunology and Molecular Neurology

Education and Training

B.S., 1990-1994 Wuhan University, China

M.S., 1999-2002 Wuhan University, China

Ph.D., 2002-2005 Wuhan University, China

Post-doctoral training, 2007-2008 National University of Singapore, Singapore

Visiting Scholar, 2014-2015 Texas A&M University, USA

Research Description

The research focuses on HFV (Human foamy virus, also called Prototype foamy virus) infection, the interaction between HFV and host cells (including proteins and non-coding RNAs), the molecular biology of viral replication, innate immunity control of viral replication, gene therapy by HFV vector.

Figure 1. The genomic organization of FVs and Tas of FVs interacted with other proteins in cells

2. The research focuses on EV71 (Human Enterovirus 71) and CA16 (Coxsachievirus A16) infection and pathogenic mechanism, especially the interaction between EV71/ CA16 and neural cells to leading to the hand, foot and mouth disease (HFMD) frequently accompanied by severe neurological complications, new vaccine or antiviral drug screening and development.

Figure 2. A sandwich-switch hypothesis developed from the 3D structure of the VP1 protein

Publication List

1. Shi Y, He X, Zhu G, Tu H, Liu Z, Li W, Han S, Yin J, Peng B, Liu W*. Coxsackievirus A16 Elicits Incomplete Autophagy Involving the mTOR and ERK Pathways. PLoS One. 2015 Apr 8;10(4):e0122109. doi: 10.1371/journal.pone.0122109. eCollection 2015. （*Corresponding Author ）

2. Dong L, Cheng Q, Wang Z, Yuan P, Li Z, Sun Y, Han S, Yin J, Peng B, He X*, Liu W*. Human Pirh2 is A Novel Inhibitor of Prototype Foamy Virus Replication. Viruses. 2015 Apr 2;7(4):1668-84. doi: 10.3390/v7041668. （*Corresponding Author ）

3. Liu Y, Zhang F, Fu C, Wu S, Chen X, Shi Y, Zhou B, Zhang L, Zhang Y, Han S, Yin J, Peng B, He X*, Liu W*. Combination of intratypic and intertypic recombinant events in EV71: a novel evidence for the "triple-recombinant" strains of genotype A viruses in Mainland China from 2008 to 2010. Virus Genes. 2015 Jun;50(3):365-74. （*Corresponding Author）

4. Zhang F, Liu Y, Chen X, Dong L, Zhou B, Cheng Q, Han S, Liu Z, Peng B, He X*, Liu W*. RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT. Biochem Biophys Res Commun. 2015 Mar 20;458(4):810-5. doi: 10.1016/j.bbrc.2015.02.035. Epub 2015 Feb 19. （*Corresponding Author ）

5. Cheng Q, Dong L, Zhang F, Yuan P, Li Z, Sun Y, Yin J, Peng B, He X*, Liu W*. Efficiently inhibiting HIV-1 replication by a prototype foamy virus vector expressing novel H1 promoter-driven short hairpin RNAs. AIDS Res Hum Retroviruses. 2015 Feb;31(2):183-8. doi: 10.1089/AID.2014.0217. Epub 2015 Jan 22. （*Corresponding Author ）

6. Wang Z, Fan Y, Xu J, Li L, Heng D, Han S, Yin J, Peng B, Liu W*, He X*. Transcriptome analysis of the hippocampus in novel rat model of febrile seizures. PLoS One. 2014 Apr 15;9(4):e95237. （*Corresponding Author ）

7. Liu Y, Fu C, Wu S, Chen X, Shi Y, Zhou B, Zhang L, Zhang F, Wang Z, Zhang Y, Fan C, Han S, Yin J, Peng B, Liu W*, He X*. A novel finding for enterovirus virulence from the capsid protein VP1 of EV71 circulating in mainland China. Virus Genes. 2014 Apr;48(2):260-72. （*Corresponding Author）

8. Zhang L, Chen X, Shi Y, Zhou B, Du C, Liu Y, Han S, Yin J, Peng B, He X*, Liu W*. miR-27a suppresses EV71 replication by directly targeting EGFR.. Virus Genes. 2014 Dec;49(3):373-82.（*Corresponding Author）

9. Zhu G, Zheng Y, Zhang L, Shi Y, Li W, Liu Z, Peng B, Yin J, Liu W*, He X. Coxsackievirus A16 infection triggers apoptosis in RD cells by inducing ER stress. Biochem Biophys Res Commun. 2013 Nov 29;441(4):856-61. （*Corresponding Author）

10. Liu Z#, Liu W#, Yao L, Yang C, Xiao L, Wan Q, Gao K, Wang H, Zhu F, Wang G, Xiao Z. Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder. Sci Rep. 2013;3:1548.（#Co-first Author）

11. Li Z#, Liu WH#, Han S, Peng BW, Yin J, Wu YL, He XH, Li WX. Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model. J Biol Chem. 2012 Aug 24;287(35):29479-94.（#Co-first Author）

12. Wang Z, Yang B, Dong L, Peng B, He X*, Liu W*. A novel oncoprotein Pirh2: rising from the shadow of MDM2. Cancer Sci. 2011 May;102(5):909-17. （*Corresponding Author）

13. Zhang Y, Liu Y, Zhu G, Qiu Y, Peng B, Yin J, Liu W*, He X*. Foamy virus: an available vector for gene transfer in neural cells and other nondividing cells. J Neurovirol. 2010 Nov;16(6):419-26. （*Corresponding Author）

14. Liu W*, Liu Z, Liu L, Xiao Z, Cao X, Cao Z, Xue L, Miao L, He X*, Li W. A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury. Neurosci Lett. 2008 Feb 13;432(1):13-8. （*Corresponding Author）

Liu W, Liu Z, Cao X, Cao Z, Xue L, Zhu F, He X, Li W. Recombinant human foamy virus, a novel vector for neurological disorders gene therapy, drives production of GAD in cultured astrocytes. Mol Ther. 2007 Oct;15(10):1834-41.