Lang Chen,M.D, Ph.D

E-mail Address: langchen@whu.edu.cn

Office Address: 1-329, 185, Wuhan University School of Basic Medical Sciences

Position(s): Lecturer

Affiliation(s): Department of Immunology

Research interests / Specialties: Innate Immunity

Education and Training

1997-2002, Wuhan University, MD in Clinic Medication

2003-2006, Wuhan University, B.S in Immunology

2006-2009, Wuhan University, Ph.D in Immunology

2010-2012, Postdoctoral Fellow, Department of pharmacology, University of Minnesota, MN, U.S.A.

Research Description

Study on the structure and function of proteins: focus on the structure of virus proteins and receptors, structures and functions of immune related proteins.

Study on the relationship between innate immunity and tumor or infectious diseases, anti-tumor drug screening.

Publication list

1. Liu C, Yang Y, Chen L, Lin Y-L, Li F. A unified mechanism for aminopeptidase N-based tumor cell motility and tumor-homing therapy. J Biol Chem.2014. 566802.

2. Chen L, Li F. Structural analysis of the evolutionary origins of influenza virus hemagglutinin and other viral lectins Journal of Virology, 2013. 87, 4118-4120.

3. Chen L, Lin Y, Peng G, Li F. Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc Natl Acad Sci U S A. 2012.109(44):17966-71.

4. Peng G, Xu L, Lin Y-L, Chen L, Pasquarella J, Holmes K, Li F.. Crystal structure of bovine coronavirus spike protein lectin domain. J Biol Chem. 2012 .287: 41931-41938.

5. Li L, Wang L, Xiao R, Zhu G, Li Y, Liu C, Yang R, Tang Z, Li J, Huang W, Chen L, Zheng X, He Y, Tan J. The invasion of tobacco mosaic virus RNA induces endoplasmic reticulum stress-related autophagy in HeLa cells. Biosci Rep. 2012 Apr 1;32(2):171-86.

6. Wu K, Chen L, Peng G, Zhou W, Pennell CA, Mansky LM, Geraghty RJ, Li F. A virus-binding hot spot on human angiotensin-converting enzyme 2 is critical for binding of two different coronaviruses. J Virol. 2011 Jun;85(11):5331-7.