Lei Wei, MD&PH.D
E-mail Address: leiweifr@hotmail.com
Office Address: 185# DongHu Road, Wuhan, Hubei, 430071
Position(s):
Professor
Affiliation(s):
Department of Pathology and Pathophysiology, School of Basic Medical Sciences
Research interests / Specialties:
Cytoskeleton reorganization mechanics and the pathogenesis of Cancer metastasis and Cardiovascular disease entailing both basic and clinical science
Education and Training
M.B., 1987-1992 Hubei Medical University, China
M.M., 1995-1998 Hubei Medical University, China
M.D&Ph.D., 2000-2004 Joint program of Faculté de médecine de Nancy, UHP, France and School of Basic Medical Sciences, Wuhan University, China
Research Description
The actin cytoskeleton mediates numerous cellular processes including adhesion, motility and shape change. Dysfunctional actin cytoskeleton is associated with diseases such as metastatic cancers. As a key regulator of actin cytoskeleton, VASP is a member of the Ena/VASP protein family which is recruited downstream of plasma membrane receptors and plays crucial roles in the regulation of cell adhesion, migration and cell-cell interaction.
Vasodilator-stimulated phosphoprotein (VASP) has been implicated in the establishment of cancerous phenotypes. However, the role of VASP in solid tumors progression and metastasis remains poorly understood. Here, we demonstrated that VASP was upregulated by epidermal growth factor (EGF) and promoted the migration and invasion of gastric cancer cells. Then we explored the regulatory mechanisms responsible for high expression of VASP mainly in gastric cancer and breast cancer.
Publication list (*correspondent author)
1. Tang Menjie, Tian Yihao, Li Doulin, Lv Jiawei, Li Qun, Kuang Changchun, Hu Pengchao, Wang Ying, Wang Jing, Su Ke, Wei L * TNF-α mediated increase of HIF-1α inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI).PLoS One. 2014 Jul 22;9(7):e102967. doi: 10.1371/journal. pone. 0102967. eCollection 2014.
2. Liu Min, Qin Jian, Hao Yarong, Liu Min, Luo Jun, Luo Tao, Wei Lei *. Astragalus Polysaccharide Suppresses Skeletal Muscle Myostatin Expression in Diabetes: Involvement of ROS-ERK and NF-κB Pathways. Oxidative Medicine and Cellular Longevity. 2013 (2013), Article ID 782497, 10 pageshttp://dx.doi.org/10.1155/2013/782497
3. Zhang Jingwei, Su Ke, Shi WenTao, Wang Ying, Hu PengChao, Wang Yang, Wei Lei, Xiang Jin, Yang Fang. Matrine inhibits adhesion and the migration of BGC823 grastric cancer cells by affecting the structure and function of vasodilator-stimulated phosphoprotein (VASP). Acta Pharmacol. Sin. 2013, 34(8):1084-1092.
4. Shi WT, Wei L△, Xiang J, Su K, Ding Q, Tang MJ, Li JQ, Guo Y, Wang P, Zhang JW. Chinese patients with gastric cancer need targeted adjuvant chemotherapy schemes. Asian Pac J Cancer Prev. 2012;13(10):5263-5272.(△ equal contribution)
5. Su K, Tian Y, Wang J, Shi W, Luo D, Liu J, Tong Z, Wu J, Zhang J*, Wei L*. HIF-1α Acts Downstream of TNF-α to Inhibit Vasodilator-Stimulated Phosphoprotein Expression and Modulates the Adhesion and Proliferation of Breast Cancer Cells. DNA Cell Biol. 2012, 31(6):1078-1087.
6. Wang Jing, Zhang Jingwei, Wu Junzhu, Daji Luo, Su Ke, Shi Wentao, Liu Jian, Tian Yihao, Wei Lei*. MicroRNA-610 inhibits the migration and invasion of gastric cancer cells by suppressing the expression of vasodilator-stimulated phosphoprotein. European Journal of Cancer. 2012, 48:1904-1813.
7. Wu G, Wei L, Yu A, Zhang M, Qi B, Su K, Hu X, Wang J. Vasodilator-stimulated phosphoprotein regulates osteosarcoma cell migration. Oncology Reports 2011, 26(6):1609-1615.
8. Wang Yongping, Dong Huimin, Zhu Meng, Ou Yangwen, Zhang Jie, Luo Hesheng, Luo Ruoyu, Wu Junzhu, Mao Ming, Liu Xiaoheng, Zhang Jingwei, Wei Lei*. Icariin exterts negative effects on human gastric cancer cell invasion and migration by vasodilator-stimulated phosphoprotein via Rac1 pathway. European Journal of Pharmacology. 2010; 635(1-3):40-48.
9. Li Hua, Zhang Lijun, Zhou Xuan, Wu Junzhu, Yu Hong, Wei Lei*. Inhibitory effect of Paclitaxel on endothelial cell adhesion and migration. Pharmacology. 2010; 85(3):136-145.
10. Zhang YM, Han GG, Fan B, Zhou YF, Wei L*, Zhang JW*. Green Tea (-)-Epigallocatechin-3-Gallate Down-regulates VASP Expression and Inhibits Breast Cancer Cell Migration and Invasion by Attenuates Rac1 Activity. European Journal of Pharmacology. 2009; 606(1-3):172-179.
11. He C, Huang R, Du F, Zheng F, Wei L, Wu J*. LDL oxidation by THP-1 monocytes: implication of HNP-1, SgIII and DMT-1.Clin Chim Acta. 2009; 402(1-2):102-106.
12. Zhang YM, Yao F, Yao XL, Yi CH, Tan C, Wei, L, Sun SR. Role of CCL5 in invasion, proliferation and proportion of CD44+/CD24(-) phenotype of MCF-7 cells and correlation of CCL5 and CCR5 expression with breast cancer progression. Oncology Reports 2009, 21(4):1113-1121
Guoge Han, Biao Fan, Yimin Zhang, Xuan Zhou, Yongping Wang, Huimin Dong, Yun Wei, Shengrong Sun, Mingbo Hu, Jingwei Zhang*, Lei Wei*. Positive regulation of migration and invasion by vasodialator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells. Oncology Reports 2008, 20(4):929-939
