Jingling Xue, PH.D

E-mail Address:495018599@qq.com

Office Address: 185# DongHu Road, Wuhan, Hubei, 430071

Position(s):

A ssociated Professor

Affiliation(s):

Department of Physiology and Pathology

Research interests / Specialties:

Tumoric pathology and tumorigenesis

Education and Training

B.S., 1994-1999 Hubei Medical College, China

Ph.D. 1999-2003 Wuhan University School of Medicine,, China

Post-doctoral training, 2014-2015 University of Houston ,U .S.A

Research Description

Tumorigenesis of human cancers is thought to be a multistep process where certain mutations confer a selective advantage to the cells, allowing lineages derived from the mutated cells to outcompete others. Although molecular cell biology has substantially advanced cancer research, the mechanism remains unclear. Determination of the expression and spatial distribution of molecular epitopes, or antigens, in patient tissue specimens has substantially improved the pathologist's ability to classify disease processes. Certain aspects of tumor pathophysiology are marked by characteristic increased or decreased expression of some proteins. Our goals of tumor research are to identifying these molecular targets or markers.

I have been mainly engaged in the study of pathology of diseases, particularly trying to understand mechanisms of progression and invasion of oral cancer. I have investigated the role of HPV in squamous cell carcinoma of the tongue, by using a new technology (QDs immunohistochemistry). I have also investigated the role of caveolin-1 in tongue cancer including expression arrays of normal, dysplastic and carcinoma tissue by Quantum dots. I have found that QDs-IHC is a very sensitive and specific method in detecting some micro-levels of proteins and factors in oral tissue. I hope to apply this technique to identify new biomarkers in cancers and premalignant tissues (in vivo and in vitro).

Publication list

1. Xue J, Chen H, Diao L, Chen X, Xia D.(2010) Expression of caveolin-1 in tongue squamous cell carcinoma by quantum dots. Eur J Histochem. 14;54 (2):e20.

2. Xue J, Chen H, Fan M, Zhu F, Diao L, Chen X, Fan L, Li P, Xia D.(2009) Use of quantum dots to detect human papillomavirus in oral squamous cell carcinoma. J Oral Pathol Med. 38 (8):668-71.

3. Chen H, Xue J(Co- first author), Zhang Y, Zhu X, Gao J, Yu B.(2009)

Comparison of quantum dots immunofluorescence histochemistry and

conventional immunohistochemistry for the detection of caveolin-1 and PCNA

in the lung cancer tissue microarray. J Mol Histol. 40 (4):261-8.

4. Xue J, Fan M, Wang S, Chen X , Li Y, Wang L.(2005) A clinical study of

674 patients with OLP in China.J Oral Pathology Medicine. 34 (8):467-472