Ruijing Xiao, PH.D

E-mail Address: xrj7619@aliyun.com

Office Address: 185# DongHu Road, Wuhan, Hubei, 430071

Position(s): Lecture

Affiliation(s): Department of Immunology

Research interests / Specialties: Tumor Immunity, hematogenic immunity

Education and Training

1994-1999, B.M. Wuhan University School of Medicine, Wuhan,

People’s Republic of China.

2005-2010, Ph.D. Wuhan University School of Medicine, Wuhan,

People’s Republic of China.

2008-2009, Joint training Ph.D. Université Henri Poincaré-Nancy 1, France.

Research Description

We are interested in chemokine and chemotactic cytokine receptors and the correlation of leukemia drug resistance. Our results demonstrated that the drug resistance of MOLT4 cells induced by CCL25 up-regulated the drug efflux function through affecting interactions between P-gp and ERM and F-actin, in which ERM is the key molecules of CCR9-mediated drug resistance in T-ALL cells. Our study may provide a new way to find a new resistance reversal agent for overcoming chemokine mediated MDR in chemotherapy of leukemia.

Publication list

[1] Li Zhang, Ruijing Xiao, Jie Xiong, Jun Leng, Altaf Ehtisham, Yi Hu, Qianshan Ding, Hui Xu, Shengwu Liu, Jin Wang, Dean G. Tang and Qiuping Zhang*. Activated ERM protein plays a critical role in drug resistance of MOLT4 cells induced by CCL25. Plos One. 2013, 8:e52384. (co-first author).

[2] Xiao R, Wu M, Zheng X, Peng S, Wang M, Zheng Y, He Y, Tan J. Ja33+ MAIT Cells Play a Protective Role in TNBS Induced Intestinal Inflammation. Hepato-Gastroenterology .2012, 59:762-767.

[3] Yuling H, Ruijing X, Li L, Xiang J, Rui Z, Yujuan W, Lijun Z, Chunxian D, Xinti T, Wei X, Lang C, Yanping J, Tao X, Mengjun W, Jie X, Youxin J, Jinquan T. EBV-induced human CD8+ NKT cells suppress tumorigenesis of EBV-associated malignancies. Cancer Research. 2009, 69: 7935-7944. (co-first author).

[4] Xiao W, Wang L, Xiao R, Wu M, Tan J, He Y. Expression profile of human immune-responsive gene 1 and generation and characterization of polyclonal antiserum. 2011. Mol Cell Biochem. 353:177-187. (co-first author)

[5] Yuling H, Ruijing X, Xiang J, Yanping J, Lang C, Li L, Dingping Y, Xinti T, Jingyi L, Zhiqing T, Yongyi B, Bing X, Xinxing W, Youxin J, Fox DA, Lundy SK, Guohua D, Tan Jinquan. CD19+ CD5+ B Cells in Primary IgA Nephropathy. 2008. J Am Soc Nephrol. 19: 2130–2139. (co-first author)