Yinping Li, PH.D

Email Address: liyinping@whu.edu.cn

Office Address: 185# DongHu Road, Wuhan, Hubei, 430071

Position(s): Associate Professor

Affiliation(s):Department of Pathophysiology

Research interests / Specialties:

Mesenchymal stem cells and immune regulation; Mesenchymal stem cells and tissue engineering

Education and Training

B.S.Med, 1995-2000 Wuhan University, China

Ph.D., 2000-2006 Wuhan University, China

Ph.D., 2003-2007 Lorraine University, France

Visiting Scholar, 2014.7-2014.9 Lorraine University, France

Research Description

My research investigate the immunoregulatory role of mesenchymal stem cells (MSC) in context of inflammation and the potential molecular mechanisms.

We have shown that MSC have important role in regulating immune response, for example, they can induce differentiation of regulatory dendritic cells and further regulatory T cells through both cell-cell contact and soluble factors, and notch signaling may be involved. Infusion of MSC into models of type 1 diabetes may ameliorate tissue injury in pancreas as well as insulin level. However, in models of LPS induced endotoxemia, infusion of MSC was shown to be unfavorable. So, what might be the mechanisms underlined for different role of MSC in regulating immune response and inflammation? Toll-like receptors (TLR) may be involved. We try to investigate possible effects of TLR on regulatory function of MSC.

As MSC are also important seed cells for tissue engineering, we also began to investigate how to construct ideal “bone tissue” in combination of MSC and biomaterials.

Publication list

1. Luo L, Gong W, Zhou Y, Yang L, Li D, Huselstein C, Wang X, He X, Li Y,

Chen Y. Cellulose/soy protein isolate composite membranes: evaluations of in vitro cytocompatibility with Schwann cells and in vivo toxicity to animals. Biomed Mater Eng, 2015;25(1 Suppl):57-64.

2. Du X, Li Y, Liu X, Wang X, Huselstein C, Zhao Y, Chang PR, Chen Y. Fabrication and evaluation of physical properties and cytotoxicity of zein-based polyurethanes. J Mater Sci Mater Med. 2014 Mar;25(3):823-33.4．Eljaafari A, Li YP, Miossec P. IFNγ, as secreted during an alloresponse, induces differentiation of monocytes into tolerogenic dendritic cells resulting in FoxP3+ regulatory T cell promotion. Journal of Immunology. 2009, 183:2932-2945.

5. Li YP, Paczesny S, Lauret E, Poirault S, Bordigoni P, Mekhloufi F, Hecquet

O, Ou-Yang JP, Stoltz JF, Miossec P, Eljaafari A. Human mesenchymal stem cells license adult CD34+ hematopoietic progenitor cells to differentiate into regulatory dendritic cells through activation of the NOTCH pathway. Journal of Immunology, 2008, 180(3):1598-608.