Jie Xiong, PH.D

E-mail Address: jiexiong@whu.edu.cn

Office Address: 185# DongHu Road, Wuhan, Hubei, 430071

Position(s): Lecture

Affiliation(s): Department of Immunology

Research interests / Specialties: Tumor Immunity

Education and Training

1996-2001, B.M. Wuhan University School of Medicine, Wuhan,

People’s Republic of China.

2001-2006, Ph.D. Wuhan University School of Medicine, Wuhan,

People’s Republic of China.

2007-2009, Visiting Researcher. Medical University of Fukushima, Japan.

Research Description

We are interested in a novel gene PEG10, which were highly expressed in a great majority of cancers but absent in normal tissues. Our results demonstrated that PEG10 enhanced the apoptotic resistance and adherence ability of Raji cells. It also could affect the migration and invasion capacity of Raji cells by regulating the expression of MMP-2 and MMP-9. Our data also showed that PEG10 gene closely related with epithelial-mesenchymal transition (EMT) in invasion and metastasis of lung cancer. Our findings suggested that PEG10 play an important role in cancers and drugs inhibiting PEG10 could be a novel approach for the cancer chemotherapy.

Publication list

[1] Deng X, Hu Y, Ding Q, Han R, Guo Q, Qin J, Li J, Xiao R, Tian S, Hu W, Zhang Q, Xiong J (corresponding author). PEG10 plays a crucial role in human lung cancer proliferation, progression, prognosis and metastasis. Oncol Rep. 2014;32(5):2159-67.

[2] Qin J, Liu M, Ding Q, Ji X, Hao Y, Wu X, Xiong J (corresponding author). The direct effect of estrogen on cell viability and apoptosis in human gastric cancer cells. Mol Cell Biochem. 2014;395(1-2):99-107

[3] Han RF, Ji X, Dong XG, Xiao RJ, Liu YP, Xiong J(co-corresponding author), Zhang QP. An epigenetic mechanism underlying doxorubicin induced EMT in the human BGC-823 gastric cancer cell. Asian Pac J Cancer Prev. 2014;15(10):4271-4.

[4] Han R, Xiong J(co-first author), Xiao R, Altaf E, Wang J, Liu Y, Xu H, Ding Q, Zhang Q. Activation of β-catenin signaling is critical for doxorubicin-induced epithelial-mesenchymal transition in BGC-823 gastric cancer cell line. Tumor Biol. 2013;34(1):277-84.

[5] Xiong J(corresponding author), Qin J, Zheng Y, Peng X，Luo Y, Meng X. PEG10 promotes the migration of human lymphoma cells by up-regulating the expression and activity of matrix metalloproteinase-2 and -9. Clin Invest Med. 2012;35(3):E117-25.