Changhua Wang, PH.D

E-mail Address: chwang0525@whu.edu.cn

Office Address: 185 Donghu Road, Wuhan, 430071

Position(s): Professor & Director

Affiliation(s): Department of Pathophysiology

Research interests/Specialties: Diabetes

Education and Training

B.M.S., 1983-1988 Wuhan University School of Medicine, China

M. S., 1988-1991 Wuhan University School of Medicine, China

Ph.D., 1998-2001 Wuhan University School of Medicine, China

Research Description

Our research interest focuses on the fundamental mechanisms underlying obesity, diabetes, and its related diseases including cancer. Currently we are investigating the regulatory role of protein quality control, particularly protein degradation induced by autophagy and proteasome, in obesity-related cancer development and adipocyte function. We also study the crosstalk between autophagy and proteasome in cancer cells and adipocytes.

Publication list

1. Yao X, Liu H, Zhang X, Zhang L, Li X, Wang C, Sun S. Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3. PLoS One. 2015 May 14;10(5):e0125634.

2. Zhang Y, Ye M, Chen LJ, Li M, Tang Z, Wang C. Role of the ubiquitin-proteasome system and autophagy in regulation of insulin sensitivity in serum-starved 3T3-L1 adipocytes. Endocr J. 2015 May 10. [Epub ahead of print]. PubMed PMID: 25959705.

3. Zhang Y, Li M, Tang Z, Wang C. Wogonin suppresses osteopontin expression in adipocytes by activating PPARα. Acta Pharmacologica Sinica. 2015 Jun 15. [Epub ahead of print]. doi: 10.1038/aps.2015.37

4. Wang C, Wang X. The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity. Biochim Biophys Acta. 2015 Feb;1852(2):188-94.

5. Tian Z, Wang C, Hu C, Tian Y, Liu J, Wang X. Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes. PLoS One. 2014 Jun 24;9(6):e100715.

6. Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, White MF, Liu F, Dong LQ. APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor. Cell Rep. 2014 May 22;7(4):1227-38.

7. Liu YM, Wang X, Nawaz A, Kong ZH, Hong Y, Wang CH, Zhang JJ. Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. Acta Pharmacol Sin. 2011Dec;32(12):1475-82.

8. Deepa SS, Zhou L, Ryu J, Wang C, Mao X, Li C, Zhang N, Musi N, DeFronzo RA, Liu F, Dong LQ. APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway. Mol Endocrinol. 2011Oct;25(10):1773-85.

9. Sun S, Liu Y, Lu J, Omar A, Sun S, Bi Y, Wang C. The inhibitory effects of PKCθ on adiponectin expression is mediated by ERK in 3T3-L1 adipocytes. J Endocrinol Invest. 2011 Jan;34(1):8-15.

10. Sun S, Wang X, Wang C, Nawaz A, Wei W, Li J, Wang L, Yu DH. Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells. Planta Med. 2011 Jan;77(2):141-5.

11. Wang X, Yu W, Nawaz A, Guan F, Sun S, Wang C. Palmitate induced insulin resistance by PKCtheta-dependent activation of mTOR/S6K pathway in C2C12 myotubes. Exp Clin Endocrinol Diabetes. 2010 Oct;118(9):657-61.

12. Wang C, Xin X, Xiang R, Ramos FJ, Liu M, Lee HJ, Chen H, Mao X, Kikani CK, Liu F, Dong LQ. Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells. J Biol Chem. 2009 Nov 13;284(46):31608-15.

13. Wang C, Liu M, Riojas RA, Xin X, Gao Z, Zeng R, Wu J, Dong LQ, Liu F. Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance. J Biol Chem. 2009 Jan 23;284(4):2038-44.

14. Wang C, Mao X, Wang L, Liu M, Wetzel MD, Guan KL, Dong LQ, Liu F. Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1. J Biol Chem. 2007 Mar 16;282(11):7991-6.

15. Riojas RA, Kikani CK, Wang C, Mao X, Zhou L, Langlais PR, Hu D, Roberts JL, Dong LQ, Liu F. Fine tuning PDK1 activity by phosphorylation at Ser163. J Biol Chem. 2006 Aug 4;281(31):21588-93.