Song Han, PH.D
E-mail Address: hansong@whu.edu.cn
Office Address: 185# DongHu Road, Wuhan, Hubei, 430071
Position(s):
Lecturer
Affiliation(s):
Department of Pathophysiology
Research interests / Specialties:
Potassium channels and autoimmune diseases, pre-clinical research of peptides
Education and Training
B.S., 1999-2003 College of Life Sciences, Wuhan University, China
Ph.D., 2003-2008 College of Life Sciences, Wuhan University, China
Post-doctoral training, 2008-2011 School of Basic Medical Sciences, Wuhan University, China
Research Description
My research focus on design and pre-clinical research of peptide lead compounds for the therapy of autoimmune diseases, which are related to regulation of potassium channels. And I also investigated mechanism of interaction between potassium channels and peptides, and function of potassium channels in neurological autoimmune diseases.
Publication list
1.Feng J, Yu C, Wang M, Li Z, Wu Y, Cao Z, Li W, He X, Han S*: Expression and characterization of a novel scorpine-like peptide Ev37, from the scorpion Euscorpiops validus. Protein Expr Purif 2013, 88(1):127-133.
2.Lu J, Chen X, Zhang Y, Xu J, Zhang L, Li Z, Liu W, Ouyang J, Han S*, He X*: Astragalus polysaccharide induces anti-inflammatory effects dependent on AMPK activity in palmitate-treated RAW264.7 cells. Int J Mol Med 2013, 31(6):1463-1470.
3.Xie S, Feng J, Yu C, Li Z, Wu Y, Cao Z, Li W, He X, Xiang M, Han S*: Identification of a new specific Kv1.3 channel blocker, Ctri9577, from the scorpion Chaerilus tricostatus. Peptides 2012, 36(1):94-99.
4. Han, S*., Youtian, H*., Yi, H., Cao, Z.J, Wu, Y.L and Xiaohua, He. ImKTx88, a novel selective Kv1.3 channel blocker derived from the scorpion Isometrus maculates. Toxicon. 2011, 57(2):348-55.
5. Han, S*, Yin SJ*,Yi H*, Mouhat S, Qiu S, Cao ZJ, Sabatier JM, Wu YL, and Li WX. Protein-protein recognition control by modulating electrostatic interactions. J. Proteome Res. 2010, 9: 3118-3125.
6. Han, S*., Yi, H*., Yin, S.J*., Chen, Z.Y., Liu, H., Cao, Z.J., Wu, Y.L. and Li, W.X. Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease. J. Biol. Chem. 2008, 283: 19058-19065.
