Li Zhang, PH.D

E-mail Address: syszhang@whu.edu.cn

Office Address: 185# DongHu Road, Wuhan, Hubei, 430071

Position(s):

Lecturer

Affiliation(s):

Department of Pathology

Research interests / Specialties:

The role of Tyrosine Phosphatase SHP-1 in Allergic and the role of Anaphylactic Inflammation-1 in Anaphylactic Inflammation

Education and Training

B.S., 1998-2003 Wuhan University, China

Ph.D., 2003-2009 Wuhan University, China

Trainee, 2007-2009 Johns Hopkins University School of Medicine, U.S.A

Post-doctoral training, 2013-2014 Yale University School of Medicine, U.S.A

Research Description

I. Characterize the SHP-l-deficient mast cells, including distribution in the lung and the function of these cells with and without stimulation. In addition, mast cells from mev mice with selective deletion of Th2 cvtokine gene will be characterized.

2. Determine whether the mev pulmonary phenotype is mast cell-dependent. Using genetic approaches we will cross breed mev mice to Kw/sh mice and examine changes in pulmonary pathology and cytokine profiles. These.studies will define whether mast cells are necessary for the allergic inflammation seen in mev mice.

3. Determine whether SHP-I deficient mast cells are able to directly induce tissue inflammation. We will use adoptive transfer technique to test this in WT and mast cell deficient mice.

Publication list

1. Li Zhang, Youyou Wang, Min Peng, Qian She, Qunying Xiang, Qing Chen, Zhong Liu,Wei Zhang, Ning Tao, Lixin Qiu, Xinxing Wu. Prevalence and Type Distribution of High-risk Human Papillomavirus Infections among Women in Wufeng County, China. Archives of Gynecology and Obstetrics, 2012; 286 (3):695-699 .

2. Li Zhang, Dangxiao Cheng, Ning Tao, Min Zhao, Fan Zhang, Yulin Yuan, Xiaoping Qiu. Distribution of HLA-A, -B and -DRB1 genes and haplotypes in the Tujia population living in the Wufeng region of Hubei province, China. PLoS One. 2012;7(6):e38774. 2012 Jun 14.

3. Li Zhang, Oh S.Y, Tao Zheng et al. SHP-1 Deficient Mast Cells are Hyperresponsive to Stimulation and Critical in Initiating Allergic Inflammation in the Lung. The Journal of Immunology, 2010 1;184(3):1180-90.

4. Li Zhang, Oh S.Y et al. Role of Protein Tyrosine Phosphatase SHP-1 on Mast Cell Differentiation, Proliferation and Cytokine Production. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009;123( 2) 198-S198